ID U7Q5K6_SPOS1 Unreviewed; 445 AA.
AC U7Q5K6;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=Mannose-1-phosphate guanyltransferase {ECO:0000256|ARBA:ARBA00018601};
DE AltName: Full=GDP-mannose pyrophosphorylase {ECO:0000256|ARBA:ARBA00031190};
DE AltName: Full=GTP-mannose-1-phosphate guanylyltransferase {ECO:0000256|ARBA:ARBA00030179};
GN ORFNames=HMPREF1624_00740 {ECO:0000313|EMBL:ERT02442.1};
OS Sporothrix schenckii (strain ATCC 58251 / de Perez 2211183) (Rose-picker's
OS disease fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Ophiostomatales; Ophiostomataceae; Sporothrix.
OX NCBI_TaxID=1391915 {ECO:0000313|EMBL:ERT02442.1, ECO:0000313|Proteomes:UP000018087};
RN [1] {ECO:0000313|Proteomes:UP000018087}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 58251 / de Perez 2211183
RC {ECO:0000313|Proteomes:UP000018087};
RX PubMed=24855299; DOI=10.1128/genomea.00446-14;
RA Cuomo C.A., Rodriguez-Del Valle N., Perez-Sanchez L., Abouelleil A.,
RA Goldberg J., Young S., Zeng Q., Birren B.W.;
RT "Genome sequence of the pathogenic fungus Sporothrix schenckii (ATCC
RT 58251).";
RL Genome Announc. 2:E0044614-E0044614(2014).
CC -!- FUNCTION: Involved in cell wall synthesis where it is required for
CC glycosylation. Involved in cell cycle progression through cell-size
CC checkpoint. {ECO:0000256|ARBA:ARBA00024813}.
CC -!- SIMILARITY: Belongs to the transferase hexapeptide repeat family.
CC {ECO:0000256|ARBA:ARBA00007274}.
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DR EMBL; KI440842; ERT02442.1; -; Genomic_DNA.
DR AlphaFoldDB; U7Q5K6; -.
DR STRING; 1391915.U7Q5K6; -.
DR eggNOG; KOG1460; Eukaryota.
DR HOGENOM; CLU_029499_3_0_1; -.
DR OrthoDB; 5486038at2759; -.
DR Proteomes; UP000018087; Unassembled WGS sequence.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0004475; F:mannose-1-phosphate guanylyltransferase (GTP) activity; IEA:UniProtKB-EC.
DR GO; GO:0044271; P:cellular nitrogen compound biosynthetic process; IEA:UniProt.
DR CDD; cd06428; M1P_guanylylT_A_like_N; 1.
DR Gene3D; 2.160.10.10; Hexapeptide repeat proteins; 1.
DR InterPro; IPR001451; Hexapep.
DR InterPro; IPR018357; Hexapep_transf_CS.
DR InterPro; IPR005835; NTP_transferase_dom.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR InterPro; IPR011004; Trimer_LpxA-like_sf.
DR PANTHER; PTHR22572:SF104; MANNOSE-1-PHOSPHATE GUANYLTRANSFERASE ALPHA; 1.
DR PANTHER; PTHR22572; SUGAR-1-PHOSPHATE GUANYL TRANSFERASE; 1.
DR Pfam; PF00132; Hexapep; 1.
DR Pfam; PF00483; NTP_transferase; 1.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
DR SUPFAM; SSF51161; Trimeric LpxA-like enzymes; 1.
DR PROSITE; PS00101; HEXAPEP_TRANSFERASES; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000018087};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 21..214
FT /note="Nucleotidyl transferase"
FT /evidence="ECO:0000259|Pfam:PF00483"
SQ SEQUENCE 445 AA; 49289 MW; 6DBC0B39B15F6775 CRC64;
MATLQLPQRE KSNGVATPTT KAVILVGGSS RGTRFRPLSL DVPKPLFDVA GHPIIWHCVT
AIAKVPSIQE VYLIGYYDES VFRDFIKDAS NEFPKLSIKY LREYQALGTA GGLYHFRDAI
LKGRPERLFV LNSDVCCSFP LGEMLKMFTE KDAEAVILGT RVSEEAASNF GCIVSDSHTR
RVLHYVEKPE SHISNLINCG VYLFSTEAIF PSIRTAIKRR TDRPSRLVSY PSSDNLASSF
IEYDNDNDEQ NNEVIRLEQD ILSDMADSKE FFVYETRDFW RQIKTAGSAV PANALYLQQA
WQTASKELAA PGPNIIQPVF IHPSAHVDPT AKLGPNVSIG PRVTVGAGAR IKESIVLEDS
EIKHDACVLY SIIGWNSRVG AWARVEGSPT PVTNHSTTIV KNGIKVQTVT ILGKECGVGD
EVRVQNCVCL PFKELKRDVA NEVIM
//
