ID U6Q3A1_9CLOT Unreviewed; 1528 AA.
AC U6Q3A1;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 24-JAN-2024, entry version 46.
DE RecName: Full=Calcineurin-like phosphoesterase domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=CSBG_03525 {ECO:0000313|EMBL:EJZ50444.1};
OS Clostridium sp. 7_2_43FAA.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=457396 {ECO:0000313|EMBL:EJZ50444.1, ECO:0000313|Proteomes:UP000017809};
RN [1] {ECO:0000313|EMBL:EJZ50444.1, ECO:0000313|Proteomes:UP000017809}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=7_2_43FAA {ECO:0000313|EMBL:EJZ50444.1,
RC ECO:0000313|Proteomes:UP000017809};
RG The Broad Institute Genome Sequencing Platform;
RA Earl A., Ward D., Feldgarden M., Gevers D., Allen-Vercoe E., Strauss J.,
RA Ambrose C., Young S.K., Zeng Q., Gargeya S., Fitzgerald M., Haas B.,
RA Abouelleil A., Alvarado L., Arachchi H.M., Berlin A., Chapman S.B.,
RA Gearin G., Goldberg J., Griggs A., Gujja S., Hansen M., Heiman D.,
RA Howarth C., Larimer J., Lui A., MacDonald P.J.P., McCowen C.,
RA Montmayeur A., Murphy C., Neiman D., Pearson M., Priest M., Roberts A.,
RA Saif S., Shea T., Sisk P., Stolte C., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Clostridium sp. 7_2_43FAA.";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EJZ50444.1}.
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DR EMBL; ACDK02000034; EJZ50444.1; -; Genomic_DNA.
DR RefSeq; WP_008679963.1; NZ_JH815222.1.
DR STRING; 457396.CSBG_03525; -.
DR GeneID; 65399845; -.
DR eggNOG; COG1409; Bacteria.
DR eggNOG; COG4632; Bacteria.
DR HOGENOM; CLU_002166_0_0_9; -.
DR OrthoDB; 9809781at2; -.
DR Proteomes; UP000017809; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0003993; F:acid phosphatase activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:UniProtKB-KW.
DR Gene3D; 3.60.21.10; -; 1.
DR Gene3D; 2.60.40.380; Purple acid phosphatase-like, N-terminal; 1.
DR InterPro; IPR004843; Calcineurin-like_PHP_ApaH.
DR InterPro; IPR029052; Metallo-depent_PP-like.
DR InterPro; IPR018711; NAGPA.
DR InterPro; IPR039331; PPA-like.
DR InterPro; IPR008963; Purple_acid_Pase-like_N.
DR InterPro; IPR015914; Purple_acid_Pase_N.
DR PANTHER; PTHR22953; ACID PHOSPHATASE RELATED; 1.
DR PANTHER; PTHR22953:SF153; PURPLE ACID PHOSPHATASE; 1.
DR Pfam; PF00149; Metallophos; 1.
DR Pfam; PF09992; NAGPA; 1.
DR Pfam; PF16656; Pur_ac_phosph_N; 1.
DR SUPFAM; SSF56300; Metallo-dependent phosphatases; 1.
DR SUPFAM; SSF49363; Purple acid phosphatase, N-terminal domain; 1.
PE 4: Predicted;
KW Carbohydrate metabolism {ECO:0000256|ARBA:ARBA00023277};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000017809};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1499..1519
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 116..291
FT /note="Phosphodiester glycosidase"
FT /evidence="ECO:0000259|Pfam:PF09992"
FT DOMAIN 994..1097
FT /note="Purple acid phosphatase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16656"
FT DOMAIN 1104..1295
FT /note="Calcineurin-like phosphoesterase"
FT /evidence="ECO:0000259|Pfam:PF00149"
FT REGION 1449..1484
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1528 AA; 168433 MW; C3CD17E7857E5782 CRC64;
MSKKVKMRIA SLLIAISILI NFIPPLNVKA LGDFGISSPI ISKAINNYNF NLAPGVIEKG
YTFEDNTGKR IESFVIEIDT KNKNVSIEAS TPNDESAYGL QPVRKQAEAL LAKGENVVAG
VNADFYNMAT GEPNGVLLKD GVIIKNHPES RKFFGILKDG SAVIGDYNKF NEVKDNVEEA
LGGNAILVKD GQVFETPQTG ADKEPRTAVG IKSNGNVFFI TVDGRQEPYS AGLSMDDLAQ
LMISMGAIQA LNLDGGGSTT HLSRIPGTDN LEVKNRPSDN SERSVANSWM IISKEPITHE
FNSAYIEPNE RSFTPYSDIR FIAKGIDVSG ASASLPKESL EWSISDNSFG EIDSSTGLFS
STGKEGQAKV LLRYKENVVG EANFEIAKPD EIYFYSKEVS LDKNQSKDLG LNTLFNKRNV
KCNEEDIIWE VPEGMGTVDK DGILYSSDKN SSGEIKATLK GTNISASINV TVGQLPIIIE
DFENGLEKWG FSTANRGESG SLELTKYPEE HTRFDVHSLK INYDFTNAQV GTTLGVYAGP
GENIAIQGSP KSIGMWIYAT KEAKGYWLRM NLIAGDGKSK TIDLSNQNPG IDWEGWKYIE
AEIPDTFIGP FSIHPTQAIR LMSLKSGLPG EGPMTKGSIY VDNIRAVYGN KVDDLYAPVI
ESINIADNDY NRNDVNITAR LYDYEDDQYK TGINWDRVRI LVDGIDYTGK EGHFSYDKDG
TVSLSGYKWA DGTHRVEVVA QDNFGNETTK TEYFNIDTNS SKITIDSINN EAVLGGYLDL
ALKSISGNEI KNLKTKINID NGFLVESVDF SNLSKNGIWN YNSDSGELDI YCENESLTNG
ENILANIKVK IPNTAKLDSD VNFEIINSLM EYTLEKEDNF IATSSSRIGK VPVVSAYNIS
IEEILVGKPG VIKVTDVLGN AVKDVNVIME NEDGNKFDLG KTNSKGILSS DKLTNKVQKF
FIYAEKEGLS SIKIKIQSYA PLKDKIPSNI LFGTTEDAKT QKSISWMSNP LTSKDKVVVQ
YIMKSKYNSK GLLRNKINTK EVEGEYTNLT FSGNSDINLN GVVRSNQIKI TGLEPGTTYM
CRVGDGENWS EFMEFTTLED KENMKFIILG DTQSPSEQGL SELDKILNII ENEHSDSDAI
IHLGDFIDDS SLFNQWNFIT SLFGKYNRAN SIDMINVLGN HEYMGDPSAD KAKKIFNTPT
NGIKENIGGV YSVDYNDIHF SVISFTSDKE LLKKELEWLK EDINNSDKKL KILLTHQPPY
YTNPDGGNEL IKEMLPPVAE ELGIDLVFSG HDHAYGRTKR LKNGIEDKSG TIYIVGGTTG
PKHYQAVNDG SFEVYNDENT AIYTTLEFNK GDIRVISKKP DGTIVDDFNL DKKAPEITIN
GVEDNGVYID SKIKIEVSVD EEAEIITTLN GSPYNGEEIA KAGKYEFAVE ATDKSGNKST
KTINFIIKES DESGENGSEN GGSNNENNNG NNENNNGSIN ENNSLGENSK GELVQTGDLY
SSKLIIIISL ALILIGVTLN KKYKKNLI
//
