ID   U7PTE8_SPOS1            Unreviewed;       658 AA.
AC   U7PTE8;
DT   22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT   22-JAN-2014, sequence version 1.
DT   27-MAR-2024, entry version 37.
DE   SubName: Full=CAMKK/CAMKK-META protein kinase {ECO:0000313|EMBL:ERS97755.1};
GN   ORFNames=HMPREF1624_05926 {ECO:0000313|EMBL:ERS97755.1};
OS   Sporothrix schenckii (strain ATCC 58251 / de Perez 2211183) (Rose-picker's
OS   disease fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Ophiostomatales; Ophiostomataceae; Sporothrix.
OX   NCBI_TaxID=1391915 {ECO:0000313|EMBL:ERS97755.1, ECO:0000313|Proteomes:UP000018087};
RN   [1] {ECO:0000313|Proteomes:UP000018087}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 58251 / de Perez 2211183
RC   {ECO:0000313|Proteomes:UP000018087};
RX   PubMed=24855299; DOI=10.1128/genomea.00446-14;
RA   Cuomo C.A., Rodriguez-Del Valle N., Perez-Sanchez L., Abouelleil A.,
RA   Goldberg J., Young S., Zeng Q., Birren B.W.;
RT   "Genome sequence of the pathogenic fungus Sporothrix schenckii (ATCC
RT   58251).";
RL   Genome Announc. 2:E0044614-E0044614(2014).
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DR   EMBL; KI440847; ERS97755.1; -; Genomic_DNA.
DR   AlphaFoldDB; U7PTE8; -.
DR   STRING; 1391915.U7PTE8; -.
DR   eggNOG; KOG0585; Eukaryota.
DR   HOGENOM; CLU_000288_165_1_1; -.
DR   OrthoDB; 5489318at2759; -.
DR   Proteomes; UP000018087; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   CDD; cd14008; STKc_LKB1_CaMKK; 1.
DR   Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR008271; Ser/Thr_kinase_AS.
DR   PANTHER; PTHR24346:SF77; CALCIUM_CALMODULIN-DEPENDENT PROTEIN KINASE KINASE 1; 1.
DR   PANTHER; PTHR24346; MAP/MICROTUBULE AFFINITY-REGULATING KINASE; 1.
DR   Pfam; PF00069; Pkinase; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW   ProRule:PRU10141}; Kinase {ECO:0000313|EMBL:ERS97755.1};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW   ProRule:PRU10141}; Reference proteome {ECO:0000313|Proteomes:UP000018087};
KW   Transferase {ECO:0000313|EMBL:ERS97755.1}.
FT   DOMAIN          119..419
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50011"
FT   REGION          1..92
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          537..599
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..83
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         147
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ   SEQUENCE   658 AA;  71933 MW;  43D990F692EE01B6 CRC64;
     MQQPPTTPPA NASTAHGDIT TSGSRASTGD APSSAHSNDP ASTSSPVTSK PSSPAFPFGQ
     LPTSPGFLSA PTLQSYPSPL RQHRRTPSQH REVKETLNAV SEFADDDEDG SSHHKINQYT
     INFMIGRGSY GSVHVATDQY GKEFAVKEFS KARLRKRARS NLMKQGPFRA GRFPGLGGPV
     GPRGPSSRLE GEAQAEAKDA LYLIREEIAI MKKLNHPNLV ELIEVLDDPE QDSLYMVLEM
     CKKGVIMDVG LGKTAKPYDA EACRCWFRDL ILGIEYLHAQ NIIHRDIKPD NLLITDDDVL
     KIGDFGVSEM FEKADGMRTS KTAGSPAFFP PELCVSNHGG VEGPPCDIWS MGVTLYCLRY
     GKIPFEQETM VDIYEAINTA EVKLPEDEDE QFVDLMGKIL EKDPSKRITM AQLREHPWVT
     LNGDDPLLST EENCANPIEP PNALELNHAF TQNMGNLLCV LKAIRKFKGL LRSRNRDPNL
     AVPPLASDVA ELGSHVSSIR VSSDQERMTE DEVARLVEER RNNIRKASLQ TSRLLGTTAV
     EGQRGGSTSA RDDTDGRENG TGIGVDQPTL LLGIGTGGGD EFGPDRQHDE PEDVVSESPT
     TAEFDVYDRA FQSEVARIQS QGSKSKVYPT KVLESITRGG GGSGMADIVA RLMTEKQQ
//