ID   U7PUV9_SPOS1            Unreviewed;       444 AA.
AC   U7PUV9;
DT   22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT   22-JAN-2014, sequence version 1.
DT   27-MAR-2024, entry version 29.
DE   RecName: Full=Translation initiation factor eIF2B subunit beta {ECO:0000256|ARBA:ARBA00044122};
DE   AltName: Full=eIF2B GDP-GTP exchange factor subunit beta {ECO:0000256|ARBA:ARBA00044228};
GN   ORFNames=HMPREF1624_05529 {ECO:0000313|EMBL:ERS98741.1};
OS   Sporothrix schenckii (strain ATCC 58251 / de Perez 2211183) (Rose-picker's
OS   disease fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Ophiostomatales; Ophiostomataceae; Sporothrix.
OX   NCBI_TaxID=1391915 {ECO:0000313|EMBL:ERS98741.1, ECO:0000313|Proteomes:UP000018087};
RN   [1] {ECO:0000313|Proteomes:UP000018087}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 58251 / de Perez 2211183
RC   {ECO:0000313|Proteomes:UP000018087};
RX   PubMed=24855299; DOI=10.1128/genomea.00446-14;
RA   Cuomo C.A., Rodriguez-Del Valle N., Perez-Sanchez L., Abouelleil A.,
RA   Goldberg J., Young S., Zeng Q., Birren B.W.;
RT   "Genome sequence of the pathogenic fungus Sporothrix schenckii (ATCC
RT   58251).";
RL   Genome Announc. 2:E0044614-E0044614(2014).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC       {ECO:0000256|ARBA:ARBA00004514}.
CC   -!- SIMILARITY: Belongs to the eIF-2B alpha/beta/delta subunits family.
CC       {ECO:0000256|ARBA:ARBA00007251, ECO:0000256|RuleBase:RU003814}.
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DR   EMBL; KI440846; ERS98741.1; -; Genomic_DNA.
DR   AlphaFoldDB; U7PUV9; -.
DR   STRING; 1391915.U7PUV9; -.
DR   eggNOG; KOG1465; Eukaryota.
DR   HOGENOM; CLU_016218_4_3_1; -.
DR   OrthoDB; 169494at2759; -.
DR   Proteomes; UP000018087; Unassembled WGS sequence.
DR   GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR   InterPro; IPR000649; IF-2B-related.
DR   InterPro; IPR042529; IF_2B-like_C.
DR   InterPro; IPR037171; NagB/RpiA_transferase-like.
DR   PANTHER; PTHR45859; TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT BETA; 1.
DR   PANTHER; PTHR45859:SF1; TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT BETA; 1.
DR   Pfam; PF01008; IF-2B; 1.
DR   SUPFAM; SSF100950; NagB/RpiA/CoA transferase-like; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000018087}.
FT   REGION          105..136
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          183..211
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        112..136
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   444 AA;  47119 MW;  5BDE3FFEC741F27F CRC64;
     MAPTQHGYAP TLDSFLHAKL HLEAAIEQAC SLLKRRQIRG PESCALVTAH VMSLVVSKAK
     WADVDQLLDR VCQAGRKLVD AQPQELVIGN IVRRVLGLIH DEVEADRTEN GEDPSVTGSM
     SGSISDLRAD SVQPGQVPSI VASPSYTALA RTTRQPSLIV TGPYQSMFNL LSAVEPASVT
     ASGEVSSAGS GASTPVPGGP THGGKGESSR TAALRDEILD GIEEIKDEIG QADDQIAGFA
     ESQIRPGDTV MVYAEPSRTI EKFLIKAAAR RRYTLYLVGA TAPPTSGISS LYKRLGAAKC
     PIVHLSSTAV SAYMSRVNRV VIDARAIAAN GGILAGAGSL RLARAARAQR RTVLVVGGVY
     KLSPEALTNP DAFVEWGEPG QLARFADGSL VGDGGLAIET AVTEFLPASL IDIYVTNLGP
     HTKDYLESVI ADHYKREELE LYKQ
//