ID UVRC_BORA1 Reviewed; 607 AA.
AC Q2KXM9;
DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT 12-DEC-2006, sequence version 2.
DT 24-JAN-2024, entry version 98.
DE RecName: Full=UvrABC system protein C {ECO:0000255|HAMAP-Rule:MF_00203};
DE Short=Protein UvrC {ECO:0000255|HAMAP-Rule:MF_00203};
DE AltName: Full=Excinuclease ABC subunit C {ECO:0000255|HAMAP-Rule:MF_00203};
GN Name=uvrC {ECO:0000255|HAMAP-Rule:MF_00203}; OrderedLocusNames=BAV2456;
OS Bordetella avium (strain 197N).
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Alcaligenaceae; Bordetella.
OX NCBI_TaxID=360910;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=197N;
RX PubMed=16885469; DOI=10.1128/jb.01927-05;
RA Sebaihia M., Preston A., Maskell D.J., Kuzmiak H., Connell T.D., King N.D.,
RA Orndorff P.E., Miyamoto D.M., Thomson N.R., Harris D., Goble A., Lord A.,
RA Murphy L., Quail M.A., Rutter S., Squares R., Squares S., Woodward J.,
RA Parkhill J., Temple L.M.;
RT "Comparison of the genome sequence of the poultry pathogen Bordetella avium
RT with those of B. bronchiseptica, B. pertussis, and B. parapertussis reveals
RT extensive diversity in surface structures associated with host
RT interaction.";
RL J. Bacteriol. 188:6002-6015(2006).
CC -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC lesion. The N-terminal half is responsible for the 3' incision and the
CC C-terminal half is responsible for the 5' incision. {ECO:0000255|HAMAP-
CC Rule:MF_00203}.
CC -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC {ECO:0000255|HAMAP-Rule:MF_00203}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00203}.
CC -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000255|HAMAP-
CC Rule:MF_00203}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAJ50066.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AM167904; CAJ50066.1; ALT_INIT; Genomic_DNA.
DR RefSeq; WP_039051595.1; NC_010645.1.
DR AlphaFoldDB; Q2KXM9; -.
DR SMR; Q2KXM9; -.
DR STRING; 360910.BAV2456; -.
DR GeneID; 41394294; -.
DR KEGG; bav:BAV2456; -.
DR eggNOG; COG0322; Bacteria.
DR HOGENOM; CLU_014841_3_0_4; -.
DR OrthoDB; 9804933at2; -.
DR Proteomes; UP000001977; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR CDD; cd10434; GIY-YIG_UvrC_Cho; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR Gene3D; 3.40.1440.10; GIY-YIG endonuclease; 1.
DR Gene3D; 4.10.860.10; UVR domain; 1.
DR Gene3D; 3.30.420.340; UvrC, RNAse H endonuclease domain; 1.
DR HAMAP; MF_00203; UvrC; 1.
DR InterPro; IPR000305; GIY-YIG_endonuc.
DR InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR InterPro; IPR047296; GIY-YIG_UvrC_Cho.
DR InterPro; IPR003583; Hlx-hairpin-Hlx_DNA-bd_motif.
DR InterPro; IPR010994; RuvA_2-like.
DR InterPro; IPR001943; UVR_dom.
DR InterPro; IPR036876; UVR_dom_sf.
DR InterPro; IPR004791; UvrC.
DR InterPro; IPR001162; UvrC_RNase_H_dom.
DR InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR NCBIfam; TIGR00194; uvrC; 1.
DR PANTHER; PTHR30562:SF1; UVRABC SYSTEM PROTEIN C; 1.
DR PANTHER; PTHR30562; UVRC/OXIDOREDUCTASE; 1.
DR Pfam; PF01541; GIY-YIG; 1.
DR Pfam; PF14520; HHH_5; 1.
DR Pfam; PF02151; UVR; 1.
DR Pfam; PF08459; UvrC_RNaseH_dom; 1.
DR SMART; SM00465; GIYc; 1.
DR SMART; SM00278; HhH1; 2.
DR SUPFAM; SSF46600; C-terminal UvrC-binding domain of UvrB; 1.
DR SUPFAM; SSF82771; GIY-YIG endonuclease; 1.
DR SUPFAM; SSF47781; RuvA domain 2-like; 1.
DR PROSITE; PS50164; GIY_YIG; 1.
DR PROSITE; PS50151; UVR; 1.
DR PROSITE; PS50165; UVRC; 1.
PE 3: Inferred from homology;
KW Cytoplasm; DNA damage; DNA excision; DNA repair; Excision nuclease;
KW Reference proteome; SOS response.
FT CHAIN 1..607
FT /note="UvrABC system protein C"
FT /id="PRO_0000264870"
FT DOMAIN 16..94
FT /note="GIY-YIG"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT DOMAIN 203..238
FT /note="UVR"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
SQ SEQUENCE 607 AA; 66965 MW; 2A8ABF1DB1BB5FA9 CRC64;
MPDEFNLKSF LADLPHLPGV YRHLDAAGEV MYVGKARDLK KRVSSYFQKT LASPRIAQMV
SKVVRLEVTV TRSEAEALIL ENNLIKSLRP RYNILFRDDK SYPYLLITAH EWPRIAYYRG
STSKRGQYFG PYPNSWAVRE TIQILQKVFR LRTCEDTVFA NRSRPCLLYQ IGRCSGPCVQ
AIDAEDYRRD VQRAARFLNG EAREVMDEIE ARMQQASGEL RFEEAAVLRD QMGSLSKVLH
QQTMENVGGE DTDVIAVASA GGKVCVNLAM VRGGRHLGDK PFFPSHADGE EAAQVQEAFI
AQHYADNVLP PVLVCSHALP DVDLIGLLSE QAGTRCRVLT RPQGVRRSWL EQAQKNAEMA
LARALTESGA RAARTLSLAE ALDLDTDEAA LDALRIECFD ISHTAGEATQ ASCVVFLHHD
MQPSLYRRYN IVGITPGDDY AAMRQVLTRR FAKVTDGEAP MPGLVLIDGG KGQVEVARQV
FVELGLDIGA LVGVAKGEGR KVGLETLVFA DARAPLALGK ASAALMLIAQ VRDEAHRFAI
TGMRAKRAKT RNVSRLEEIE GVGAKRRQRL LARFGGLSGV TSASIEDLAS VDGISMDLAE
RIYDALH
//
