ID   V3ZP82_LOTGI            Unreviewed;       639 AA.
AC   V3ZP82;
DT   22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT   22-JAN-2014, sequence version 1.
DT   27-MAR-2024, entry version 49.
DE   RecName: Full=HELP domain-containing protein {ECO:0008006|Google:ProtNLM};
DE   Flags: Fragment;
GN   ORFNames=LOTGIDRAFT_129615 {ECO:0000313|EMBL:ESO86147.1};
OS   Lottia gigantea (Giant owl limpet).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Patellogastropoda; Lottioidea; Lottiidae; Lottia.
OX   NCBI_TaxID=225164 {ECO:0000313|EMBL:ESO86147.1, ECO:0000313|Proteomes:UP000030746};
RN   [1] {ECO:0000313|EMBL:ESO86147.1, ECO:0000313|Proteomes:UP000030746}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23254933; DOI=10.1038/nature11696;
RA   Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA   Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA   Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA   Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA   Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT   "Insights into bilaterian evolution from three spiralian genomes.";
RL   Nature 493:526-531(2013).
CC   -!- SIMILARITY: Belongs to the WD repeat EMAP family.
CC       {ECO:0000256|ARBA:ARBA00006489}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; KB203149; ESO86147.1; -; Genomic_DNA.
DR   RefSeq; XP_009063108.1; XM_009064860.1.
DR   AlphaFoldDB; V3ZP82; -.
DR   STRING; 225164.V3ZP82; -.
DR   EnsemblMetazoa; LotgiT129615; LotgiP129615; LotgiG129615.
DR   GeneID; 20232978; -.
DR   KEGG; lgi:LOTGIDRAFT_129615; -.
DR   CTD; 20232978; -.
DR   HOGENOM; CLU_011754_2_0_1; -.
DR   OMA; ICCADFH; -.
DR   OrthoDB; 2959353at2759; -.
DR   Proteomes; UP000030746; Unassembled WGS sequence.
DR   Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR   InterPro; IPR005108; HELP.
DR   InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR   InterPro; IPR049040; RMC1_N.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR001680; WD40_rpt.
DR   PANTHER; PTHR13720:SF50; ECHINODERM MICROTUBULE-ASSOCIATED PROTEIN-LIKE 2; 1.
DR   PANTHER; PTHR13720; WD-40 REPEAT PROTEIN; 1.
DR   Pfam; PF03451; HELP; 1.
DR   Pfam; PF21029; RMC1_N; 1.
DR   Pfam; PF00400; WD40; 5.
DR   SMART; SM00320; WD40; 11.
DR   SUPFAM; SSF50998; Quinoprotein alcohol dehydrogenase-like; 1.
DR   SUPFAM; SSF50978; WD40 repeat-like; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 3.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000030746};
KW   WD repeat {ECO:0000256|PROSITE-ProRule:PRU00221}.
FT   DOMAIN          10..80
FT                   /note="HELP"
FT                   /evidence="ECO:0000259|Pfam:PF03451"
FT   REPEAT          361..402
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT   DOMAIN          424..508
FT                   /note="Regulator of MON1-CCZ1 complex N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF21029"
FT   REPEAT          444..485
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT   REPEAT          604..639
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:ESO86147.1"
SQ   SEQUENCE   639 AA;  70929 MW;  2AFD86CD1608EC49 CRC64;
     VLLLDEGYLK IYIKGRGIAL YAPSEVTDFD VSKVGDAPNE KLQLEWVYGY RGRDCRSNLY
     HLPTGEIIYF IAATVVLYNV EEGMQRHYTG HTDDVKCLAI HPDKVKIATG QVAGHDKKEG
     KPHVRIWDSV SLNTLMVVGL GDFDRAVCCV SFSKLDGGHQ LVCVDDANEH VISVWDVSRD
     KPHKITETKS STDPVLVTEF NPNENNQIVM CGKGQISFWT LESGTLNKKQ GIYEKLEKPK
     YVLCLAFAEN GDVLSGDSNG NIFVWGRGTN RITQAINGAH DGGVFSLCVM KDGTLLSGGG
     KDRKVYQFDE SYKRTGLETE IPEAYGPVRT LSQGHGNLIL VGTTRNSILQ GTLDLNFNPV
     VHGHIDELWG MACHPSQHQF MSCGSDKHIY LWDSMSHSVI WTKEITDPAH CCCFHPDGNI
     AVVGTHNARW LVIDLNTHDV ITAHTDGNEQ IECVQFSPDG KYLAVGSRDN YIYLYQVTDG
     GTKYTKTGRC SGHSSFITHV DWSEDGQYLV SNSGDYEVLY CKYWTTNCRQ VTSPDNVRNV
     QWATQSCTLG FNVAGIWPEG ADGTDVNCCA RTKNHTVIAS GDDFGKVNLY KYPCCSPRSS
     SHINKGHSSH VTSVNFLYDD SRMISAGGRD MAIMQWEII
//