ID   U7PP18_SPOS1            Unreviewed;       685 AA.
AC   U7PP18;
DT   22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT   22-JAN-2014, sequence version 1.
DT   27-MAR-2024, entry version 34.
DE   RecName: Full=Bromo domain-containing protein {ECO:0000259|PROSITE:PS50014};
GN   ORFNames=HMPREF1624_06890 {ECO:0000313|EMBL:ERS96681.1};
OS   Sporothrix schenckii (strain ATCC 58251 / de Perez 2211183) (Rose-picker's
OS   disease fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Ophiostomatales; Ophiostomataceae; Sporothrix.
OX   NCBI_TaxID=1391915 {ECO:0000313|EMBL:ERS96681.1, ECO:0000313|Proteomes:UP000018087};
RN   [1] {ECO:0000313|Proteomes:UP000018087}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 58251 / de Perez 2211183
RC   {ECO:0000313|Proteomes:UP000018087};
RX   PubMed=24855299; DOI=10.1128/genomea.00446-14;
RA   Cuomo C.A., Rodriguez-Del Valle N., Perez-Sanchez L., Abouelleil A.,
RA   Goldberg J., Young S., Zeng Q., Birren B.W.;
RT   "Genome sequence of the pathogenic fungus Sporothrix schenckii (ATCC
RT   58251).";
RL   Genome Announc. 2:E0044614-E0044614(2014).
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; KI440849; ERS96681.1; -; Genomic_DNA.
DR   AlphaFoldDB; U7PP18; -.
DR   STRING; 1391915.U7PP18; -.
DR   eggNOG; KOG1827; Eukaryota.
DR   HOGENOM; CLU_012767_0_0_1; -.
DR   OrthoDB; 2782399at2759; -.
DR   Proteomes; UP000018087; Unassembled WGS sequence.
DR   GO; GO:0016586; C:RSC-type complex; IEA:InterPro.
DR   GO; GO:0006338; P:chromatin remodeling; IEA:InterPro.
DR   GO; GO:0006366; P:transcription by RNA polymerase II; IEA:UniProt.
DR   CDD; cd04369; Bromodomain; 2.
DR   Gene3D; 1.20.920.10; Bromodomain-like; 2.
DR   InterPro; IPR001487; Bromodomain.
DR   InterPro; IPR036427; Bromodomain-like_sf.
DR   InterPro; IPR037382; Rsc/polybromo.
DR   PANTHER; PTHR16062:SF26; -; 1.
DR   PANTHER; PTHR16062; SWI/SNF-RELATED; 1.
DR   Pfam; PF00439; Bromodomain; 2.
DR   SMART; SM00297; BROMO; 2.
DR   SUPFAM; SSF47370; Bromodomain; 2.
DR   PROSITE; PS50014; BROMODOMAIN_2; 2.
PE   4: Predicted;
KW   Bromodomain {ECO:0000256|PROSITE-ProRule:PRU00035};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018087}.
FT   DOMAIN          51..121
FT                   /note="Bromo"
FT                   /evidence="ECO:0000259|PROSITE:PS50014"
FT   DOMAIN          274..356
FT                   /note="Bromo"
FT                   /evidence="ECO:0000259|PROSITE:PS50014"
FT   REGION          1..33
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          145..245
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          375..517
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          603..637
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..28
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        155..206
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        227..245
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        391..433
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        443..501
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   685 AA;  74681 MW;  6EFE81789EDC9386 CRC64;
     MEKRKSTGAD GGDVRASKRL KVVDKPTETA KSTTKTGLEF LDLIRKTSDK NGRRIAEYFE
     TLPPRRGNEA YYKAVRMPIS LQDVEAKLKD GHFKSLSELE SYIKRMVLNV REFYPKGSQQ
     VDDSERVRKA TSNFMVKHNP AYKLNQGYTA VPTPIPDEDE DEDEDEDADG EGDEDAEGDE
     DAEGEDDEGA AEEEAGDNEE EDEDEDNVGT PARRKSSSAK SMRGTPLRVV RKTDRTVTPS
     LKQDHDFDGV PYKGLSFQEA QEKIVEEIIR RPDEEDPSYG YFEPFFNLPP RTLKDYFQVI
     KDPLSIKKLQ KLVKGIRSRT DRSGVTEYKS WAAFEEKASL LWENAYYYNE DGSPIANMAK
     ELEKMFRDEL RQAKEVVQEP PQPKIKIKSA AASTPASSKK ITIHVANTRG SSAESPSGKP
     AGSVSSDAQT GRAAPTPSAL DKTRGLSKAS PSPATSAVAV NGAKRESSSR ASPALSQQPN
     GAVANGSPAL ANGTPAGEST ATNGVAAAPK PPSVPARPVY ETSKFREANR EPLLANLTVQ
     THAALNSGDR RFEIQLPPHP KLAQRSVTLN IPPGQWRQQL FVSLNPTLQS QQRTYKMFVI
     SNGATLGPSP SPSPSPSTAS QGPGSLPGAT PRPDDNAKLY DVNLHPGVNV VQVQVIAGLA
     KGQKLPSGAD AELEKVTIFA NLMKY
//