ID V3ZQ74_LOTGI Unreviewed; 328 AA.
AC V3ZQ74;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE RecName: Full=Cathepsin L {ECO:0008006|Google:ProtNLM};
GN ORFNames=LOTGIDRAFT_189728 {ECO:0000313|EMBL:ESO93538.1};
OS Lottia gigantea (Giant owl limpet).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Patellogastropoda; Lottioidea; Lottiidae; Lottia.
OX NCBI_TaxID=225164 {ECO:0000313|EMBL:ESO93538.1, ECO:0000313|Proteomes:UP000030746};
RN [1] {ECO:0000313|EMBL:ESO93538.1, ECO:0000313|Proteomes:UP000030746}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
CC -!- SIMILARITY: Belongs to the peptidase C1 family.
CC {ECO:0000256|ARBA:ARBA00008455}.
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DR EMBL; KB201891; ESO93538.1; -; Genomic_DNA.
DR RefSeq; XP_009055738.1; XM_009057490.1.
DR AlphaFoldDB; V3ZQ74; -.
DR STRING; 225164.V3ZQ74; -.
DR EnsemblMetazoa; LotgiT189728; LotgiP189728; LotgiG189728.
DR GeneID; 20244856; -.
DR KEGG; lgi:LOTGIDRAFT_189728; -.
DR CTD; 20244856; -.
DR HOGENOM; CLU_012184_1_2_1; -.
DR OMA; CLHTFNA; -.
DR OrthoDB; 5472948at2759; -.
DR Proteomes; UP000030746; Unassembled WGS sequence.
DR GO; GO:0008234; F:cysteine-type peptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd02248; Peptidase_C1A; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR025661; Pept_asp_AS.
DR InterPro; IPR000169; Pept_cys_AS.
DR InterPro; IPR025660; Pept_his_AS.
DR InterPro; IPR013128; Peptidase_C1A.
DR InterPro; IPR000668; Peptidase_C1A_C.
DR InterPro; IPR039417; Peptidase_C1A_papain-like.
DR InterPro; IPR013201; Prot_inhib_I29.
DR PANTHER; PTHR12411; CYSTEINE PROTEASE FAMILY C1-RELATED; 1.
DR PANTHER; PTHR12411:SF1020; INHIBITOR_I29 DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF08246; Inhibitor_I29; 1.
DR Pfam; PF00112; Peptidase_C1; 1.
DR PRINTS; PR00705; PAPAIN.
DR SMART; SM00848; Inhibitor_I29; 1.
DR SMART; SM00645; Pept_C1; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR PROSITE; PS00640; THIOL_PROTEASE_ASN; 1.
DR PROSITE; PS00139; THIOL_PROTEASE_CYS; 1.
DR PROSITE; PS00639; THIOL_PROTEASE_HIS; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000030746};
KW Signal {ECO:0000256|SAM:SignalP};
KW Thiol protease {ECO:0000256|ARBA:ARBA00022807};
KW Zymogen {ECO:0000256|ARBA:ARBA00023145}.
FT SIGNAL 1..16
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 17..328
FT /note="Cathepsin L"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018626172"
FT DOMAIN 25..84
FT /note="Cathepsin propeptide inhibitor"
FT /evidence="ECO:0000259|SMART:SM00848"
FT DOMAIN 112..327
FT /note="Peptidase C1A papain C-terminal"
FT /evidence="ECO:0000259|SMART:SM00645"
SQ SEQUENCE 328 AA; 36744 MW; 55E2A1F6583F9725 CRC64;
MLKLVVLAVV CCVSLAIDTQ LDSAWKQYKQ QHGKLYNPVS DNMRRIVWES NLELIAQHNK
EADQGRHSYR LGMNAYGDMT NAEFNALMNG YRGEDYKPSG LKHESKTPVE ALPTEVDWRQ
KGFVTPIKDQ KQCGSCWSFS ATGSLEGQHF KRTGKLVSLS EQNLCDCSRK EGNMGCEGGL
MDQAFIYVKK NRGIDTEASY PYKAIDEKCH FKRKDVGANL TSHVDVKRES EEDLKKAVAE
VGPISVAIDA SHNSFQLYAS GVYDEPACSK IRLDHGVLAV GYGVHESKDY WLVKNSWGTT
WGMQGYIMMS RNKKNQCGIA TQASYPVV
//
