ID V3Z2U5_LOTGI Unreviewed; 865 AA.
AC V3Z2U5;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE RecName: Full=Ionotropic glutamate receptor C-terminal domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=LOTGIDRAFT_131225 {ECO:0000313|EMBL:ESO84923.1};
OS Lottia gigantea (Giant owl limpet).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Patellogastropoda; Lottioidea; Lottiidae; Lottia.
OX NCBI_TaxID=225164 {ECO:0000313|EMBL:ESO84923.1, ECO:0000313|Proteomes:UP000030746};
RN [1] {ECO:0000313|EMBL:ESO84923.1, ECO:0000313|Proteomes:UP000030746}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; KB203357; ESO84923.1; -; Genomic_DNA.
DR RefSeq; XP_009064312.1; XM_009066064.1.
DR AlphaFoldDB; V3Z2U5; -.
DR STRING; 225164.V3Z2U5; -.
DR EnsemblMetazoa; LotgiT131225; LotgiP131225; LotgiG131225.
DR GeneID; 20233168; -.
DR KEGG; lgi:LOTGIDRAFT_131225; -.
DR CTD; 20233168; -.
DR HOGENOM; CLU_002039_3_0_1; -.
DR OMA; DANCALM; -.
DR OrthoDB; 1034721at2759; -.
DR Proteomes; UP000030746; Unassembled WGS sequence.
DR GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-KW.
DR GO; GO:0015276; F:ligand-gated monoatomic ion channel activity; IEA:InterPro.
DR GO; GO:0038023; F:signaling receptor activity; IEA:InterPro.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:UniProt.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 3.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR019594; Glu/Gly-bd.
DR InterPro; IPR001508; Iono_Glu_rcpt_met.
DR InterPro; IPR015683; Ionotropic_Glu_rcpt.
DR InterPro; IPR001320; Iontro_rcpt_C.
DR InterPro; IPR028082; Peripla_BP_I.
DR InterPro; IPR001638; Solute-binding_3/MltF_N.
DR PANTHER; PTHR18966; IONOTROPIC GLUTAMATE RECEPTOR; 1.
DR PANTHER; PTHR18966:SF391; NMDA RECEPTOR 2, ISOFORM C; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF00060; Lig_chan; 1.
DR Pfam; PF10613; Lig_chan-Glu_bd; 1.
DR Pfam; PF00497; SBP_bac_3; 1.
DR PRINTS; PR00177; NMDARECEPTOR.
DR SMART; SM00918; Lig_chan-Glu_bd; 1.
DR SMART; SM00079; PBPe; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Postsynaptic cell membrane {ECO:0000256|ARBA:ARBA00023257};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000030746};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Synapse {ECO:0000256|ARBA:ARBA00023018};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 501..522
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 543..560
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 572..597
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 755..780
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 393..739
FT /note="Ionotropic glutamate receptor C-terminal"
FT /evidence="ECO:0000259|SMART:SM00079"
FT DOMAIN 396..448
FT /note="Ionotropic glutamate receptor L-glutamate and
FT glycine-binding"
FT /evidence="ECO:0000259|SMART:SM00918"
SQ SEQUENCE 865 AA; 98072 MW; 5081EB2CE57FDF99 CRC64;
MTLLKQDSPK EILGSFCDEI FPSNTTTILH INNPMSIRRR PAASQYVKSL GVYFGIPLIT
WDAEDSGGST NRIESRTLQI APTIHHQTKA MFSLLQRYNW TLFSIVTSKT AGHLDFISSL
RALAKSTNKQ TTIEVVTHII LRDTKNATES KAALSQLTKF DSRVILLHAN SLESKYIMDY
AHELGIAGQE FVWILSQTAI PTATYAPRSF HYGLLGISYD HGKEAMIEAI KMGTTIWINA
LNNLATTRGL HTKYKMSPNL SCEGIGKMFW KNGSVFYNYL KNVTVAGPPS ISFNESGILM
TTDLQILNIQ RRDGNKRMWE QVGSWTNKGL IMKDITWPGE AAAPPRGKPE RKFVRVLTLH
ENPYVIYEEP KDGECSRSQA PCHVYERDEN KNRLSNDTIM KCCVGLSIDL LRILSTELDF
DYELKEVEDG QWGAFNPKWN GLPKALADGK GDWVVTSLKI NPERNTIVDF SVPYLETGIT
IIVAIREGAI SATAFLEPYD YPSWTLILVF SVHATGASIF IFEWLSPYGL NQGQTTLREH
KFSLFRSFWL IWAMLFSAAV STDTPRGVSS RFLANMWALF ALVFLASYTA NLAAFMITKE
EYYDLSGIQD YRLKNPHALK PPFKYATIPS GSTETNIKKN HPDMYAYMKR YNVPTVEDGI
MALKKQEIQA FIYDATVLEY LAGKDKGCRL ITVGKWYAMT GYGIAFPYGS PWKDKINKVL
LQLQDMGEME RLQKYWLSGA CNKKKKRKGI KSHTLGILNF TSAFILLALG MMLGAILLGL
EHCYFRFGRS KLKKWDKCGC CTLVSLSMGK SLTFEQSVLE AIQSHRKRRC KDPLCETQLW
KIKHELDLAL LKIDRLEDKR YVFCL
//
