ID V1CMF2_9FIRM Unreviewed; 550 AA.
AC V1CMF2;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=Orn/Lys/Arg decarboxylase, major domain protein {ECO:0000313|EMBL:ESE29920.1};
GN ORFNames=HMPREF9089_00954 {ECO:0000313|EMBL:ESE29920.1};
OS Eubacterium brachy ATCC 33089.
OC Bacteria; Bacillota; Clostridia; Eubacteriales;
OC Eubacteriales Family XIII. Incertae Sedis.
OX NCBI_TaxID=1321814 {ECO:0000313|EMBL:ESE29920.1, ECO:0000313|Proteomes:UP000017536};
RN [1] {ECO:0000313|EMBL:ESE29920.1, ECO:0000313|Proteomes:UP000017536}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 33089 {ECO:0000313|EMBL:ESE29920.1,
RC ECO:0000313|Proteomes:UP000017536};
RA Weinstock G., Sodergren E., Wylie T., Fulton L., Fulton R., Fronick C.,
RA O'Laughlin M., Godfrey J., Miner T., Herter B., Appelbaum E., Cordes M.,
RA Lek S., Wollam A., Pepin K.H., Palsikar V.B., Mitreva M., Wilson R.K.;
RL Submitted (AUG-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000256|ARBA:ARBA00001933};
CC -!- SIMILARITY: Belongs to the Orn/Lys/Arg decarboxylase class-I family.
CC {ECO:0000256|ARBA:ARBA00010671}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ESE29920.1}.
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DR EMBL; AXUD01000007; ESE29920.1; -; Genomic_DNA.
DR AlphaFoldDB; V1CMF2; -.
DR STRING; 1321814.HMPREF9089_00954; -.
DR PATRIC; fig|1321814.3.peg.910; -.
DR eggNOG; COG1982; Bacteria.
DR HOGENOM; CLU_025925_2_1_9; -.
DR Proteomes; UP000017536; Unassembled WGS sequence.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR Gene3D; 3.90.105.10; Molybdopterin biosynthesis moea protein, domain 2; 1.
DR Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR InterPro; IPR000310; Orn/Lys/Arg_deCO2ase_major_dom.
DR InterPro; IPR008286; Prn/Lys/Arg_de-COase_C.
DR InterPro; IPR036633; Prn/Lys/Arg_de-COase_C_sf.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR PANTHER; PTHR43277; ARGININE DECARBOXYLASE; 1.
DR PANTHER; PTHR43277:SF3; LYSINE DECARBOXYLASE; 1.
DR Pfam; PF01276; OKR_DC_1; 2.
DR Pfam; PF03711; OKR_DC_1_C; 1.
DR SUPFAM; SSF55904; Ornithine decarboxylase C-terminal domain; 1.
DR SUPFAM; SSF53383; PLP-dependent transferases; 1.
PE 3: Inferred from homology;
KW Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898};
KW Reference proteome {ECO:0000313|Proteomes:UP000017536}.
FT DOMAIN 2..186
FT /note="Orn/Lys/Arg decarboxylases family 1 pyridoxal-P
FT attachment site"
FT /evidence="ECO:0000259|Pfam:PF01276"
FT DOMAIN 227..306
FT /note="Orn/Lys/Arg decarboxylases family 1 pyridoxal-P
FT attachment site"
FT /evidence="ECO:0000259|Pfam:PF01276"
FT DOMAIN 479..524
FT /note="Orn/Lys/Arg decarboxylase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03711"
FT REGION 420..440
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 550 AA; 61591 MW; CD7B9B99BD134736 CRC64;
MPGHKGLGIF NMYGYGELMK NLVNMDITEI SGADNLHKPK GVIKNLEDKY AELYGAKKTF
LLIDGSTAGI LASIMACVPT GKKILAARNC HKSVYSGTVL TKCVPTYVMP KHDKTSHVMG
EITAEDVRRI LEGDFRDKDE IYAVILASPN YYGICSNVEE IAEVVHRYGK VLIVDQAHGA
HLKFFEKNGY VDDLKKDSVG ERNIERGDRN YRYLTYPRSA ESSGADIVIN STHKTLSSFT
QSAVLNVMTD RVDERNIFDK LQLIQSTSPS YILMLSLDIN ADIIEKHGDE VFENWKNNVK
RFYEQMAKIP EVTVVEDENL DWTKINLSLE KMGIDGGTFE KLLTDRGIDV ELAAGNIVMA
LTGIGNSLED YDKLLDAVKD IVWSIKERRK SNLRENVDCN SRESSVCDMD IRRRRSEIDA
DERKETCGDE NSTSDEQLNK TGCKGDESMI KFSVEDSDCI SVDKGFSIPK PGEYIGQEGE
SAEVYLRDSM GCISKDAIIP YPPGIPFVCP GEIITEECVK RLLQLMGENK DIFGISREGK
IRIIIGEDKQ
//
