ID V3ZE65_LOTGI Unreviewed; 335 AA.
AC V3ZE65;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=3-beta hydroxysteroid dehydrogenase/isomerase domain-containing protein {ECO:0000259|Pfam:PF01073};
DE Flags: Fragment;
GN ORFNames=LOTGIDRAFT_125131 {ECO:0000313|EMBL:ESO89403.1};
OS Lottia gigantea (Giant owl limpet).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Patellogastropoda; Lottioidea; Lottiidae; Lottia.
OX NCBI_TaxID=225164 {ECO:0000313|EMBL:ESO89403.1, ECO:0000313|Proteomes:UP000030746};
RN [1] {ECO:0000313|EMBL:ESO89403.1, ECO:0000313|Proteomes:UP000030746}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
CC -!- SIMILARITY: Belongs to the 3-beta-HSD family.
CC {ECO:0000256|ARBA:ARBA00009219, ECO:0000256|RuleBase:RU004475}.
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DR EMBL; KB202591; ESO89403.1; -; Genomic_DNA.
DR RefSeq; XP_009059768.1; XM_009061520.1.
DR AlphaFoldDB; V3ZE65; -.
DR STRING; 225164.V3ZE65; -.
DR EnsemblMetazoa; LotgiT125131; LotgiP125131; LotgiG125131.
DR GeneID; 20232449; -.
DR KEGG; lgi:LOTGIDRAFT_125131; -.
DR CTD; 20232449; -.
DR HOGENOM; CLU_007383_6_8_1; -.
DR OMA; STAHWFD; -.
DR OrthoDB; 1133at2759; -.
DR Proteomes; UP000030746; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0003854; F:3-beta-hydroxy-delta5-steroid dehydrogenase activity; IEA:InterPro.
DR GO; GO:0006694; P:steroid biosynthetic process; IEA:InterPro.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR002225; 3Beta_OHSteriod_DH/Estase.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43245; BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA; 1.
DR PANTHER; PTHR43245:SF51; SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY 42E, MEMBER 2; 1.
DR Pfam; PF01073; 3Beta_HSD; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|RuleBase:RU004475};
KW Oxidoreductase {ECO:0000256|RuleBase:RU004475};
KW Reference proteome {ECO:0000313|Proteomes:UP000030746};
KW Transmembrane {ECO:0000256|RuleBase:RU004475};
KW Transmembrane helix {ECO:0000256|RuleBase:RU004475}.
FT TRANSMEM 258..277
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004475"
FT DOMAIN 4..255
FT /note="3-beta hydroxysteroid dehydrogenase/isomerase"
FT /evidence="ECO:0000259|Pfam:PF01073"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ESO89403.1"
SQ SEQUENCE 335 AA; 38069 MW; DD1699E79A9B1054 CRC64;
ERCLVIGGCG FLGRHLLEKL LERGYEVQAF DVRKSFDDDR IKVFVGDLCK KEELLPALQD
VDIVFHCATP APLSNNKALF YKVNYEGTKT IILACKEMKI KKFVLTSSAS VVYEGKDILN
GKEDLPYAKN PIDYYTETKI LQEKVVLGAN DDNFHSVAVR PHGIFGPRDP HMIPTSVEMA
RKGKTKFIIG QNIVDFTFVE NVVHGHILAA ESLHRDSVVC GKAYHITNDE PIYFWTFMTK
LLTSFGYDAP KYNLPYSLVY FIALLLQFVC WILSPLVEIK PTFTPMKVAL AGTHHYYDCS
RAKRDLKYKP LVSLDDAIER AVKSYPEMRK DAKPT
//
