ID   U6MPJ7_9EIME            Unreviewed;       929 AA.
AC   U6MPJ7;
DT   22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT   22-JAN-2014, sequence version 1.
DT   27-MAR-2024, entry version 31.
DE   SubName: Full=3',5'--cyclic-nucleotide phosphodiesterase, putative {ECO:0000313|EMBL:CDJ64414.1};
GN   ORFNames=ENH_00069040 {ECO:0000313|EMBL:CDJ64414.1};
OS   Eimeria necatrix.
OC   Eukaryota; Sar; Alveolata; Apicomplexa; Conoidasida; Coccidia;
OC   Eucoccidiorida; Eimeriorina; Eimeriidae; Eimeria.
OX   NCBI_TaxID=51315 {ECO:0000313|EMBL:CDJ64414.1};
RN   [1] {ECO:0000313|EMBL:CDJ64414.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Houghton {ECO:0000313|EMBL:CDJ64414.1};
RA   Reid A.J., Blake D., Billington K., Browne H., Dunn M., Hung S.,
RA   Kawahara F., Miranda-Saavedra D., Mourier T., Nagra H., Otto T.D.,
RA   Rawlings N., Sanchez A., Sanders M., Subramaniam C., Tay Y., Dear P.,
RA   Doerig C., Gruber A., Parkinson J., Shirley M., Wan K.L., Berriman M.,
RA   Tomley F., Pain A.;
RT   "Genomic analysis of the causative agents of coccidiosis in chickens.";
RL   Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:CDJ64414.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Houghton {ECO:0000313|EMBL:CDJ64414.1};
RA   Aslett M.;
RL   Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; HG722949; CDJ64414.1; -; Genomic_DNA.
DR   RefSeq; XP_013432881.1; XM_013577427.1.
DR   AlphaFoldDB; U6MPJ7; -.
DR   GeneID; 25477037; -.
DR   VEuPathDB; ToxoDB:ENH_00069040; -.
DR   OrthoDB; 5479253at2759; -.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004114; F:3',5'-cyclic-nucleotide phosphodiesterase activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   Gene3D; 1.10.1300.10; 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain; 2.
DR   InterPro; IPR002073; PDEase_catalytic_dom.
DR   InterPro; IPR036971; PDEase_catalytic_dom_sf.
DR   PANTHER; PTHR11347:SF198; CAMP-SPECIFIC 3',5'-CAMP PHOSPHODIESTERASE 4; 1.
DR   PANTHER; PTHR11347; CYCLIC NUCLEOTIDE PHOSPHODIESTERASE; 1.
DR   Pfam; PF00233; PDEase_I; 1.
DR   SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR   PROSITE; PS51845; PDEASE_I_2; 1.
PE   4: Predicted;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        228..253
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        259..281
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        293..311
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        364..381
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        388..406
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          673..864
FT                   /note="PDEase"
FT                   /evidence="ECO:0000259|PROSITE:PS51845"
FT   REGION          1..22
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          36..116
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        54..112
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   929 AA;  104265 MW;  470E826DD3F2A9B9 CRC64;
     MEAPRANEPT SIRSSYLDSR SIANCEVVEL SAGNADYEDA EMPAGRPSAV VLELTHSASP
     TESNDPENYR TPSQHNSTSN RRNGSQLSSP EQTQKKATEG GRQTTSRRES GTSLPKKPLY
     MRLPCIESIA NWFDQMWYAE SVYVRYGEGA ITNVSTKGTA RTKVDMGRSA ATQCSFYSTG
     AGSEAGEISE LKRQQRANIS LLPLRFKDEE TENEFVYNSR RLMEWRSICL FCFKILATTC
     VYAILACGAF GHWTSVPESF ILGLHGIYAT LIFLATCSVL APAIPWIRQR LEYWLYAVLA
     AEAAAVVIFV TNEKLSIYPS HELDPSSMQL SARSLSEEPA GQGICTRNVN LAVFILSMEL
     ILDAWLQFFM YLFMVSVSVV LPTRVRIAAW VQLAVLLLYC LPVFIGQRYC HALLYPELLR
     MLHGLIMLIS SIAGSYASES KRRGLFYSWI MMKRRMKLLE AERDKPRDDN MRSGVSALQR
     HCKQAEVALM SAKTAPGGTN ISSQIRDAVN NIKACLDIMS KSKDLYHTEL KEELREKTFI
     KAFNVEKQTG KGLLAAVDRR VSGAQSVRAG DSVAGQRMNS LPVCTAGVLL PLFTTEIASR
     VGVDITFNQL GFNRKVKEKD ANSSAFFECG YSLLWHYAAD WGCEDCVLRT FLIEIESLYN
     DLPYHNSIHG AMAILYNDRS VLENFHAALT FKVLSHTSCN IFASLAKDEI LEVRSNMISL
     ILATDMKSHF GAINRLRAAR QNPHFDHRKQ RDDTWLIMEM CMRAADIGHS ILSWDQHFEW
     SSRVTAEFYL QGDEEARHGR SISPLCDRDL HSSMARNQVG FLEHLVKPLF VELHSVDSMK
     GAFQEAVDTI DANISRWQQL QDIGVDVTFS PVVMACEDRL KGKDHVLDVS LITETRCRCP
     CCESGNAACK NVGRKVRINE HVEQEKHDA
//