ID   U7Q0N0_SPOS1            Unreviewed;       583 AA.
AC   U7Q0N0;
DT   22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT   22-JAN-2014, sequence version 1.
DT   27-MAR-2024, entry version 38.
DE   RecName: Full=Carboxylic ester hydrolase {ECO:0000256|RuleBase:RU361235};
DE            EC=3.1.1.- {ECO:0000256|RuleBase:RU361235};
GN   ORFNames=HMPREF1624_02629 {ECO:0000313|EMBL:ERT01383.1};
OS   Sporothrix schenckii (strain ATCC 58251 / de Perez 2211183) (Rose-picker's
OS   disease fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Ophiostomatales; Ophiostomataceae; Sporothrix.
OX   NCBI_TaxID=1391915 {ECO:0000313|EMBL:ERT01383.1, ECO:0000313|Proteomes:UP000018087};
RN   [1] {ECO:0000313|Proteomes:UP000018087}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 58251 / de Perez 2211183
RC   {ECO:0000313|Proteomes:UP000018087};
RX   PubMed=24855299; DOI=10.1128/genomea.00446-14;
RA   Cuomo C.A., Rodriguez-Del Valle N., Perez-Sanchez L., Abouelleil A.,
RA   Goldberg J., Young S., Zeng Q., Birren B.W.;
RT   "Genome sequence of the pathogenic fungus Sporothrix schenckii (ATCC
RT   58251).";
RL   Genome Announc. 2:E0044614-E0044614(2014).
CC   -!- SIMILARITY: Belongs to the type-B carboxylesterase/lipase family.
CC       {ECO:0000256|ARBA:ARBA00005964, ECO:0000256|RuleBase:RU361235}.
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DR   EMBL; KI440843; ERT01383.1; -; Genomic_DNA.
DR   AlphaFoldDB; U7Q0N0; -.
DR   STRING; 1391915.U7Q0N0; -.
DR   ESTHER; spos1-u7q0n0; Fungal_carboxylesterase_lipase.
DR   eggNOG; KOG4389; Eukaryota.
DR   HOGENOM; CLU_006586_10_6_1; -.
DR   OrthoDB; 3085104at2759; -.
DR   Proteomes; UP000018087; Unassembled WGS sequence.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR002018; CarbesteraseB.
DR   InterPro; IPR019826; Carboxylesterase_B_AS.
DR   PANTHER; PTHR11559; CARBOXYLESTERASE; 1.
DR   PANTHER; PTHR11559:SF162; CARBOXYLIC ESTER HYDROLASE; 1.
DR   Pfam; PF00135; COesterase; 1.
DR   SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR   PROSITE; PS00122; CARBOXYLESTERASE_B_1; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU361235};
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018087};
KW   Signal {ECO:0000256|RuleBase:RU361235}.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000256|RuleBase:RU361235"
FT   CHAIN           20..583
FT                   /note="Carboxylic ester hydrolase"
FT                   /evidence="ECO:0000256|RuleBase:RU361235"
FT                   /id="PRO_5005147991"
FT   DOMAIN          52..549
FT                   /note="Carboxylesterase type B"
FT                   /evidence="ECO:0000259|Pfam:PF00135"
SQ   SEQUENCE   583 AA;  62076 MW;  CC1A32CACBD6CF92 CRC64;
     MKSVFATAVL AGLAGYAASH PAAAPAAAPV PIPVPVAPPT APLEERGVGV SVTYPEGTVN
     GVSLLNIDSF RGIPFAAPPV GNLRLKPPQR TTKVGTIDGS GIGPSCPQMY MSSGSGDALF
     KLVGDFTNLP LFQTVTGASE DCLTLNVQRP AGTNATSKLP VLFWIYGGGF EFGTNAMYDG
     VSLLGQAAKI NEPFVFVAVN YRMGGFGFLG GKEIKADGAA NLGLLDQRAG LEWVADNIAA
     FGGDPARVTI WGESAGAISC FDHMAMYGGD HTYKGKPLFR GAIMDSGSVI PAEPVDGVKA
     QAIYDQVVKV GGCSGAADTL ACLRGLDYQT FLNAATSVPG IFSYNSLALS YVPRPDGTVL
     TDSPSVLALN GQYADVPFII GDQEDEGTLF AIFPTDVTST DRIVKYLSEY YFFNASQQVV
     QGLVNTYPTD ITAGSPFRTS IFNELYPGFK RLAALLGDMT FTLARRAFLL IDSVNKPATP
     SWSYLASYDY GVPFLGTFHA TDILQTFYGV LPNYASGAIQ TYYINFVTTG DPNKGAPVKM
     QWPQWSAGQK LMNFFPDHAA LLPDNFRQQS FEYLVSNMAS FFI
//