ID U7PID6_SPOS1 Unreviewed; 607 AA.
AC U7PID6;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 22-FEB-2023, entry version 26.
DE RecName: Full=Solute carrier family 40 member {ECO:0000256|RuleBase:RU365065};
GN ORFNames=HMPREF1624_08241 {ECO:0000313|EMBL:ERS95363.1};
OS Sporothrix schenckii (strain ATCC 58251 / de Perez 2211183) (Rose-picker's
OS disease fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Ophiostomatales; Ophiostomataceae; Sporothrix.
OX NCBI_TaxID=1391915 {ECO:0000313|EMBL:ERS95363.1, ECO:0000313|Proteomes:UP000018087};
RN [1] {ECO:0000313|Proteomes:UP000018087}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 58251 / de Perez 2211183
RC {ECO:0000313|Proteomes:UP000018087};
RX PubMed=24855299; DOI=10.1128/genomea.00446-14;
RA Cuomo C.A., Rodriguez-Del Valle N., Perez-Sanchez L., Abouelleil A.,
RA Goldberg J., Young S., Zeng Q., Birren B.W.;
RT "Genome sequence of the pathogenic fungus Sporothrix schenckii (ATCC
RT 58251).";
RL Genome Announc. 2:E0044614-E0044614(2014).
CC -!- FUNCTION: May be involved in iron transport and iron homeostasis.
CC {ECO:0000256|RuleBase:RU365065}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU365065}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU365065}.
CC -!- SIMILARITY: Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A
CC subfamily. {ECO:0000256|ARBA:ARBA00006279,
CC ECO:0000256|RuleBase:RU365065}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU365065}.
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DR EMBL; KI440854; ERS95363.1; -; Genomic_DNA.
DR AlphaFoldDB; U7PID6; -.
DR STRING; 1391915.U7PID6; -.
DR eggNOG; KOG2601; Eukaryota.
DR HOGENOM; CLU_020370_5_0_1; -.
DR OrthoDB; 38357at2759; -.
DR Proteomes; UP000018087; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005381; F:iron ion transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR InterPro; IPR009716; Ferroportin-1.
DR InterPro; IPR036259; MFS_trans_sf.
DR PANTHER; PTHR11660; SOLUTE CARRIER FAMILY 40 MEMBER; 1.
DR PANTHER; PTHR11660:SF57; SOLUTE CARRIER FAMILY 40 PROTEIN; 1.
DR Pfam; PF06963; FPN1; 2.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
PE 3: Inferred from homology;
KW Ion transport {ECO:0000256|RuleBase:RU365065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU365065};
KW Reference proteome {ECO:0000313|Proteomes:UP000018087};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU365065};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU365065};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU365065}.
FT TRANSMEM 84..102
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365065"
FT TRANSMEM 288..306
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365065"
FT TRANSMEM 312..334
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365065"
FT TRANSMEM 391..413
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365065"
FT TRANSMEM 451..473
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365065"
FT TRANSMEM 554..575
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365065"
FT REGION 1..65
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 607 AA; 64035 MW; EE5179A65DDB944D CRC64;
MSASTAGRVP DGLLSGEMSV EEGVEGDVEQ GAEQHAEQHA EQPPHQSAAP EAMEEAPEDP
PVPPPPFPTA LATRLYISHF LSTWNSRVFE FAAVLFLAAV FPDTLLPMSV YAVVRGVAAM
VFAEAVGACI DRVDRLVAVR ASILGQRLAV AVSCGVFWAM LAKATASTAT RGGVNDAAPP
AANLTTASST TANALLLPGS LLDAFFSALT GTSATSSVSS TAGTAPTPTA TPSTPVASGL
FAVAVIAACV EKLGSILNLV AVERDWVVVL TEGNAPARRR VSARMRRIDL FCKLVGPLTI
SLVAAASTRA ALWATLGMST ASLVAEYFCI AVVYRRVPAL RRRPAAWDDS AVAPRTTTTT
FWHATKAVAR RLLPFASLPL YVRHPAFLPS FALALLYLTV LSFSGQMVTF LLATGYTPLS
VGLARTASTV CELSATWIAP RLMGRLGVVR GGIWSLSWQA LWLTAGTAVF WGLPSAASPD
GRVGGTAGAT ALAVGVALSR IGLWGYDLCA QSLVQDEVAD AHRGAFSTAE AAFQNLFEVL
AYATTILWAR PDQFRWPVVV SAAAVYTAAA LYTAFVRRRR GHLFHSPLPP AQRWLDKAFS
GRRGVDV
//
