ID U6MFI5_EIMMA Unreviewed; 3148 AA.
AC U6MFI5;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE SubName: Full=Phosphatidylinositol 3-and 4-kinase domain-containing protein, putative {ECO:0000313|EMBL:CDJ61214.1};
GN ORFNames=EMWEY_00038880 {ECO:0000313|EMBL:CDJ61214.1};
OS Eimeria maxima (Coccidian parasite).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Conoidasida; Coccidia;
OC Eucoccidiorida; Eimeriorina; Eimeriidae; Eimeria.
OX NCBI_TaxID=5804 {ECO:0000313|EMBL:CDJ61214.1};
RN [1] {ECO:0000313|EMBL:CDJ61214.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Weybridge {ECO:0000313|EMBL:CDJ61214.1};
RA Reid A.J., Blake D., Billington K., Browne H., Dunn M., Hung S.,
RA Kawahara F., Miranda-Saavedra D., Mourier T., Nagra H., Otto T.D.,
RA Rawlings N., Sanchez A., Sanders M., Subramaniam C., Tay Y., Dear P.,
RA Doerig C., Gruber A., Parkinson J., Shirley M., Wan K.L., Berriman M.,
RA Tomley F., Pain A.;
RT "Genomic analysis of the causative agents of coccidiosis in chickens.";
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:CDJ61214.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Weybridge {ECO:0000313|EMBL:CDJ61214.1};
RA Aslett M.;
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; HG722030; CDJ61214.1; -; Genomic_DNA.
DR RefSeq; XP_013337864.1; XM_013482410.1.
DR EnsemblProtists; CDJ61214; CDJ61214; EMWEY_00038880.
DR GeneID; 25337874; -.
DR VEuPathDB; ToxoDB:EMWEY_00038880; -.
DR OMA; EWLPASC; -.
DR OrthoDB; 203296at2759; -.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0044877; F:protein-containing complex binding; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 1.20.120.150; FKBP12-rapamycin binding domain; 1.
DR InterPro; IPR009076; FRB_dom.
DR InterPro; IPR036738; FRB_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR PANTHER; PTHR13491; ZCCHC10 PROTEIN; 1.
DR PANTHER; PTHR13491:SF0; ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 10; 1.
DR Pfam; PF08771; FRB_dom; 1.
DR SMART; SM01345; Rapamycin_bind; 1.
DR SUPFAM; SSF47212; FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP); 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 4: Predicted;
KW Kinase {ECO:0000313|EMBL:CDJ61214.1};
KW Transferase {ECO:0000313|EMBL:CDJ61214.1}.
FT DOMAIN 2971..3148
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT REGION 171..240
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 353..373
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 530..587
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 628..691
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1254..1276
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1383..1470
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1483..1506
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1753..1777
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1790..1831
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2197..2216
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2680..2711
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2728..2750
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3076..3113
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 171..233
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 354..369
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 539..587
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 628..667
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 668..691
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1383..1420
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1431..1452
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1453..1468
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1483..1504
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1790..1806
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2680..2698
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3076..3106
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3148 AA; 333688 MW; FB713BC8D4D2EE74 CRC64;
MKHKQRCVCG AECLGIEGSF PAAAAAASAL CSSSSSNNSS SNSSSSSSNK GGDWLLLPRG
HLRRLRSSCA YKCYEAAATA AELLQQQQQQ QLLPAGAAAA PLLLEVCAAA AEVILHCNRR
RGLHHNKVAA TQLLISAAAA AVQGAGPLAA RPLLQLLPYC LCNSTAAQQR QQQQRQQQQQ
NPAFAAAAGS GSQRSSRRNS SSKVCSLELE RSGDISSSSS SNSSSNSSTR PGSASSDEEE
EGSCCRRCVP LTCSDYYLLE TAADTLAAAS GAATSAAEGC TPVDVAEAAA AASAAAAVEG
PLGLLLLQRI PLEQQQEQQQ QEQQQNALQV ELLSPTAAVR RKEAAAAAAV RLWQPEQQEQ
QQQGEHQQHQ QHRSLWEAMR SLVLPLARPT CAASTAAAAA AAKTAAEAAA TAHLVQQEAA
FILAVAALRN GQQELRDGLL AQDVLLRGAL QDIATLRRRR QQQQQHGREE KQGHALDMQL
RVVLAALQLL TAAAAAETAL TAAPDRSAFG EGGWAAVGIH ELLLPLLHHH HTQQHERQPE
VPEQQQQQQQ HQQLQQPAHR QESQPETPEQ QQQRQQQQQQ QQQQQREASA AREAALWAGC
FILSLDSLPL PLAAALQHGV LHELQHRLHH HHHHHHQHQH QHQQQHQQHH HHHHQHQHQH
QQYQQHQQHH RAVKTASSPC IRCGNSSSSS SSNPFCTSGA GLTLHCVLLL LQQPDEQLQQ
KAERLLPVSL GYLLHNEPLL LLRGMPLQQV LLQTLQGRHA QHLVLQQLLR LLPQCNAAAA
AATLVDIIAA AAHASLCSTG LQQHSSEEEA ICLVVDVLRE LLQQRAPLEL LQCAGAAALA
AAADRCGYVR LAAAETAAAA AAAMAQRPHA AAAETAAAED ICSTAESLLA EGEPLLQRLA
AAALARYLCS STQMAVALLQ SAACPLAAAQ HVLQLRLLLA GAKIGPWEAA ATHAAYCSCM
KITRLLSDVP SCCTNTVAAA AADSPAAAES ACSLATNAAA AAAADSTKET SGANSTAPTG
EATGSSGCCC CSLCALPQEQ QLLQQLQQRK HQRRGLHMLQ QRWRICGSVA VLWGALANIC
MFKQQRQQQQ QQELQHRRQQ LYQQQQWQQQ QQVGAVLLNV LQPASVVIVE SDARIRAAAA
AAVLQLFRCW RDTAAAAEAG AAAAADAESL EAYLGALVHG ATPPPAAAAA QQQLLLLKRG
ISESSPFPII PPAALPDELG YLCQLAAQLK ESVESEWLPA SCAEIAARSW ARCSSSSNSS
SSSSNGSSNN SDSSSSRCRV RSLSATVESA TAWLRCLCCL HQQRCCLLLL PASFGPIASL
LEELRHQKDT PLYVQRMQML QVLDVLLWEV QYEQQQVQHG GAARLCDVIL LLLDSATAEM
SKSLQQQQQQ HKQQQHQTQQ VLPSLTVQQP QQQQQSPEVP QDYPLCCATL PPQQSHIQRQ
QQQQQQQQHQ RHPGGHGAED KPFEQPKMRR QKQQLLQLLP DRHMSLSSSS SSSSSGSGKL
SRSSRMADLS GAAGSAAAAG SAAAAAGLPP VCTAKRDTER AFQARPAAAA AGAAAAAAVL
ACYTGGVDLG CREGNQECMV LLPTTPQQEA FLLLDLLLKL QLHADSNALL PRLTRLLLLH
KKAHEIVNSL DPCSSSSTGD CSSSCCCFTC TSKAMLTGYC SVCEHSISLI RSCCSQRVWS
GMLPLLLVLL HCTPVASSNS SNVSNNWCTG VLGLVRAISV VAGGCGPGPA KQRAAAAVAV
ACAAAHHQQQ QQQQQQQQQQ QSSWRHGRRT EQQVQEAAIL QSASSALSSA QQALQHQLQQ
HQQHHLHQHQ QQSEFGGRRT GGLHCSRVGS GNGGVRRSLG DVFSSFANSS STGTVASSGA
PTGATATAAP AAAAPPAAAT TTTPAAAAVA AWRHSHRRQL RSAPASLRET RGLRLKLWDA
AQGGRVDCWE DWWQRLHGLY VHRSNLACIA AVAPLAKADS DDAAGAAAAP SGGTAAEEKG
AAAAAAAVVA DKLFAVALCE DCFALRAEQN LEAVAAINNG FARCLQESPV SVCRRAVSLG
VYMQQRQQMQ HQMPLQAKHV LLEQQFRQLE RLAKEVMFAV VVDSSQPPAS SSSYAAAAAT
ATEAAVAAQG AAAAAPPPAT PAAVAEAHAQ IAQSMWRCFA FYDSFHPMRK AAGAATAAAA
APALRRTLQQ MQLLPPSAAT QGPTTAADTL DETAATAAAA ATAASPHHLK PTTGSGMSGH
ASLQALYWMG LWSDALGVAA QQQQQHHEAA ATSEALTAAA AAAAFNCRDY EALQLYSKQL
GEPYARYFYT AAGSSCCHTT ATTAAGATAA QAAVDTAATA AAAVCHGACS SSNGMLQALQ
QLQVEALRAS AAADFTAGRG AAAAGAAAEA GSSNSTGCFT AALHKLPHGA LLLPGALRKV
AAAGSLQMPS TEVYPLLRCT AAAASCSSTE AYSGSLLQLL LPLLHYQQKQ RQQQQQQWDP
WCLLLTAREL HRLGQQQEAL QLLSLATDSS CSTSSTSSSS GSSANLGRLQ LPSVPRPLQQ
LMQLPAHAPQ QQELLLLLRA CRATVPASAA AGLTTAAADT VTATAAAANR LAPQQEEVLQ
AAAAAALQCC CRLTLAKWTD EVQELPLHAT TGYSRSSSSS LSPAATNSLL RFAAAAEAAP
AAVRAAASAD CPAAAAAAAA CCYNWGISIL RAVAPMQPRA SRQKQQRQQQ QQHETVVETA
AAATAMHAED SSQAPLLLEE MPQLPAALRQ WQQQQQQQQQ QPSGSKGQGL HLSAGVQQQL
VLEALKSLLR AARLTATTAA ADTAAGIEFA LALLHAIGLA GSEDPRVEQL VSAEMPSLLR
LQQPLLHQLL AKTAAAETKH QERLYTQILI QFGSPSLVRA ATAAAAAAAA SHGSLLQEAR
CLQQQLMQVS VHLGERWFAA LDTASHLAFD KKQHAAAVRL LLPLHEDTLK GPKCAADAAF
LQQHGAALQQ AYMGLQSFIS QGQPGVRIHR VLPRVLVLPT KERPRVITME GRNGCCYRFL
LKAQIDLRLQ QRILLVFKYI SRLLQQQTLQ LPCCCPAAAS APTLKDLLGK YRRMQRVPLN
LELSLFTAEK QQQLHMLQQQ HQQQQQQQQH LHGGHSSSSN ASAAQRAAAS AAKDAPEVVG
SAADVLFSRT SSTLCSSSGS SSLCSSSS
//
