ID U6MCL4_EIMMA Unreviewed; 1483 AA.
AC U6MCL4;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 24-JAN-2024, entry version 40.
DE RecName: Full=Dynein heavy chain family protein {ECO:0008006|Google:ProtNLM};
DE Flags: Fragment;
GN ORFNames=EMWEY_00047000 {ECO:0000313|EMBL:CDJ61972.1};
OS Eimeria maxima (Coccidian parasite).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Conoidasida; Coccidia;
OC Eucoccidiorida; Eimeriorina; Eimeriidae; Eimeria.
OX NCBI_TaxID=5804 {ECO:0000313|EMBL:CDJ61972.1};
RN [1] {ECO:0000313|EMBL:CDJ61972.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Weybridge {ECO:0000313|EMBL:CDJ61972.1};
RA Reid A.J., Blake D., Billington K., Browne H., Dunn M., Hung S.,
RA Kawahara F., Miranda-Saavedra D., Mourier T., Nagra H., Otto T.D.,
RA Rawlings N., Sanchez A., Sanders M., Subramaniam C., Tay Y., Dear P.,
RA Doerig C., Gruber A., Parkinson J., Shirley M., Wan K.L., Berriman M.,
RA Tomley F., Pain A.;
RT "Genomic analysis of the causative agents of coccidiosis in chickens.";
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:CDJ61972.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Weybridge {ECO:0000313|EMBL:CDJ61972.1};
RA Aslett M.;
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; HG722307; CDJ61972.1; -; Genomic_DNA.
DR RefSeq; XP_013338622.1; XM_013483168.1.
DR EnsemblProtists; CDJ61972; CDJ61972; EMWEY_00047000.
DR GeneID; 25338686; -.
DR VEuPathDB; ToxoDB:EMWEY_00047000; -.
DR OMA; CEWARNI; -.
DR OrthoDB; 275566at2759; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45703; DYNEIN HEAVY CHAIN; 1.
DR PANTHER; PTHR45703:SF8; DYNEINS HEAVY CHAIN; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF12777; MT; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 3.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017}; Membrane {ECO:0000256|SAM:Phobius};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1340..1359
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1460..1481
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..152
FT /note="Dynein heavy chain hydrolytic ATP-binding dynein
FT motor region"
FT /evidence="ECO:0000259|Pfam:PF12774"
FT DOMAIN 314..438
FT /note="Dynein heavy chain AAA 5 extension"
FT /evidence="ECO:0000259|Pfam:PF17852"
FT DOMAIN 668..766
FT /note="Dynein heavy chain 3 AAA+ lid"
FT /evidence="ECO:0000259|Pfam:PF17857"
FT DOMAIN 855..1137
FT /note="Dynein heavy chain AAA module D4"
FT /evidence="ECO:0000259|Pfam:PF12780"
FT DOMAIN 1151..1483
FT /note="Dynein heavy chain coiled coil stalk"
FT /evidence="ECO:0000259|Pfam:PF12777"
FT COILED 1136..1236
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1376..1452
FT /evidence="ECO:0000256|SAM:Coils"
FT NON_TER 1483
FT /evidence="ECO:0000313|EMBL:CDJ61972.1"
SQ SEQUENCE 1483 AA; 167615 MW; 8D33CC43660C0671 CRC64;
MLMSEGFVCA RALAHKFVTL YGLCKTLLSD AKHYDWGLRA VKAVLRQAGA LKRADPNVNE
DTLLMRALRD FNIAKITTED KPIFLRLIED LFPGVVSPPK RDVEFWKVVM AVAKAQKLQC
EEQFILKCVQ VREVLQVRHC LFILGPPGAS KSRVWQTLSK ALKAIGEDGV VEVLNPKAIS
TNELYGYMTP AKEWKDGAVA VIMRNMSKER GGFKSSHLHK WIVLDGDIDA EWIESMNTVM
DDNKVLTLVS NERIPFTPTM RMIFEIADMK HASPATVSRG GVVFINETDV GWKPFVDSWR
ETLSDQVAQS QFYLLFSYYF ESNIDMFRRS FKFVCPMTDI AFVDGICCFV DALLCKDKAT
AEAFKSKSVD EQKLTYEGYF LSALMWTVGA CVADDKAVNY RSQFNSWLRA AARIKFPEGG
LCFDYFFEEK TCQWVPWSTQ LMPYEPVTEM LFNKIIVATT DILRINYVNE LFCKRGRAVL
LVGSCGSGKN VCLFFRLALV LMWIKDFLRR LPPEFESATI NLNSYTDSRT LQSILASNIE
KRTGHTYGPV GNKRIVYFID DLNMPFVDKY DTQPPLELLR QLMDYGSMFD RAHLEDRMNV
VDVQYMGCMN PTAGSFNISS RLQRHFSVLT CFEPDAETIE RIYGSILRHH LLPFDAPVAE
LGANIVQASI DLFAQIHADP AFLHSAKKFH YNFNLRDLSN LFQGVLRSSA SLYRQPTGGR
LKLIRLWLHE ANRVLRDRLI CENDMNALDN ILTGVTKKHF PDEEQDQMHA APNVMCSFLS
EASGNDAVRN TIKQRLNQTL FHYCTSTQHS SQAYSIMQTN CTRDVQVYIP AADMDSLRAV
LAEKLEEYSQ TFTEMNLVLF DDAVLHVTRI CRIIDLPGGN ALLVGVGGSG KQSLSRLACF
ISKVDTFQIV VSQHYDCAAF KVDMQELMNK ALVRPGTPHA LLLTDQQIVD EELLVYVNDL
LASGNIPDLF TRDEYEQIFA TLRKQLRPGA AANTREAMWQ VFTDKVQTNV HVILCHSPVG
EHLRVRARKF PGLISGTTID EFHPWSRDAL VQTGTAFLKV LLQHHFILVD AVSAFGTYAI
VANVELPSED LRGLLAEHMA NVHLSIDAAN ERFLREERRH NYTTPKSFLE LIAFYKQFLE
RKREEANQSI ERLQKGLTTL KETTAEVEGL REDLKEKMAV ADEKKAAADA LVEQVLKASA
IADEEAVIAN TEKDKANQLS QEAAAIQQKA DEELSEAMPA MERAREAVKC LTKPAIQELK
SLPKPPAECL EVTKAVLIMR GETKNTEWKA AQKMMSDPAK FLDQVRAFDA ENMTEETVNA
ITPIISQPFF NFEVMKGKSL AAAFLANWVV NIVTYNTIYR KVKPLMDKFA EATESKNKAD
SNLAQVLERV REINEKVAKL QQKMQEADEE RQGVVAQATE CQLKLDLAER LVNGLADENK
RWNESMTELE SSKMTVIGDY LLAAAFVSYA GAFSAPFRVG LIE
//
