ID U7UIS8_9FIRM Unreviewed; 421 AA.
AC U7UIS8;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 24-JAN-2024, entry version 32.
DE SubName: Full=Hexokinase {ECO:0000313|EMBL:ERT59235.1};
GN ORFNames=HMPREF1250_1470 {ECO:0000313|EMBL:ERT59235.1};
OS Megasphaera vaginalis.
OC Bacteria; Bacillota; Negativicutes; Veillonellales; Veillonellaceae;
OC Megasphaera.
OX NCBI_TaxID=1111454 {ECO:0000313|EMBL:ERT59235.1, ECO:0000313|Proteomes:UP000017090};
RN [1] {ECO:0000313|EMBL:ERT59235.1, ECO:0000313|Proteomes:UP000017090}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BV3C16-1 {ECO:0000313|EMBL:ERT59235.1,
RC ECO:0000313|Proteomes:UP000017090};
RA Durkin A.S., Haft D.R., McCorrison J., Torralba M., Gillis M., Haft D.H.,
RA Methe B., Sutton G., Nelson K.E.;
RL Submitted (SEP-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + D-fructose = ADP + D-fructose 6-phosphate + H(+);
CC Xref=Rhea:RHEA:16125, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:37721, ChEBI:CHEBI:61527, ChEBI:CHEBI:456216; EC=2.7.1.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001397};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16126;
CC Evidence={ECO:0000256|ARBA:ARBA00001397};
CC -!- PATHWAY: Carbohydrate degradation. {ECO:0000256|ARBA:ARBA00004921}.
CC -!- PATHWAY: Carbohydrate metabolism. {ECO:0000256|ARBA:ARBA00005007}.
CC -!- SIMILARITY: Belongs to the hexokinase family.
CC {ECO:0000256|ARBA:ARBA00009225}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ERT59235.1}.
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DR EMBL; AWXA01000037; ERT59235.1; -; Genomic_DNA.
DR RefSeq; WP_023053862.1; NZ_AWXA01000037.1.
DR AlphaFoldDB; U7UIS8; -.
DR STRING; 1111454.HMPREF1250_1470; -.
DR PATRIC; fig|1111454.3.peg.1390; -.
DR eggNOG; COG5026; Bacteria.
DR OrthoDB; 6383434at2; -.
DR UniPathway; UPA00109; UER00180.
DR Proteomes; UP000017090; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0005536; F:glucose binding; IEA:InterPro.
DR GO; GO:0004396; F:hexokinase activity; IEA:InterPro.
DR GO; GO:0006096; P:glycolytic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0001678; P:intracellular glucose homeostasis; IEA:InterPro.
DR Gene3D; 3.30.420.40; -; 1.
DR Gene3D; 3.40.367.20; -; 1.
DR InterPro; IPR043129; ATPase_NBD.
DR InterPro; IPR001312; Hexokinase.
DR InterPro; IPR022673; Hexokinase_C.
DR InterPro; IPR022672; Hexokinase_N.
DR PANTHER; PTHR19443; HEXOKINASE; 1.
DR PANTHER; PTHR19443:SF16; HEXOKINASE TYPE 1-RELATED; 1.
DR Pfam; PF00349; Hexokinase_1; 1.
DR Pfam; PF03727; Hexokinase_2; 1.
DR PRINTS; PR00475; HEXOKINASE.
DR SUPFAM; SSF53067; Actin-like ATPase domain; 2.
DR PROSITE; PS51748; HEXOKINASE_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:ERT59235.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000017090};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 14..194
FT /note="Hexokinase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00349"
FT DOMAIN 218..412
FT /note="Hexokinase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03727"
SQ SEQUENCE 421 AA; 45211 MW; 8DEF3B7617FFA7C8 CRC64;
MATIRKDDRS AWAEWFYWTD DRLKTFSAAF QHELERALNG VEAAFSVQPS YLPLPAGTEQ
GLYLALTFVG TKVSVGRVRL FGKGYYILEK TVQRPVRKAC YDDADAGTTA ASFFDFLAAA
VAECVGTTPP CALGLTVPFA VAPPSPREAQ LLRPLTGKAA GELLQQALER RGLARCRVKA
VVNDAAASLL AAAYRYGDVA VGVVCDAGFT VCWYEPRRQM LVHAAAASFS ELTGTVWDRR
VDEASPQPGR QVLGKMIGGA YLAEIYRHVL CDYFDCADIP FFTTAEMNGL LQTSCLRETR
HCMGRLWNRL VPPADVEHLC KIGASIFVRS AQLAGASVSA VLRHVYGNAV IPRQKIAVAG
GVLTEVRGSL AVMADGMQAC LAAEPSRTQA LPAYPAISRN GELVGAAVAA AMVGGEDQHC
G
//
