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Database: UniProt
Entry: URE2_NATPD
LinkDB: URE2_NATPD
Original site: URE2_NATPD 
ID   URE2_NATPD              Reviewed;         132 AA.
AC   Q3IRZ6;
DT   02-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   08-NOV-2005, sequence version 1.
DT   08-MAY-2019, entry version 86.
DE   RecName: Full=Urease subunit beta {ECO:0000255|HAMAP-Rule:MF_01954};
DE            EC=3.5.1.5 {ECO:0000255|HAMAP-Rule:MF_01954};
DE   AltName: Full=Urea amidohydrolase subunit beta {ECO:0000255|HAMAP-Rule:MF_01954};
GN   Name=ureB {ECO:0000255|HAMAP-Rule:MF_01954};
GN   OrderedLocusNames=NP_2008A;
OS   Natronomonas pharaonis (strain ATCC 35678 / DSM 2160 / CIP 103997 /
OS   NBRC 14720 / NCIMB 2260 / Gabara) (Halobacterium pharaonis).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria;
OC   Halobacteriales; Haloarculaceae; Natronomonas.
OX   NCBI_TaxID=348780;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35678 / DSM 2160 / CIP 103997 / NBRC 14720 / NCIMB 2260 /
RC   Gabara;
RX   PubMed=16169924; DOI=10.1101/gr.3952905;
RA   Falb M., Pfeiffer F., Palm P., Rodewald K., Hickmann V., Tittor J.,
RA   Oesterhelt D.;
RT   "Living with two extremes: conclusions from the genome sequence of
RT   Natronomonas pharaonis.";
RL   Genome Res. 15:1336-1343(2005).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2 H(+) + H2O + urea = CO2 + 2 NH4(+);
CC         Xref=Rhea:RHEA:20557, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16199, ChEBI:CHEBI:16526, ChEBI:CHEBI:28938;
CC         EC=3.5.1.5; Evidence={ECO:0000255|HAMAP-Rule:MF_01954};
CC   -!- PATHWAY: Nitrogen metabolism; urea degradation; CO(2) and NH(3)
CC       from urea (urease route): step 1/1. {ECO:0000255|HAMAP-
CC       Rule:MF_01954}.
CC   -!- SUBUNIT: Heterotrimer of UreA (gamma), UreB (beta) and UreC
CC       (alpha) subunits. Three heterotrimers associate to form the active
CC       enzyme. {ECO:0000255|HAMAP-Rule:MF_01954}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01954}.
CC   -!- SIMILARITY: Belongs to the urease beta subunit family.
CC       {ECO:0000255|HAMAP-Rule:MF_01954}.
DR   EMBL; CR936257; CAI49095.1; -; Genomic_DNA.
DR   RefSeq; WP_011322724.1; NC_007426.1.
DR   SMR; Q3IRZ6; -.
DR   STRING; 348780.NP_2008A; -.
DR   GeneID; 3703449; -.
DR   KEGG; nph:NP_2008A; -.
DR   eggNOG; arCOG04527; Archaea.
DR   eggNOG; COG0832; LUCA.
DR   HOGENOM; HOG000077770; -.
DR   KO; K01429; -.
DR   OMA; FYEVNDA; -.
DR   OrthoDB; 108153at2157; -.
DR   BioCyc; NPHA348780:G1GI2-998-MONOMER; -.
DR   UniPathway; UPA00258; UER00370.
DR   Proteomes; UP000002698; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009039; F:urease activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0043419; P:urea catabolic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd00407; Urease_beta; 1.
DR   Gene3D; 2.10.150.10; -; 1.
DR   HAMAP; MF_01954; Urease_beta; 1.
DR   InterPro; IPR002019; Urease_beta.
DR   InterPro; IPR036461; Urease_betasu_sf.
DR   Pfam; PF00699; Urease_beta; 1.
DR   SUPFAM; SSF51278; SSF51278; 1.
DR   TIGRFAMs; TIGR00192; urease_beta; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Cytoplasm; Hydrolase; Reference proteome.
FT   CHAIN         1    132       Urease subunit beta.
FT                                /FTId=PRO_0000234284.
SQ   SEQUENCE   132 AA;  14144 MW;  FED3BE2C187922EB CRC64;
     MSDPSEGSLT PGELLVDDAP VELNAGRETA TVTVENTGDR PVQVGSHYHF FETNPALAFD
     RETAYGMRLN IPAGTAVRFE PGAERDVELV AIGGDRIVHG MDGLVNGDLD DEATRERAMD
     RAAAAGYRGV ER
//
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