ID U6LHV8_9EIME Unreviewed; 908 AA.
AC U6LHV8;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 28-JUN-2023, entry version 36.
DE SubName: Full=Lankamycin synthase, related {ECO:0000313|EMBL:CDJ48838.1};
GN ORFNames=EBH_0080850 {ECO:0000313|EMBL:CDJ48838.1};
OS Eimeria brunetti.
OC Eukaryota; Sar; Alveolata; Apicomplexa; Conoidasida; Coccidia;
OC Eucoccidiorida; Eimeriorina; Eimeriidae; Eimeria.
OX NCBI_TaxID=51314 {ECO:0000313|EMBL:CDJ48838.1};
RN [1] {ECO:0000313|EMBL:CDJ48838.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Houghton {ECO:0000313|EMBL:CDJ48838.1};
RA Reid A.J., Blake D., Billington K., Browne H., Dunn M., Hung S.,
RA Kawahara F., Miranda-Saavedra D., Mourier T., Nagra H., Otto T.D.,
RA Rawlings N., Sanchez A., Sanders M., Subramaniam C., Tay Y., Dear P.,
RA Doerig C., Gruber A., Parkinson J., Shirley M., Wan K.L., Berriman M.,
RA Tomley F., Pain A.;
RT "Genomic analysis of the causative agents of coccidiosis in chickens.";
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:CDJ48838.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Houghton {ECO:0000313|EMBL:CDJ48838.1};
RA Aslett M.;
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP
CC synthases family. {ECO:0000256|RuleBase:RU003694}.
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DR EMBL; HG711335; CDJ48838.1; -; Genomic_DNA.
DR AlphaFoldDB; U6LHV8; -.
DR EnsemblProtists; CDJ48838; CDJ48838; EBH_0080850.
DR VEuPathDB; ToxoDB:EBH_0080850; -.
DR OrthoDB; 216608at2759; -.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR Gene3D; 3.40.47.10; -; 2.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF37; FATTY ACID SYNTHASE; 1.
DR Pfam; PF00109; ketoacyl-synt; 2.
DR Pfam; PF02801; Ketoacyl-synt_C; 2.
DR SMART; SM00825; PKS_KS; 1.
DR SUPFAM; SSF53901; Thiolase-like; 3.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 1.
PE 3: Inferred from homology;
KW Transferase {ECO:0000256|RuleBase:RU003694}.
FT DOMAIN 1..532
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT REGION 1..30
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 108..167
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 224..244
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 399..418
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 8..30
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 108..130
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 139..167
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 908 AA; 95270 MW; 546646C1F404ADA7 CRC64;
MAGLRPRRQY LQQQQQQQQQ QGLQQQQHST VEEIGRDTAV FIGCSSVDWR SLLEVSAGGP
FSLASSSPSF LSSRVSREFE FIGPSLVLDA ACASGLAALH LAQQHLTSST SSSSSSSSSS
SSSSSSRCGG GGGGGGSGRW SSRRSSNSSS SRSSNSSSSS SSSSSSRWAI VGGSNLVLDA
AAARAFAAAG LLSPSGRCCS FDARADGCLR GEAVVVLLLE RMDSSSSSSS SSSSSSSCSS
SSSSSREEHV LGYLRGSSLQ QASRTRSITA PSCLSQQQLL QQTLDAAGVA AADICLLEAH
ATGTLLGDAV EAAAIAAVFA AEQQLQPCPN CCRIERLQQK QLRQLQQQQQ QQQQQYMRTS
ISRTAAAEAA EQAAAAAAAK AAAGSSRPTN DDWEDMVVTT HHGSSSSSSS SSSSSSSSRM
QRCCCRRLVV GCLKPSLGHS EAASGLCSVL LLLLSLQHRM APPNLLLQRL QQQVQQQWNG
SRILLPSKPY PLNPKEWGSN PSSSKPSHTP QLFAAAAALG LGGSMAYAVV SSSSSRKLLQ
QQHQTSIAWR RNRFPLLPNI QQQQQQQQQQ QHALQQLLQP TLTQLFWGPP DGPMPAPAPA
AAAATAAATA AAAAAGPAAA AAAAAAAGEM QIEGPLLLLC CQEDEAKWRQ SLYASAVRVA
AVGPHTSKQD IVRILQQQQQ QQQQQQQQGH CGSSKSQQQK LMLGWGCVVL GAFAASPLYM
TENLQLPQQQ LLQQQQQQQQ QQQQTHSLRR LLHGYSLLLM LLQALETLGE QQKQLPPVLL
LLQQPPKDSS SSSSSNSNSS SSCCSNSCCG STSTTCCCEA AGLASEGLLQ LLVDAAASFS
SSSRRCTRIS VAVYEQQQQQ QQQALSEEQL QQLHAAAAAA GWPPAAAAAA AAAAAGGPRN
RTEAAAGV
//
