ID V2TJS4_9GAMM Unreviewed; 780 AA.
AC V2TJS4;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
DE Flags: Fragment;
GN ORFNames=P256_02591 {ECO:0000313|EMBL:ESK35805.1};
OS Acinetobacter nectaris CIP 110549.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Moraxellales; Moraxellaceae;
OC Acinetobacter.
OX NCBI_TaxID=1392540 {ECO:0000313|EMBL:ESK35805.1, ECO:0000313|Proteomes:UP000023785};
RN [1] {ECO:0000313|EMBL:ESK35805.1, ECO:0000313|Proteomes:UP000023785}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CIP 110549 {ECO:0000313|EMBL:ESK35805.1,
RC ECO:0000313|Proteomes:UP000023785};
RG The Broad Institute Genomics Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Cerqueira G., Feldgarden M., Courvalin P., Grillot-Courvalin C.,
RA Clermont D., Rocha E., Yoon E.-J., Nemec A., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Abouelleil A., Alvarado L., Berlin A.M.,
RA Chapman S.B., Gainer-Dewar J., Goldberg J., Gnerre S., Griggs A., Gujja S.,
RA Hansen M., Howarth C., Imamovic A., Ireland A., Larimer J., McCowan C.,
RA Murphy C., Pearson M., Poon T.W., Priest M., Roberts A., Saif S., Shea T.,
RA Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Acinetobacter nectaris CIP 110549.";
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ESK35805.1}.
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DR EMBL; AYER01000020; ESK35805.1; -; Genomic_DNA.
DR AlphaFoldDB; V2TJS4; -.
DR STRING; 1392540.P256_02591; -.
DR eggNOG; COG1074; Bacteria.
DR HOGENOM; CLU_001114_6_0_6; -.
DR OrthoDB; 9810135at2; -.
DR Proteomes; UP000023785; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-UniRule.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 1.10.3170.10; Recbcd, chain B, domain 2; 1.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF23; RECBCD ENZYME SUBUNIT RECB; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000023785}.
FT DOMAIN 5..494
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 495..780
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT BINDING 26..33
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
FT NON_TER 780
FT /evidence="ECO:0000313|EMBL:ESK35805.1"
SQ SEQUENCE 780 AA; 90695 MW; 7C4AEDC9165CFBD2 CRC64;
MKPTVREVSF QPIQDIQFQG LHWIEASAGS GKTFTLSSLL VRILLEKHLP KQVVATTFTR
AAAAELKQRI RMRLVEIHQF FKERQGFDDQ ANIEHFKQLK VEGADPLKIV LLEKFSTQVA
YACSRLQLVL EQLDELFVGT LDSFSQKLLR EFAFESGKIE RIDITDQSKQ YTEQLIHDVL
REWLQKQSQQ QVDWFYMSGR LKPTHQYIKI VEDALNFTSA YFKPVQPPKI EVDQFLKLRD
KLRNLSFAHL SSYYLADGNF FPTVSKTIFR QNSFTVLFEQ IIPEAIERIL KEDGRHFFLK
EFTDARTTLE KFVKNIQDGK VFTKKCAEQD ATRFYTDEAL QKLVDVLAHT QHMESALVET
EGYLKYHLCE QVKLRLPALL QQQGETTFAQ QIKTLSEALQ GEQGEHFAAF VQTSYPLILV
DEFQDTNQEQ DNMLASIWRA PTRYEKGCMI MVGDRKQAIY GFRGGDMLTF IRAYHDVISK
KGHFYRLKYN HRTIQPLVEA VDALFMQHPD FGEHVIYEPV EAGTRPHPQL IDGKEQNPTP
LRWLHIESEV QPEIQVAWKI STLLQQSQQG QLYLSKDHSN TPIIADDIAV LSKNHDGLDK
VQFELERLGI RVNRPSKRSV FDGLLAQDVA AVLIAIMNPY DEKKVKRALL SRMLGYTLTN
LNEFERQTDG LGQFISVFSE IREIWFERHF LAAWQYCLRY FDVWRNLVRF DSRDNERSVV
NLRHLSDLLS QHSGKYQGPK NLLNWYLKQV ASPSDREWEL ERSLSTDAGI QLMTIHQSKG
//
