ID V3Z3Y5_LOTGI Unreviewed; 515 AA.
AC V3Z3Y5;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE RecName: Full=FZ domain-containing protein {ECO:0000259|PROSITE:PS50038};
GN ORFNames=LOTGIDRAFT_167918 {ECO:0000313|EMBL:ESO85338.1};
OS Lottia gigantea (Giant owl limpet).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Patellogastropoda; Lottioidea; Lottiidae; Lottia.
OX NCBI_TaxID=225164 {ECO:0000313|EMBL:ESO85338.1, ECO:0000313|Proteomes:UP000030746};
RN [1] {ECO:0000313|EMBL:ESO85338.1, ECO:0000313|Proteomes:UP000030746}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00090}.
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DR EMBL; KB203275; ESO85338.1; -; Genomic_DNA.
DR RefSeq; XP_009064036.1; XM_009065788.1.
DR AlphaFoldDB; V3Z3Y5; -.
DR STRING; 225164.V3Z3Y5; -.
DR EnsemblMetazoa; LotgiT167918; LotgiP167918; LotgiG167918.
DR GeneID; 20240730; -.
DR KEGG; lgi:LOTGIDRAFT_167918; -.
DR CTD; 20240730; -.
DR HOGENOM; CLU_529239_0_0_1; -.
DR OMA; TAPENSW; -.
DR OrthoDB; 5317198at2759; -.
DR Proteomes; UP000030746; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd07066; CRD_FZ; 2.
DR Gene3D; 1.10.2000.10; Frizzled cysteine-rich domain; 2.
DR InterPro; IPR015526; Frizzled/SFRP.
DR InterPro; IPR020067; Frizzled_dom.
DR InterPro; IPR036790; Frizzled_dom_sf.
DR PANTHER; PTHR11309; FRIZZLED; 1.
DR PANTHER; PTHR11309:SF148; SECRETED FRIZZLED-RELATED PROTEIN 1; 1.
DR Pfam; PF01392; Fz; 2.
DR SMART; SM00063; FRI; 2.
DR SUPFAM; SSF63501; Frizzled cysteine-rich domain; 2.
DR PROSITE; PS50038; FZ; 2.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00090}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000030746};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 21..45
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 255..384
FT /note="FZ"
FT /evidence="ECO:0000259|PROSITE:PS50038"
FT DOMAIN 376..487
FT /note="FZ"
FT /evidence="ECO:0000259|PROSITE:PS50038"
FT REGION 182..239
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 491..515
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 391..437
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
SQ SEQUENCE 515 AA; 56552 MW; 9F314081CF0DD814 CRC64;
MQYATTAPEN SWSKKKLKVR NILLIVLGCV LLLALAVGTA VGIVLHTQAS FASTLPPTTP
STTVSDHITY TGTLRLSQPW PDSENTLKYN FTQEINDIMR NSSFQKYYIS STVQKYSPQD
NSIEFTLEFS SDMRGLNLTS DPETDEYANQ IEYIIKTGAI TLPVNVSSII IVDQLPTTTT
KPLPSTKETT TTEMVTSTTE MVTSTTENVT STTEMVPSTL ENATSTTESV TSTTKMTTTE
KPSTTTAAYV IKTSPDPRRC VYQDFELCKE FGNTFTLLPN YFGDESISSA ANTFFTYFNH
TVNSGCSKDV LYYFCNLVFP QCDEVNGTAT AIYPCVSTCD EVTIPCDKEM PFPLDCSFFE
SDPSKCVTPP KDITTPAPKT CQSIEVNYDY CGDLGFNVTS FPSLFGSNIG EVRAAFTSYA
LSTVQSMCHP DVQFFYCGLF FPKCMDGDKL MPCKSLCEEV NAACEESSRF PVDCEIFSND
TQRCLSVNNT NMTPGPSTTP TPSTTTIPLG GTTDI
//
