ID U7PM30_SPOS1 Unreviewed; 1043 AA.
AC U7PM30;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=Sterol regulatory element-binding protein cleavage-activating protein {ECO:0000256|ARBA:ARBA00019541};
GN ORFNames=HMPREF1624_07875 {ECO:0000313|EMBL:ERS95799.1};
OS Sporothrix schenckii (strain ATCC 58251 / de Perez 2211183) (Rose-picker's
OS disease fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Ophiostomatales; Ophiostomataceae; Sporothrix.
OX NCBI_TaxID=1391915 {ECO:0000313|EMBL:ERS95799.1, ECO:0000313|Proteomes:UP000018087};
RN [1] {ECO:0000313|Proteomes:UP000018087}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 58251 / de Perez 2211183
RC {ECO:0000313|Proteomes:UP000018087};
RX PubMed=24855299; DOI=10.1128/genomea.00446-14;
RA Cuomo C.A., Rodriguez-Del Valle N., Perez-Sanchez L., Abouelleil A.,
RA Goldberg J., Young S., Zeng Q., Birren B.W.;
RT "Genome sequence of the pathogenic fungus Sporothrix schenckii (ATCC
RT 58251).";
RL Genome Announc. 2:E0044614-E0044614(2014).
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC {ECO:0000256|ARBA:ARBA00004653}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004653}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the WD repeat SCAP family.
CC {ECO:0000256|ARBA:ARBA00007410}.
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DR EMBL; KI440852; ERS95799.1; -; Genomic_DNA.
DR AlphaFoldDB; U7PM30; -.
DR STRING; 1391915.U7PM30; -.
DR eggNOG; KOG1933; Eukaryota.
DR HOGENOM; CLU_004183_0_0_1; -.
DR OrthoDB; 1422944at2759; -.
DR Proteomes; UP000018087; Unassembled WGS sequence.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:InterPro.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0032934; F:sterol binding; IEA:InterPro.
DR GO; GO:0032933; P:SREBP signaling pathway; IEA:InterPro.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR030225; SCAP.
DR InterPro; IPR000731; SSD.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR PANTHER; PTHR46378; STEROL REGULATORY ELEMENT-BINDING PROTEIN CLEAVAGE-ACTIVATING PROTEIN; 1.
DR PANTHER; PTHR46378:SF1; STEROL REGULATORY ELEMENT-BINDING PROTEIN CLEAVAGE-ACTIVATING PROTEIN; 1.
DR Pfam; PF12349; Sterol-sensing; 1.
DR SUPFAM; SSF69322; Tricorn protease domain 2; 1.
DR PROSITE; PS50156; SSD; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
PE 3: Inferred from homology;
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000018087};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574}.
FT TRANSMEM 34..57
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 288..306
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 318..344
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 422..443
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 505..523
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 287..445
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
FT REGION 1022..1043
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1043 AA; 115997 MW; EBFC8390DF18F8E6 CRC64;
MLWYFLYPLR GTTSAPGLVP NNPLRHILSR YGVYVARHIA TILLIFVAIA TALIYPIPFL
YAPDFTSGAS GLPHHVWTNA QPVKTGLIAT EPNVFMRSIW VHGSYMKALE RNVLLGALEL
QDEILGPTKG FNPRILTNNV TVRDPLANLS VLERDTLHVV NGLTNQSWFF HSPLLYWSND
HDLIATDPNI LATVNEHKNQ HTSLNVTLRH SVVFSGKRFE DRALVAADAI VITLIHLRDS
PVGRQWERKV AELATHVTDK WDIYPQDARN LSSQLYEFQF LPISIQDSVM LTLAYCLTFV
YVIHNLSKIP AIKSRPGLMV TFVTQIFVSI LSSFTVCAIL QIDLSRIPRA AYPIVIISMS
LENMLRLINA VIATNSEEST SSRIGTAFGE TTHIALASVV EHLVLLWGIS KLVTTGLSDF
CAFLAIAIVF DFFYFSTFFL AVLSVEVRRS ELSDFLEKSS STKRNQRPPG RSIYPDVFVS
PQKSISRKSW MTAVLQGRID VSTRIAGTII LLGFVIIAQW HFFENETISH TLNRMFTYGI
GYGGSKNNLT DWSSASSQLR GLHQARSLTS WLRLQDHETA REVIRVVKPE AHSYIARVYE
PLVLVLKGSD RMQSVTERPF LPAVYDFFRH QSTPFLVVIL VLTAAMRIFL NYLLWDEMAD
NSGDVDAPNE PTLSVKTLDQ GHTLDVALLA ATSDGLVVSV GLDRWIRVWN LPHGGVNYPL
RKRDALSDDP FPVLLAIDND STWLAILSHD NVMLWNLETK EWGPSIAIDL SGQKPEAFFF
MPRQRTDLAC SLVVVRRNGT LTELWVDTGE TLDSAICKTT LLSAVYFQPL HSPTTGPSDS
GCMAIIAVSQ NGCVHRATPT HRGWISEEIK QQTDNEEHAH SVVALPLFSA YLVVRPHSVD
MVDLATSETL HTFVSHFQIK PHSIIDTVPG RSNNGDASAF TRMAATATAT STTNASRDKN
YMTHPMAVDE SELLVTELGP IACVGAGTIA LGLGAAIKII TMGHERFGSP AEMLEEAAGQ
MMETSSVANR RRKNRSNQRA MVT
//
