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Database: UniProt
Entry: U7UTC5_9FIRM
LinkDB: U7UTC5_9FIRM
Original site: U7UTC5_9FIRM 
ID   U7UTC5_9FIRM            Unreviewed;       150 AA.
AC   U7UTC5;
DT   22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT   22-JAN-2014, sequence version 1.
DT   24-JAN-2024, entry version 32.
DE   RecName: Full=6-carboxy-5,6,7,8-tetrahydropterin synthase {ECO:0000256|ARBA:ARBA00018141};
DE            EC=4.1.2.50 {ECO:0000256|ARBA:ARBA00012982};
DE   AltName: Full=Queuosine biosynthesis protein QueD {ECO:0000256|ARBA:ARBA00031449};
GN   ORFNames=HMPREF1250_0388 {ECO:0000313|EMBL:ERT62576.1};
OS   Megasphaera vaginalis.
OC   Bacteria; Bacillota; Negativicutes; Veillonellales; Veillonellaceae;
OC   Megasphaera.
OX   NCBI_TaxID=1111454 {ECO:0000313|EMBL:ERT62576.1, ECO:0000313|Proteomes:UP000017090};
RN   [1] {ECO:0000313|EMBL:ERT62576.1, ECO:0000313|Proteomes:UP000017090}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BV3C16-1 {ECO:0000313|EMBL:ERT62576.1,
RC   ECO:0000313|Proteomes:UP000017090};
RA   Durkin A.S., Haft D.R., McCorrison J., Torralba M., Gillis M., Haft D.H.,
RA   Methe B., Sutton G., Nelson K.E.;
RL   Submitted (SEP-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=7,8-dihydroneopterin 3'-triphosphate + H2O = 6-
CC         carboxy-5,6,7,8-tetrahydropterin + acetaldehyde + 2 H(+) +
CC         triphosphate; Xref=Rhea:RHEA:27966, ChEBI:CHEBI:15343,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:18036,
CC         ChEBI:CHEBI:58462, ChEBI:CHEBI:61032; EC=4.1.2.50;
CC         Evidence={ECO:0000256|ARBA:ARBA00001293};
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|PIRSR:PIRSR006113-2};
CC       Note=Binds 1 zinc ion per subunit. {ECO:0000256|PIRSR:PIRSR006113-2};
CC   -!- PATHWAY: Purine metabolism; 7-cyano-7-deazaguanine biosynthesis.
CC       {ECO:0000256|ARBA:ARBA00005061}.
CC   -!- SIMILARITY: Belongs to the PTPS family. QueD subfamily.
CC       {ECO:0000256|ARBA:ARBA00008900}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:ERT62576.1}.
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DR   EMBL; AWXA01000003; ERT62576.1; -; Genomic_DNA.
DR   RefSeq; WP_023052566.1; NZ_AWXA01000003.1.
DR   AlphaFoldDB; U7UTC5; -.
DR   STRING; 1111454.HMPREF1250_0388; -.
DR   PATRIC; fig|1111454.3.peg.38; -.
DR   eggNOG; COG0720; Bacteria.
DR   OrthoDB; 9804698at2; -.
DR   UniPathway; UPA00391; -.
DR   Proteomes; UP000017090; Unassembled WGS sequence.
DR   GO; GO:0070497; F:6-carboxy-5,6,7,8-tetrahydropterin synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.479.10; 6-pyruvoyl tetrahydropterin synthase/QueD; 1.
DR   InterPro; IPR007115; 6-PTP_synth/QueD.
DR   InterPro; IPR038418; 6-PTP_synth/QueD_sf.
DR   PANTHER; PTHR12589:SF8; 6-CARBOXY-5,6,7,8-TETRAHYDROPTERIN SYNTHASE; 1.
DR   PANTHER; PTHR12589; PYRUVOYL TETRAHYDROBIOPTERIN SYNTHASE; 1.
DR   Pfam; PF01242; PTPS; 1.
DR   PIRSF; PIRSF006113; PTP_synth; 2.
DR   SUPFAM; SSF55620; Tetrahydrobiopterin biosynthesis enzymes-like; 1.
PE   3: Inferred from homology;
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR006113-2};
KW   Reference proteome {ECO:0000313|Proteomes:UP000017090};
KW   Zinc {ECO:0000256|PIRSR:PIRSR006113-2}.
FT   ACT_SITE        23
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR006113-1"
FT   ACT_SITE        70
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR006113-1"
FT   ACT_SITE        128
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR006113-1"
FT   BINDING         14
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR006113-2"
FT   BINDING         27
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR006113-2"
FT   BINDING         29
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR006113-2"
SQ   SEQUENCE   150 AA;  17238 MW;  18382A956E64BEA7 CRC64;
     MFYLECEECF DAAHFLRDYD GKCRNIHGHR WRVIAQAGGV LQQEKQTRGM VMDFAVLRTA
     LKDICRKLDH SLIYEKDSLR ERTLTALREE SMLLTEVPFR PTAENFAAHF FSLLTARGVA
     VTAVKVYETP NNCAVYTGEL NASSREIHQH
//
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