ID   U7Q114_SPOS1            Unreviewed;       762 AA.
AC   U7Q114;
DT   22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT   22-JAN-2014, sequence version 1.
DT   24-JAN-2024, entry version 36.
DE   RecName: Full=Golgi apyrase {ECO:0008006|Google:ProtNLM};
GN   ORFNames=HMPREF1624_02794 {ECO:0000313|EMBL:ERT01543.1};
OS   Sporothrix schenckii (strain ATCC 58251 / de Perez 2211183) (Rose-picker's
OS   disease fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Ophiostomatales; Ophiostomataceae; Sporothrix.
OX   NCBI_TaxID=1391915 {ECO:0000313|EMBL:ERT01543.1, ECO:0000313|Proteomes:UP000018087};
RN   [1] {ECO:0000313|Proteomes:UP000018087}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 58251 / de Perez 2211183
RC   {ECO:0000313|Proteomes:UP000018087};
RX   PubMed=24855299; DOI=10.1128/genomea.00446-14;
RA   Cuomo C.A., Rodriguez-Del Valle N., Perez-Sanchez L., Abouelleil A.,
RA   Goldberg J., Young S., Zeng Q., Birren B.W.;
RT   "Genome sequence of the pathogenic fungus Sporothrix schenckii (ATCC
RT   58251).";
RL   Genome Announc. 2:E0044614-E0044614(2014).
CC   -!- SIMILARITY: Belongs to the GDA1/CD39 NTPase family.
CC       {ECO:0000256|ARBA:ARBA00009283, ECO:0000256|RuleBase:RU003833}.
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DR   EMBL; KI440843; ERT01543.1; -; Genomic_DNA.
DR   AlphaFoldDB; U7Q114; -.
DR   STRING; 1391915.U7Q114; -.
DR   eggNOG; KOG1386; Eukaryota.
DR   HOGENOM; CLU_010246_3_0_1; -.
DR   OrthoDB; 180318at2759; -.
DR   Proteomes; UP000018087; Unassembled WGS sequence.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:UniProt.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0017110; F:nucleoside diphosphate phosphatase activity; IEA:UniProt.
DR   CDD; cd00012; NBD_sugar-kinase_HSP70_actin; 1.
DR   Gene3D; 3.30.420.40; -; 1.
DR   Gene3D; 3.30.420.150; Exopolyphosphatase. Domain 2; 1.
DR   InterPro; IPR000407; GDA1_CD39_NTPase.
DR   PANTHER; PTHR11782; ADENOSINE/GUANOSINE DIPHOSPHATASE; 1.
DR   PANTHER; PTHR11782:SF121; NUCLEOSIDE-DIPHOSPHATASE MIG-23; 1.
DR   Pfam; PF01150; GDA1_CD39; 1.
DR   PROSITE; PS01238; GDA1_CD39_NTPASE; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|PIRSR:PIRSR600407-2};
KW   Hydrolase {ECO:0000256|RuleBase:RU003833};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Nucleotide-binding {ECO:0000256|PIRSR:PIRSR600407-2};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018087};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        551..569
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REGION          592..614
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          725..762
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        600..614
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        144
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR600407-1"
FT   BINDING         181..185
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR600407-2"
SQ   SEQUENCE   762 AA;  82861 MW;  8DA55D57CB3CF95A CRC64;
     MGRKHRWGVI IDAGSSGSRL HVYRWKDPSK AIKDASKEEL HSLPKIKTKW TKKIRPGIST
     FGERPAQVGA DHLQELIDYA LEVVPEDMVA DTPIFLMATA GMRFLPQLQQ TALLRETCSY
     LQQHTKFSLP DCAQNIQVIP GETEGLYGWL AANYLLGGFD HPEEHNHGQN HNTYGFLDMG
     GASAQIAFAP NTTEAAQHAD NLKLIRLRTL DGNPAEHRVF TATWLGFGVN KARESYVKSL
     TDAHQDLITN GVDVPDPCMP KGLRTTLDGT LAGPAGSGIP TLVGTGDFAN CLIETKPLLA
     KDTTCGEGSQ PCLIHDPVPS IDFNINHFVG VSEYYHSTHG FFGEKGDLAY DFSTYQKKVL
     DFCNQDWSKI DAKIEGTSGS DKETRKKKDK DINRTLQDAQ QACFKASWVI NVLHEGIGIP
     RIGLDKLPGL NVSGDAVEES KSSSYLTPFR PVDKIDSVEV SWTLGRILLY ASGQIPPRNV
     RGSGGGSTIG AGKGVAVGFG SNSKDGSIPS DFTYAGSTWE PLKVGSGGSK SDDDWSDKAD
     DIFDKAREKS AIPSAFFFLL IVLLFVFLLR KKERRVRLYN KFGTLIRRSR WPGSPRKPGR
     FSSTIGSGSG STNNGNGALA GLAKMLFRRH SRDYERVLEE GQMDQFELND VDLEDTDLSS
     EGSDGPGSAS SSIRLASAGA ARRSGLATPT LSVDKFDDLR TSAGSNSAMD RSGLVVRTES
     RERLGLGGLG APSLQMLNAG RRSRATSPTR LKSPMMAPLQ ED
//