ID V2TBF9_9GAMM Unreviewed; 1047 AA.
AC V2TBF9;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=Cation efflux system protein CzcA {ECO:0008006|Google:ProtNLM};
GN ORFNames=P256_00397 {ECO:0000313|EMBL:ESK39958.1};
OS Acinetobacter nectaris CIP 110549.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Moraxellales; Moraxellaceae;
OC Acinetobacter.
OX NCBI_TaxID=1392540 {ECO:0000313|EMBL:ESK39958.1, ECO:0000313|Proteomes:UP000023785};
RN [1] {ECO:0000313|EMBL:ESK39958.1, ECO:0000313|Proteomes:UP000023785}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CIP 110549 {ECO:0000313|EMBL:ESK39958.1,
RC ECO:0000313|Proteomes:UP000023785};
RG The Broad Institute Genomics Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Cerqueira G., Feldgarden M., Courvalin P., Grillot-Courvalin C.,
RA Clermont D., Rocha E., Yoon E.-J., Nemec A., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Abouelleil A., Alvarado L., Berlin A.M.,
RA Chapman S.B., Gainer-Dewar J., Goldberg J., Gnerre S., Griggs A., Gujja S.,
RA Hansen M., Howarth C., Imamovic A., Ireland A., Larimer J., McCowan C.,
RA Murphy C., Pearson M., Poon T.W., Priest M., Roberts A., Saif S., Shea T.,
RA Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Acinetobacter nectaris CIP 110549.";
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC (TC 2.A.6) family. {ECO:0000256|ARBA:ARBA00010942}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ESK39958.1}.
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DR EMBL; AYER01000003; ESK39958.1; -; Genomic_DNA.
DR RefSeq; WP_023272000.1; NZ_KI530712.1.
DR AlphaFoldDB; V2TBF9; -.
DR STRING; 1392540.P256_00397; -.
DR PATRIC; fig|1392540.3.peg.388; -.
DR eggNOG; COG3696; Bacteria.
DR HOGENOM; CLU_002755_1_2_6; -.
DR OrthoDB; 9758757at2; -.
DR Proteomes; UP000023785; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008324; F:monoatomic cation transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 3.30.70.1430; Multidrug efflux transporter AcrB pore domain; 2.
DR Gene3D; 3.30.70.1440; Multidrug efflux transporter AcrB pore domain; 1.
DR Gene3D; 3.30.70.1320; Multidrug efflux transporter AcrB pore domain like; 1.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR027463; AcrB_DN_DC_subdom.
DR InterPro; IPR001036; Acrflvin-R.
DR InterPro; IPR004763; CusA-like.
DR NCBIfam; TIGR00914; 2A0601; 1.
DR PANTHER; PTHR32063; -; 1.
DR PANTHER; PTHR32063:SF24; CATION EFFLUX SYSTEM (ACRB_ACRD_ACRF FAMILY); 1.
DR Pfam; PF00873; ACR_tran; 1.
DR PRINTS; PR00702; ACRIFLAVINRP.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000023785};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 27..45
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 357..376
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 466..486
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 498..521
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 542..570
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 890..907
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 914..933
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 939..964
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 985..1004
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1016..1039
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 1047 AA; 115324 MW; EAE162231A6902FF CRC64;
MGTKHDDTFP KSKGIFDSII QFSIQNALWV ILFTLIWIAI GVFSYQRLSI DAVPDITNVQ
VQINSEAKGF TALETEQRIT YPIENEMAGI PDLQQTRSIS RYGLSQITVI FKDGTDIYWA
RQQITERLQK VRGEMPLSVE PKISPVSTGL GEIYQWVIRA DTNAKKPDGS VYSPMDLREI
QDWIVKPQIQ RLSGVAEVNS IGGYDKNYIV SPNLSRLQQL GISLNQITEV LEQNNENKGA
GFVENNGQQL TVRVPGVLKT VSDIENVVVQ NKGNTPIRIS DIATVSIGHD LRTGGATYNG
KEAVLGIAMM MMGENSRTVA QTVHKKVQEI QKTLPKGVVI ETVYDRTNLV DKAIKTVVKN
LIEGAVLVIV ILFIFLGNFR AALITACIIP LSMLFTLTGM AEQKISANLM SLGALDFGII
IDGAVVIIEN CIRRLANAQH EKGRLLTRKE RFREVFLAAQ QARRPLIFGQ LIIMVVYIPI
FALTGVEAKL FHPMAMTVVL ALVGAMILSL TFVPAAVALC VTGKVSEKES RWMIKLKEIY
LLVLDITYAY KAILIAVVIS ILCITGTIAF KMGTEFTPKL SEGDFAIQFM RAPSTGIEQS
LQMQEKVEQQ LIQNFPEVKA IFARTGTAEV ATDVMPPNIS DSIVLLKPQA EWSNPKETIS
DLRQRMMAYV EHIPGNANEF SQPIELRFNE LISGVRSDIG VKIFGDDLNV LADEAQKVEK
RLKTIDGASE VKIEQTQGLP MLNVDIQHDK IAQYGLSTKM IQDWVAMATG GQSVGKILQG
DRRFDFVVRL SPTLNSLEQL QQLPISLPGG GSIVLKDVAK VEEVSGISQI SREEGKRRIV
ITANVRNRDL GSFVQEVQQV MQQQKLAAGY WMSYGGQFEN LQSAAQRMQI VVPIALTLIF
VLLVAVFGRL QESLLVFMGV PFALSGGVVA LWLRDIPFSM SAGIGFIALS GVAVLNGLVM
LTFIKELAQS HSLVQAIWQG AILRLRPVLM TACVASLGFV PMALATGTGA EVQQPLATVV
IGGIVSSTLL TLIVVPIVYR WWNERKS
//
