ID   U7PTH4_SPOS1            Unreviewed;       754 AA.
AC   U7PTH4;
DT   22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT   22-JAN-2014, sequence version 1.
DT   24-JAN-2024, entry version 30.
DE   RecName: Full=AP complex subunit beta {ECO:0000256|PIRNR:PIRNR002291};
GN   ORFNames=HMPREF1624_04069 {ECO:0000313|EMBL:ERS98877.1};
OS   Sporothrix schenckii (strain ATCC 58251 / de Perez 2211183) (Rose-picker's
OS   disease fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Ophiostomatales; Ophiostomataceae; Sporothrix.
OX   NCBI_TaxID=1391915 {ECO:0000313|EMBL:ERS98877.1, ECO:0000313|Proteomes:UP000018087};
RN   [1] {ECO:0000313|Proteomes:UP000018087}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 58251 / de Perez 2211183
RC   {ECO:0000313|Proteomes:UP000018087};
RX   PubMed=24855299; DOI=10.1128/genomea.00446-14;
RA   Cuomo C.A., Rodriguez-Del Valle N., Perez-Sanchez L., Abouelleil A.,
RA   Goldberg J., Young S., Zeng Q., Birren B.W.;
RT   "Genome sequence of the pathogenic fungus Sporothrix schenckii (ATCC
RT   58251).";
RL   Genome Announc. 2:E0044614-E0044614(2014).
CC   -!- FUNCTION: Adaptins are components of the adaptor complexes which link
CC       clathrin to receptors in coated vesicles. Clathrin-associated protein
CC       complexes are believed to interact with the cytoplasmic tails of
CC       membrane proteins, leading to their selection and concentration.
CC       {ECO:0000256|PIRNR:PIRNR002291}.
CC   -!- SIMILARITY: Belongs to the adaptor complexes large subunit family.
CC       {ECO:0000256|ARBA:ARBA00006613, ECO:0000256|PIRNR:PIRNR002291}.
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DR   EMBL; KI440845; ERS98877.1; -; Genomic_DNA.
DR   AlphaFoldDB; U7PTH4; -.
DR   STRING; 1391915.U7PTH4; -.
DR   eggNOG; KOG1061; Eukaryota.
DR   HOGENOM; CLU_006320_4_0_1; -.
DR   OrthoDB; 648032at2759; -.
DR   Proteomes; UP000018087; Unassembled WGS sequence.
DR   GO; GO:0030117; C:membrane coat; IEA:InterPro.
DR   GO; GO:0030276; F:clathrin binding; IEA:InterPro.
DR   GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR   GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR   InterPro; IPR026739; AP_beta.
DR   InterPro; IPR016342; AP_complex_bsu_1_2_4.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR002553; Clathrin/coatomer_adapt-like_N.
DR   PANTHER; PTHR11134; ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER; 1.
DR   PANTHER; PTHR11134:SF3; AP COMPLEX SUBUNIT BETA; 1.
DR   Pfam; PF01602; Adaptin_N; 1.
DR   PIRSF; PIRSF002291; AP_complex_beta; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|PIRNR:PIRNR002291};
KW   Protein transport {ECO:0000256|PIRNR:PIRNR002291};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018087};
KW   Transport {ECO:0000256|PIRNR:PIRNR002291}.
FT   DOMAIN          16..532
FT                   /note="Clathrin/coatomer adaptor adaptin-like N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF01602"
FT   REGION          644..754
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        728..746
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   754 AA;  81885 MW;  6F877192AFEEAE73 CRC64;
     MQAVNRIRGA FAVPRKGETF ELRAGLVSQY AFERKEAIQK TIMAMTLGKD VSALFPDVLK
     NIATSDLDQK KLVYLYLMNY AKSHPDLCIL AVNTFVQDSE DPNPLIRALA IRTMGCIRVD
     KMVDYMEEPL RKTLRDESPY VRKTAAICVA KLFDLNPSMC IDNGFLEILQ ELIGDPNPMV
     VANSVQALSE ITETAPETHA LVVTPTTLKK LLMALNECTE WGRVTILSTL ANYPPKDVKE
     SEHICERVAP QFQHVNPSVV LAAVKVVFIH MKTINAELVR QYLKKMAPPL VTLVASAPEV
     QYVALRNIDL LLQAKPDILS KEMRVFFCKY NDPPYVKLQK LEIMVRIAND KNFEQLLAEL
     KEYALEVDMD FVRRAIKAIG QVAIKIENAS EKCVTALVDL MATNVNYVVQ EVVIVIKDIL
     RKYPGYEGVI RSIVEHIDEL DEPNARGSLI WIVGEYAEKI SNADDILTGF VDGFMEEFTQ
     TQLQILTAVV KLFLKKPSAN QSLVQRVLQM ATAENDNPDI RDRAYVYWRL LSGDLDVAKS
     IVLSQKPAIA TTMTSLPPAL LESLLAELST LASVYHKPPE SFVGKGRFGA DEIQRAAIQE
     QRQDAAENPI AASVAAAAAA ANGGHAPPQS NVENLLDIDF DGAAPASAEA GGASTPDRTG
     SPSVASPSAS PPPPSAGPGG IADMMGLFDA PSASASSPAP PPGMNDILGG FGSLDLNGAG
     RATVPPPPGA QLQQQQQQQQ SSGGGGNGDL LGLF
//