ID U7UT31_9FIRM Unreviewed; 658 AA.
AC U7UT31;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 24-JAN-2024, entry version 30.
DE SubName: Full=Penicillin-binding protein, transpeptidase domain protein {ECO:0000313|EMBL:ERT62592.1};
GN ORFNames=HMPREF1250_0381 {ECO:0000313|EMBL:ERT62592.1};
OS Megasphaera vaginalis.
OC Bacteria; Bacillota; Negativicutes; Veillonellales; Veillonellaceae;
OC Megasphaera.
OX NCBI_TaxID=1111454 {ECO:0000313|EMBL:ERT62592.1, ECO:0000313|Proteomes:UP000017090};
RN [1] {ECO:0000313|EMBL:ERT62592.1, ECO:0000313|Proteomes:UP000017090}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BV3C16-1 {ECO:0000313|EMBL:ERT62592.1,
RC ECO:0000313|Proteomes:UP000017090};
RA Durkin A.S., Haft D.R., McCorrison J., Torralba M., Gillis M., Haft D.H.,
RA Methe B., Sutton G., Nelson K.E.;
RL Submitted (SEP-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the transpeptidase family.
CC {ECO:0000256|ARBA:ARBA00007171}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ERT62592.1}.
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DR EMBL; AWXA01000003; ERT62592.1; -; Genomic_DNA.
DR RefSeq; WP_023052582.1; NZ_AWXA01000003.1.
DR AlphaFoldDB; U7UT31; -.
DR STRING; 1111454.HMPREF1250_0381; -.
DR PATRIC; fig|1111454.3.peg.31; -.
DR eggNOG; COG0768; Bacteria.
DR OrthoDB; 9770103at2; -.
DR Proteomes; UP000017090; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR Gene3D; 3.30.450.330; -; 1.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR005543; PASTA_dom.
DR InterPro; IPR005311; PBP_dimer.
DR InterPro; IPR036138; PBP_dimer_sf.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR PANTHER; PTHR30627:SF1; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE FTSI; 1.
DR Pfam; PF03793; PASTA; 1.
DR Pfam; PF03717; PBP_dimer; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF56519; Penicillin binding protein dimerisation domain; 1.
DR SUPFAM; SSF54184; Penicillin-binding protein 2x (pbp-2x), c-terminal domain; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000017090};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 19..37
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 61..209
FT /note="Penicillin-binding protein dimerisation"
FT /evidence="ECO:0000259|Pfam:PF03717"
FT DOMAIN 254..561
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
FT DOMAIN 605..656
FT /note="PASTA"
FT /evidence="ECO:0000259|Pfam:PF03793"
FT REGION 575..594
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 658 AA; 72353 MW; F774FD07C70ACE8B CRC64;
MLLNTNDSHH KKIRKRISFC GRCLLIVCCL IAGRLGWLQI VQGGSLAERA DAQTEEDRKL
QSPRGMILDR DGKILAISEV TKSLYADPTM IEKTPAEMAK YIAPYSHFSE AELTERLSRD
TAFVWLDRTM DHDKYKALEE VIRKENLKGL RFIDENRRYY PNGTLAAQLI GFVGDNDHGL
DGIEMVLDKD IRGDIKNQRL TTDRNNIPIL ESALAQVLPD QERSVHLTID TTIQFVAERG
LDGIMKENHP EGAAIIVMNP KTGEILAMAS RPNFDPNDFG KGSPAAYKNR AVVNLYEPGS
TFKPIMAAAA VDSGKWGLHD TYDDVGYIDV DDRTIHNWDD AGMGKVTLKE ILMYSINTGM
ANIGIHTGGK ILTDYAKRFG FGKATGIELP GEGEGILFDP DKMSNIDEAT MAIGQSIAVT
PLQMVQAFGA IANRGHMMKP FVIREVDNPD GSVYKRTEPE EVGQPISEDV SRAISKIMAE
EISSGGGQNA KIEGYQFCGK TGTAQRLNAE GTGYAEGQYI GSFIGFGPLE DPQYVVLIVV
DNPNGTYYGA QVAAPVFKEM MTDIVRFKGV APSGSIDSGN IPRDTEQKKT RTMPDVKTTD
QGILLPSFIG WNNREVNDWL NRAGLGFVPN GSGNAVYQDP PAEAYAEPGS DVFVTFMR
//
