ID V3ZMY8_LOTGI Unreviewed; 878 AA.
AC V3ZMY8;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE RecName: Full=NTR domain-containing protein {ECO:0000259|PROSITE:PS50189};
GN ORFNames=LOTGIDRAFT_169046 {ECO:0000313|EMBL:ESO83810.1};
OS Lottia gigantea (Giant owl limpet).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Patellogastropoda; Lottioidea; Lottiidae; Lottia.
OX NCBI_TaxID=225164 {ECO:0000313|EMBL:ESO83810.1, ECO:0000313|Proteomes:UP000030746};
RN [1] {ECO:0000313|EMBL:ESO83810.1, ECO:0000313|Proteomes:UP000030746}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
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DR EMBL; KB203598; ESO83810.1; -; Genomic_DNA.
DR RefSeq; XP_009065589.1; XM_009067341.1.
DR AlphaFoldDB; V3ZMY8; -.
DR STRING; 225164.V3ZMY8; -.
DR EnsemblMetazoa; LotgiT169046; LotgiP169046; LotgiG169046.
DR GeneID; 20241048; -.
DR KEGG; lgi:LOTGIDRAFT_169046; -.
DR CTD; 20241048; -.
DR HOGENOM; CLU_327694_0_0_1; -.
DR OMA; ISICARY; -.
DR OrthoDB; 4033541at2759; -.
DR Proteomes; UP000030746; Unassembled WGS sequence.
DR GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR CDD; cd02896; complement_C3_C4_C5; 1.
DR Gene3D; 1.50.10.20; -; 1.
DR Gene3D; 2.40.50.120; -; 1.
DR Gene3D; 2.60.120.1540; -; 1.
DR Gene3D; 2.60.40.690; Alpha-macroglobulin, receptor-binding domain; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR009048; A-macroglobulin_rcpt-bd.
DR InterPro; IPR036595; A-macroglobulin_rcpt-bd_sf.
DR InterPro; IPR047565; Alpha-macroglob_thiol-ester_cl.
DR InterPro; IPR011626; Alpha-macroglobulin_TED.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR019742; MacrogloblnA2_CS.
DR InterPro; IPR001134; Netrin_domain.
DR InterPro; IPR018933; Netrin_module_non-TIMP.
DR InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR InterPro; IPR008993; TIMP-like_OB-fold.
DR PANTHER; PTHR11412:SF136; ALPHA-2-MACROGLOBULIN HOMOLOG-RELATED; 1.
DR PANTHER; PTHR11412; MACROGLOBULIN / COMPLEMENT; 1.
DR Pfam; PF07677; A2M_recep; 1.
DR Pfam; PF01759; NTR; 1.
DR Pfam; PF07678; TED_complement; 1.
DR SMART; SM01361; A2M_recep; 1.
DR SMART; SM01419; Thiol-ester_cl; 1.
DR SUPFAM; SSF49410; Alpha-macroglobulin receptor domain; 1.
DR SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 1.
DR SUPFAM; SSF50242; TIMP-like; 1.
DR PROSITE; PS00477; ALPHA_2_MACROGLOBULIN; 1.
DR PROSITE; PS50189; NTR; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Reference proteome {ECO:0000313|Proteomes:UP000030746};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Thioester bond {ECO:0000256|ARBA:ARBA00022966}.
FT DOMAIN 714..862
FT /note="NTR"
FT /evidence="ECO:0000259|PROSITE:PS50189"
SQ SEQUENCE 878 AA; 100181 MW; 60F2E5B3F631C678 CRC64;
MAHVDIPPND AASVSFPIIP LELGLFPIRV YAYSTWGNDA VEKILYVEGE GLEKIHTVSV
MLDPSGKRLV RDKVNNVTFD LLNEVDEAGH KQKVHLDLDL PQNVVPETEK CTVSAIGVDT
LLKLPTGCGE QNLIHLAPNV YVMRYLKATG RLMPEVEKKA RVFMRQGMLR QLTFRKEDGS
FATWPHADSS TWLTAFALKV MTESKTFIAV DNNVTCKALT WLLNRHKTDG SFMEDSWVMH
KEMLGGTTGE TTLAAFVLIA ILESDCKPEG EYDVDESRLR TISYLESKLE ELDRPLAVAM
TTYALALAYS PSRHRANEIL RNIAERTPEG FIHWGAGDVE NFKIDLKPHW FNKEPNALAV
EATAYALLAQ LEMGEIQYSN QIVGWLLQQR ESHGSFVSTQ DTVIGLQALS EYSVRTYSAI
LDMTCHITSE ADQNFQRLIS LRHEDALVLK SVPQVPTGGK LMFEAAGTGV GMMQVEVRFN
VPQEGDACKF DVSVVSRRLS HMVYQFFSHN SRSDCEPCAE SCDDAEEEED EEDYETFTFP
SIIPRIQRID LDKDEGNVGS RIGRPFSRIG RPLSRFRRSV SARNLCVEVC VRYQGERETG
MSVLDVGLFT GYQPIDADLD AMKAKGKIQH YEKSQRSLIL YIEEISNKKT ECYKFRAKQK
HIVENIQPAK VQVFDYYNPT ERCTYFYKPD NVSGHLTNFC DDKKSICQCL EGRCSRCEDD
WYGKKWQEII KYACQNTTYV LQIKILDMQV ESTGFQRVLA VVQKVIYSDG MLKLQQKDKL
ILLKRSSCMC PYFTVGKIYT LMARDPKRFR DNDGNLVHAF LMDKMAVVTQ IYKSRQKNLS
GMQKQMARQF RRFQKRLLRK GCRNHRKKGR ILHSFPGK
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