ID U7PXJ7_SPOS1 Unreviewed; 1007 AA.
AC U7PXJ7;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=Rad4 beta-hairpin domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=HMPREF1624_03699 {ECO:0000313|EMBL:ERT00328.1};
OS Sporothrix schenckii (strain ATCC 58251 / de Perez 2211183) (Rose-picker's
OS disease fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Ophiostomatales; Ophiostomataceae; Sporothrix.
OX NCBI_TaxID=1391915 {ECO:0000313|EMBL:ERT00328.1, ECO:0000313|Proteomes:UP000018087};
RN [1] {ECO:0000313|Proteomes:UP000018087}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 58251 / de Perez 2211183
RC {ECO:0000313|Proteomes:UP000018087};
RX PubMed=24855299; DOI=10.1128/genomea.00446-14;
RA Cuomo C.A., Rodriguez-Del Valle N., Perez-Sanchez L., Abouelleil A.,
RA Goldberg J., Young S., Zeng Q., Birren B.W.;
RT "Genome sequence of the pathogenic fungus Sporothrix schenckii (ATCC
RT 58251).";
RL Genome Announc. 2:E0044614-E0044614(2014).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the XPC family. {ECO:0000256|ARBA:ARBA00009525}.
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DR EMBL; KI440844; ERT00328.1; -; Genomic_DNA.
DR AlphaFoldDB; U7PXJ7; -.
DR STRING; 1391915.U7PXJ7; -.
DR eggNOG; KOG2179; Eukaryota.
DR HOGENOM; CLU_003639_1_0_1; -.
DR OrthoDB; 181129at2759; -.
DR Proteomes; UP000018087; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:InterPro.
DR Gene3D; 2.20.20.110; Rad4, beta-hairpin domain BHD1; 1.
DR Gene3D; 3.30.70.2460; Rad4, beta-hairpin domain BHD3; 1.
DR Gene3D; 3.90.260.10; Transglutaminase-like; 1.
DR InterPro; IPR018327; BHD_2.
DR InterPro; IPR004583; DNA_repair_Rad4.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR018325; Rad4/PNGase_transGLS-fold.
DR InterPro; IPR018326; Rad4_beta-hairpin_dom1.
DR InterPro; IPR018328; Rad4_beta-hairpin_dom3.
DR InterPro; IPR042488; Rad4_BHD3_sf.
DR InterPro; IPR036985; Transglutaminase-like_sf.
DR PANTHER; PTHR12135:SF3; DNA REPAIR PROTEIN RAD4; 1.
DR PANTHER; PTHR12135; DNA REPAIR PROTEIN XP-C / RAD4; 1.
DR Pfam; PF10403; BHD_1; 1.
DR Pfam; PF10404; BHD_2; 1.
DR Pfam; PF10405; BHD_3; 1.
DR Pfam; PF03835; Rad4; 1.
DR SMART; SM01030; BHD_1; 1.
DR SMART; SM01031; BHD_2; 1.
DR SMART; SM01032; BHD_3; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000018087}.
FT DOMAIN 641..698
FT /note="Rad4 beta-hairpin"
FT /evidence="ECO:0000259|SMART:SM01030"
FT DOMAIN 700..802
FT /note="Rad4 beta-hairpin"
FT /evidence="ECO:0000259|SMART:SM01031"
FT DOMAIN 809..883
FT /note="Rad4 beta-hairpin"
FT /evidence="ECO:0000259|SMART:SM01032"
FT REGION 1..50
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 62..204
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 403..447
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 464..487
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 585..606
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 724..787
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 925..1007
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 85..104
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 119..139
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 150..176
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 180..204
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 433..447
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 589..606
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 724..752
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 753..768
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 930..982
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1007 AA; 110066 MW; F6ADCDEAFF1B7CBD CRC64;
MVARRRSGTA EHRGVTLRAA AAQRQQQRVT AARQRRRDAA AATGDGDMGL PGVYRDMLME
AGVPSPSARR RGVQPTIDLT GESGEPPVKR IKRPGQKSDL PMRGDRSAQK SVADVVVFVD
KDEEEDDEDA ADDVEFEDIV IPEPVIQTRE LDSEDEDDDD DDDNDEEDEE DEESSHQFVF
EDVGSATTTP IKPGSGPPNQ TNATTDTLEL NLTEHESVLT APTRRNGRWG ARAAPASRKK
PLSRAERMHR IEIHKMHLLC LLAHAAQRNR WCNSAKVQKA LRPLLTAKMI SSLNPGGHLS
QFSQTESLKN GLQQVATMFK TRFRITERGM RRALWAESPE QLKDYELPKD AETVLDKDDF
IAAAKSMQGS RDVGAQLFCA LLRAAGVETR LVCSLQPLSF LSNAPTMPKP KSKPSKPTPA
RNDHPIPSIY RSPPSATKAT SGDSENEAMF LSPRRRLGHP DAAAYNVPAV PSTPPKPSTS
APSSSRHVVR GESAFPVYWV EVLDAAHQKW QPVDPLVTCS QWKAAKLEPP AADKNNQLSY
AIGFAAEGDA KDVTRRYAKA YNAKTKRARI DGLIEPAPTI AASKAAASSA GAPPTSSPRT
LSSPTNLSGA KWLRRALRYF CVSALTDVDQ IEDIELNATE SREPMPRNVA DFQNHPVYAL
VRHLRRHEVL VPNATAVGTV AAGAKAPLER IYRRRDVRIA YSADRWYRLG RVVLPNEIPA
KWLPKPRKRG VFDDQGNDDG GVRGHKSQSD GVDDDDNDDD DNDEDDLFGD SAVGGIGQSR
SHPSPLGIPI FTPEQTELYR APPVVDGRIP KNKFGNIELY VPSMVPEGGE HIDDAAAGRA
AYMLGVDYAP ALSGFNFQGR KGTAVLRGAV VATEHAEAVR AVLAGLKDLA VEAVAERRTR
AALRAWTFFL RGLRIRQRIR NAAEDRGELV DGDGQEEEGD DDEVVDHEDE NQGRLDSDED
DAVDDAKSDV TEEFDMVVDD DGDGEFTGGG GGFITDDDYG GGGFIPE
//
