ID U6L8D5_9EIME Unreviewed; 4908 AA.
AC U6L8D5;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE SubName: Full=Dynein heavy chain protein, related {ECO:0000313|EMBL:CDJ46692.1};
GN ORFNames=EBH_0013190 {ECO:0000313|EMBL:CDJ46692.1};
OS Eimeria brunetti.
OC Eukaryota; Sar; Alveolata; Apicomplexa; Conoidasida; Coccidia;
OC Eucoccidiorida; Eimeriorina; Eimeriidae; Eimeria.
OX NCBI_TaxID=51314 {ECO:0000313|EMBL:CDJ46692.1};
RN [1] {ECO:0000313|EMBL:CDJ46692.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Houghton {ECO:0000313|EMBL:CDJ46692.1};
RA Reid A.J., Blake D., Billington K., Browne H., Dunn M., Hung S.,
RA Kawahara F., Miranda-Saavedra D., Mourier T., Nagra H., Otto T.D.,
RA Rawlings N., Sanchez A., Sanders M., Subramaniam C., Tay Y., Dear P.,
RA Doerig C., Gruber A., Parkinson J., Shirley M., Wan K.L., Berriman M.,
RA Tomley F., Pain A.;
RT "Genomic analysis of the causative agents of coccidiosis in chickens.";
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:CDJ46692.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Houghton {ECO:0000313|EMBL:CDJ46692.1};
RA Aslett M.;
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBUNIT: Consists of at least two heavy chains and a number of
CC intermediate and light chains. {ECO:0000256|ARBA:ARBA00011655}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
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DR EMBL; HG710461; CDJ46692.1; -; Genomic_DNA.
DR EnsemblProtists; CDJ46692; CDJ46692; EBH_0013190.
DR VEuPathDB; ToxoDB:EBH_0013190; -.
DR OrthoDB; 275566at2759; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR CDD; cd00009; AAA; 2.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR013594; Dynein_heavy_tail.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR10676:SF314; CYTOPLASMIC DYNEIN 1 HEAVY CHAIN 1; 1.
DR PANTHER; PTHR10676; DYNEIN HEAVY CHAIN FAMILY PROTEIN; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08385; DHC_N1; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SMART; SM00382; AAA; 4.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT DOMAIN 2054..2197
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2348..2438
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2685..2843
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 3064..3230
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT REGION 2922..2941
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 902..948
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3371..3419
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3563..3653
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 4908 AA; 547644 MW; CB1F183E9767E218 CRC64;
MDQTVERAKV SLINFLLEVT PPLLGCSRQQ LQQLLSRQSE SVLKPFLVEQ QPGVLVIGKE
AARESAAAAA KTAAEGGQPA AAAAAAAAAF DADDEEESYN LYVDLGFVAR ASGRCCSVAF
IKRPGFSLAD EAHAAAAAAQ HEEEATERDS EEKLNRAATH IVTKPIGPQL ALMRCGFGEE
ESLLDVTEMY MQRGFGPLLK TAAEEESAAA AAEGAGAEGG AAAAAAADEA AARTSHGMQA
VSKKLRELVL AVQQAQQNVD IPLIELPIDS VIKAAVMKAA AEKRKPVVED LGDKLQDSTY
LIALQSHVNR WIKDIQKVCR MQRDPSTGTA AEEVNFWLGF ERALKHVEEQ LKTPEAEFTL
AVLKHTRRVF ATMSFEQDSG LKQGIEVVQN TNILMRDFPL NDMRTAQTVE QLTQAVRTLF
HHLKKLKNAT LYPLSRAFFL VEALSRDLAA QLLSITARHS LVAMPYEEFE HTAAGCSELF
RTWDEEVRHF RENVRELSKK RGLNERPPSK LVCEHVVLQE RIVEVRQFRR QHHRLKEVLN
RVLGDGSGRD VAAQKDIAAA YQIIEALDVL DVSRAGEEAW EAGQKAYDMR IDRVESQITA
KLRDRLGASK TSAEMFRVFS HFNALFFRPR IRGAIQEYQT KLIQVVKEDL KRLQGIFLEG
FQTTEANTMA EVRDMPRVAG MIVWSKQVER RLDALVQRIQ DVLGKGWEQH VDGQKLKLDI
DHFRAKLNPQ EHFDNWLSLV RDQKRLDTAE RIFNIQDWGA GRLELCVNFD KDMLSLFKEV
RLLSSLQYRV PYSVKVMADE AKVLYPFTMT LQEVLRTYME SCACVGDTIT TSLPAAGAAA
AGTAADADAE AEDSAVALLV ASYQRDCQAK LAEGMNLCWD SDRLETYVKR LAEIVYIFEA
KAEFALQQHQ KAIKEIDTLK DKPVDAPYQD ILAVLQNVQK LIEELQLQNY SNIREWTKVL
ENRVELILTN RLIKLVEEWT SQFEDWPNKG TALIQNGLVL EIQVRNQVLK VHPAVEAARQ
LWMGSLHRVV ASVCLLPRFN SRNSSRSLKF GGDPSAFEYE KSDEEIEENE DPIKPQTKGT
YRIIASKIPD DVMDRAHAAI DRVMEKVEDY VGTWMHYQVL WDVDVSEVLG KLGEDIETWQ
QLLNEIKQAR SPFDAGEARV MFGPTIVDHH QVQAKLNSRY DAWQRGILHA FAQKVSTNAA
GVFTALHAMV VDLEEEGQTA DPTETNMNAA TFLSMSEAQM TAFISSQGLI GDELISNIVS
NLTKFLLKLQ EASKLEPKWN ATIETLRASE RLLERQRYTF PSDWLWTDRI EGEMEVFVQL
LRHQGMLVEQ VRVHLVTLVT QFAAGLQEKL QQLYSDWMLQ RPVRDDIAPG HAMNILKKYE
QQLERITADY ERGEKAKAAL GVEDAAAFSQ GAETFSPSAL AEEIADMKGV WQALGGLHAE
LTALRETLWA AVVPKQIRGT LESLLERIKQ IPARFRQYEA FEEIKQKINK FLSLNLLVTD
MKTDALKERH WKGILSKLKI RKSLADMTIG NLWDADLAGN EADIREVLVQ AQGESALEEF
LRQVKDSWRE REFVTVPCGG KCKVIKGWEE LFQTIDDQLA SIQSMKMSPF FKIFEEEALT
WEEKLNRLRI LLDSWVEVQR KWLYLEGVFS GSQDIQLLLP AEHQRFRSID VEFKGIMKKA
DTTKVVLEVA STEGLARQLE RLSDLLSRIQ RALGEYLEKQ REQFSRFYFV GDEDLLEMIG
NAKDVKLVQR HVSKLFAGIA ALETDPNDPT TITAMVSREG EAVQFVSGVS ILQYASLKDW
MSAVELQMTV TLADAVSRAL RALEQFDFAE LTATATATAA AAAAAEGAAD GAADGAADGA
AAAAGSSSSS SDPLENPFVK WIKEFPLQAL LLAMNIRWTK QCEGALAADE QQQTNAENTN
SNKHPLETSA LQDCINLLGF LADRVVQDVG PLIRNRMVHM ITEVVHQRDV CRALIKNKVG
SKKDFGWLQC MRFYFTHPSP SAPFTPQGLL KVCMADAAFD YGFEYLGMSE RLVQTPLTDK
CFLTLTQALK MKLGGNPFGP AGTGKTESVK ALGSALGRYT LVFNCDETFD FNAMGRLFSG
LCQVGAWGCF DEFNRLDERI LSAVSEQILT IQIGLREGRK EIELLGKATK LNTNVGIFVT
MNPGYAGRSN LPDNLKQLFR EVAMIKPDKQ LIAQVTLYAQ GFRSAERLSS KIISLYDLCD
RQLSKQPHYD FGLRSLKSAL SSAGNLKRQL LQEEAGAGAV VDDPAVVEAV EQKLLIRSVT
DTVVPKLVAQ DVPLLRSLLM GVFPGADIPC LDEKILLDEI ERLCESRFLE AKGEWLEKVL
QLYQIQRLQH GVMLVGPVGT GKSAAWRVLL DAMEKVDGVK GMSYVLVAKE QLYGKLDSTT
LEWQDGVFTA VLRKILATTQ EAGTGAAQRR HWIVFDGDVD PDWAENLNSA LDDNKLLTLP
NGERLEIPSC IRLIFEVETL KYATLATVSR CGIVWFASSV LPDEVVFQHH LDGLAAGSAA
TEVLLQGVGG QAKGIDRSGS GRAISREFGR SGPHIISKAS VNKLASKANL SGGAAGARGA
AEAWMVLSIL WGMGGSLSLA SRQAFSEEVA RICDLPLPPS LSADGGSGET LLDFEPSLED
GQWHSWKSRV KQMEIDTQQV KDASLVIQTV DTLRHRDVVE GWLEEKKPFI LCGPPGSGKT
MTLTAVLKER ADFDVAFLNF SSGTTPDLLF KTFDHYCELT KTAAGGMVMR PLVPGRTLII
FCDECNLPSP DKYGTQHVIM LIRQIAESGG FWRSMPQLQQ ASPWVWIRVE GVQFAGACNP
PTDAGRHHMS NRFLRHAPII FVDFPGKESL VQIYRTFNTA LLRPYPSLFP SADALTMAMV
DFYTSFSSTF TVDQQPHYIY SPRELTRWKL ALAEALEGGT RTDSEAIRKS SSGETNWGRS
EQLRGANDAN EITLTQLVRT YAHEGLRIFS DRLVTEAERE KTDKMLDAIV QTHFPSVCQE
ALQRPILFTS LASRQYCEVS MPALRSLLQG KLRVFNEEVF QVQLVFFDEV LHHVARIDRV
LRQPLGHLLL VGASGAGKTI LTKFVSWMNG LSIFQIKAGR NYNTASFEQD LRVVMKRAAL
KDERIAFVID ESNALGPAFL ERMNALLASG EVPGLFEGDE YTALINECKA AYGSDYLGSG
ESSELFARFT KQVQRNLHII FTMNPANPDF YNRQATSPAL FNRCVIDWFG DWAQPAMEQV
AFEFTDSIEL LPDSFTPEAT VGAKPISSIR REAAADAPEE ETNVDADDLA RRSRLATAIV
SFHHAVAKSN AILAKSGRKS NYMTPRDFLD FLHHFRGLVA EKSDASGEQQ HHLQAGLQTL
AQVERQVGEM RTELTEKGAV LAEKNEEAEK KMQQMINQQA EAEDKKKGAE VLARKLDEQT
GIIKERRAVV EAQLSEVEPL LREAAEAVTN IPKKSLDELK SMANPPAMAK VAVEAVAVLI
TDAGEKTVSW EDARKILKAS DFISKILNFD CASVSSATRR RIQSKFLTGD WDIDRINKAS
RAAGPLAQWV ESSVKFVLIS EQVEPLQTEI AQLETEAQEN EANLQEQQSL ITQLEGKLQQ
YKQDYAQLIS QVQSIKHEME EVQKKCARSM SLLENLGSEK NRWFEQLEQL KLATQTFIGD
SLLAAAFCAY LGFFEYADRH RLLEEWRAVL ERECIRCRVD LSFVDFLSTP SERLQWAAHS
LPPDDLSVQN AIILKRFLRY PLIIDPAGQA INFLTSFLSS NKLSKTSFLD ANFLKALESS
LRFGSTLVIQ DVEKVDPILN PVLNRETHKL GGRVLITVGD SEIDLSPAFS MYLATRDPTA
QFTPDICSRV TIINFTLTPS SLVNQCLNLI LKSERADIDK KRSDMLKLQG EFKVKIRELE
DALLLALSNV KGNILDDDSV MSSMEMLKRQ AAEVAAEAAH TEEIMAEVDQ TSNMYLPWAL
AAGRIYFTLL NLSCVSPVYQ YDLRFFLGIL HDTLTGAAGL SDLKRTDYSE RLSVLLSGLF
STTFKRVAYG LGYYDRLVFA LQLCFIRTEL DLGSPLGLPE LQLLLQGFVE DQTAAAAATA
SWTTTLNGEL TAEQMKALQK LLALPCFSSL QEHMEVHETE WLSMLQSSSP ESNFPPDVFT
GEPHAHAEKK IGSDGTITLG EWIKLLRELL VLRALRPDRV TCVLIELCES VLGKDFLTVP
ELTQDLLREV VEKQASSTSP VLFVLSPGSD PSSLITQLAA AVQQPISSVA MGSKEGFELA
DKAIAKATRH GTWVLCKNVH LSLKWLQDLE TNLHRGQAHT NFRLFLTMEY NPKVPATLVR
ASCTFVFEPP LGIKASLYRS YAMLFGASAT RGTTSRSAAQ AQPVQPPAAA RCRLQFLLAF
LHAIILERRR YAPVGWCKLY EFSEADQKCA LSILDSWLAA AAQRGDCISD HVAPERIPWQ
AIRTLIAQVC YGGRLDNAVD ERVLRSFVDY LFRPEAFESD FLLNMPSFIS GGDESADASS
LHAPAELYKT HEQYLAWVDA LPPRDMPAWI GFNSRAEWLL AARQAQSCIT NWSTLLLRGK
EDDIDFHSIA ESILKKGLKR QKSAAAVDAT EIEESAPKAS WLTLLIPVVQ ACISTLPHKL
PVLQRTEKMV QNPMFRCFER ELAVGARLCN LIRESLGELL LVCKGELKIT NSLRELALQI
SSSKVPPEWS QVYVSSQELT VKEWLEDFRR RLAQLAMVSG EFNTVEEKQE GDPYNENGNE
DVQREAAMQL LSRQRDNGEL TQWRIWLGGL FFPSAYLTAT RQAVAQAKGW SLDDLAVEVL
VGAVEAKDDQ SFIITGLTVE GAAWNAKEAC LDVAETLASN LPPMVMRWYN KTEGGKFRQL
EVNYISTPLF LNRSRKDLVA FVDLPSHTQY PSSLWVQRGT AVLLWSDF
//
