ID   U7PKB8_SPOS1            Unreviewed;       728 AA.
AC   U7PKB8;
DT   22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT   22-JAN-2014, sequence version 1.
DT   27-MAR-2024, entry version 40.
DE   RecName: Full=Carboxylesterase type B domain-containing protein {ECO:0000259|Pfam:PF00135};
GN   ORFNames=HMPREF1624_07624 {ECO:0000313|EMBL:ERS96088.1};
OS   Sporothrix schenckii (strain ATCC 58251 / de Perez 2211183) (Rose-picker's
OS   disease fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Ophiostomatales; Ophiostomataceae; Sporothrix.
OX   NCBI_TaxID=1391915 {ECO:0000313|EMBL:ERS96088.1, ECO:0000313|Proteomes:UP000018087};
RN   [1] {ECO:0000313|Proteomes:UP000018087}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 58251 / de Perez 2211183
RC   {ECO:0000313|Proteomes:UP000018087};
RX   PubMed=24855299; DOI=10.1128/genomea.00446-14;
RA   Cuomo C.A., Rodriguez-Del Valle N., Perez-Sanchez L., Abouelleil A.,
RA   Goldberg J., Young S., Zeng Q., Birren B.W.;
RT   "Genome sequence of the pathogenic fungus Sporothrix schenckii (ATCC
RT   58251).";
RL   Genome Announc. 2:E0044614-E0044614(2014).
CC   -!- SIMILARITY: Belongs to the type-B carboxylesterase/lipase family.
CC       {ECO:0000256|ARBA:ARBA00005964}.
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DR   EMBL; KI440851; ERS96088.1; -; Genomic_DNA.
DR   AlphaFoldDB; U7PKB8; -.
DR   STRING; 1391915.U7PKB8; -.
DR   ESTHER; spos1-u7pkb8; Fungal_carboxylesterase_lipase.
DR   eggNOG; KOG4389; Eukaryota.
DR   HOGENOM; CLU_006586_8_1_1; -.
DR   OrthoDB; 1433837at2759; -.
DR   Proteomes; UP000018087; Unassembled WGS sequence.
DR   Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR002018; CarbesteraseB.
DR   InterPro; IPR019826; Carboxylesterase_B_AS.
DR   PANTHER; PTHR43142; CARBOXYLIC ESTER HYDROLASE; 1.
DR   PANTHER; PTHR43142:SF3; PUTATIVE (AFU_ORTHOLOGUE AFUA_3G09070)-RELATED; 1.
DR   Pfam; PF00135; COesterase; 1.
DR   SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR   PROSITE; PS00122; CARBOXYLESTERASE_B_1; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018087};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           24..728
FT                   /note="Carboxylesterase type B domain-containing protein"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5007329611"
FT   DOMAIN          157..688
FT                   /note="Carboxylesterase type B"
FT                   /evidence="ECO:0000259|Pfam:PF00135"
SQ   SEQUENCE   728 AA;  77056 MW;  405B4372537C47CE CRC64;
     MARSSVAGLA PFLLLPLIQP SFGLFTGGGL TILSQNNLDG AANNGSAAIL VHQPSPFSAA
     ATSCTLLGET PVGASNDHLL QNLAYQAYRG AAHDQQYWVA KETADSDSCR SINAAGNVTT
     TDCLTPLPIL CTQSAPVSNS STADTENGAE WRVVQSVNGT LLTGYRDLHV WKFRGVRYAK
     PPARFTYAEK AEFAIRDEPV LAVTAGADCV QPIGEVRSGS SEDCLFANVW TPHLPAMGDE
     TTAEATNGTT NSTTALRPVM LYLYGGGFTS GSGKNPNTDG TNLASRGDVV VVSVNYRVGN
     AGFLAFDDGV HRGNYALSDM VAALEWVRDY ARYFGGDASR VTLFGESAGA QATHILLGSP
     KARGLFHRAI LQSDPQGYPR NGRFAWMQYD TPAASFRGRT TKVLAEAGCR GTNTTTNTTT
     NTTAAIACLA RLSGFALTNL TTNVNGAVVD GVYLTEPWLV VNGTGRHPNL AGNISVMTGV
     NRDEAGVLVD DYPGNATTFA AYLAGPVGTH FGLPASATAQ TAADAAVASA FGVAANATDP
     ARIFNASMAL ATDGEFTCYD LAKAYSAARH RTFRATYAFQ FNRTYQTAGY TKPWCVPPAT
     PARVHGDPDA EYYKCHAGEQ MVVFGTEARA GRPDRDGLDV PFMQLVVDYW AAFARTGDPN
     PPADYLAVRG HAATLQQTRA TGPWTPVDAA APTVRLLQWN GAQVPFGNAD RCKALGIPLD
     TLETYNRA
//