ID V3ZQK4_LOTGI Unreviewed; 445 AA.
AC V3ZQK4;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE RecName: Full=Mothers against decapentaplegic homolog {ECO:0000256|RuleBase:RU361195};
DE Short=MAD homolog {ECO:0000256|RuleBase:RU361195};
DE Short=Mothers against DPP homolog {ECO:0000256|RuleBase:RU361195};
DE AltName: Full=SMAD family member {ECO:0000256|RuleBase:RU361195};
GN ORFNames=LOTGIDRAFT_104873 {ECO:0000313|EMBL:ESO93683.1};
OS Lottia gigantea (Giant owl limpet).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Patellogastropoda; Lottioidea; Lottiidae; Lottia.
OX NCBI_TaxID=225164 {ECO:0000313|EMBL:ESO93683.1, ECO:0000313|Proteomes:UP000030746};
RN [1] {ECO:0000313|EMBL:ESO93683.1, ECO:0000313|Proteomes:UP000030746}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|RuleBase:RU361195}.
CC Nucleus {ECO:0000256|RuleBase:RU361195}.
CC -!- SIMILARITY: Belongs to the dwarfin/SMAD family.
CC {ECO:0000256|ARBA:ARBA00005545, ECO:0000256|RuleBase:RU361195}.
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DR EMBL; KB201890; ESO93683.1; -; Genomic_DNA.
DR RefSeq; XP_009055318.1; XM_009057070.1.
DR AlphaFoldDB; V3ZQK4; -.
DR STRING; 225164.V3ZQK4; -.
DR EnsemblMetazoa; LotgiT104873; LotgiP104873; LotgiG104873.
DR GeneID; 20229908; -.
DR KEGG; lgi:LOTGIDRAFT_104873; -.
DR CTD; 20229908; -.
DR HOGENOM; CLU_026736_0_2_1; -.
DR OMA; WASVAYY; -.
DR OrthoDB; 2891561at2759; -.
DR Proteomes; UP000030746; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005667; C:transcription regulator complex; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd10490; MH1_SMAD_1_5_9; 1.
DR CDD; cd10497; MH2_SMAD_1_5_9; 1.
DR Gene3D; 2.60.200.10; -; 1.
DR Gene3D; 3.90.520.10; SMAD MH1 domain; 1.
DR InterPro; IPR013790; Dwarfin.
DR InterPro; IPR003619; MAD_homology1_Dwarfin-type.
DR InterPro; IPR013019; MAD_homology_MH1.
DR InterPro; IPR017855; SMAD-like_dom_sf.
DR InterPro; IPR001132; SMAD_dom_Dwarfin-type.
DR InterPro; IPR008984; SMAD_FHA_dom_sf.
DR InterPro; IPR036578; SMAD_MH1_sf.
DR PANTHER; PTHR13703:SF61; PROTEIN MOTHERS AGAINST DPP; 1.
DR PANTHER; PTHR13703; SMAD; 1.
DR Pfam; PF03165; MH1; 1.
DR Pfam; PF03166; MH2; 1.
DR SMART; SM00523; DWA; 1.
DR SMART; SM00524; DWB; 1.
DR SUPFAM; SSF56366; SMAD MH1 domain; 1.
DR SUPFAM; SSF49879; SMAD/FHA domain; 1.
DR PROSITE; PS51075; MH1; 1.
DR PROSITE; PS51076; MH2; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|RuleBase:RU361195};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU361195};
KW Reference proteome {ECO:0000313|Proteomes:UP000030746};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU361195};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU361195}; Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 14..138
FT /note="MH1"
FT /evidence="ECO:0000259|PROSITE:PS51075"
FT DOMAIN 251..445
FT /note="MH2"
FT /evidence="ECO:0000259|PROSITE:PS51076"
FT REGION 171..223
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 445 AA; 50291 MW; 4DFC37FF1F8A0977 CRC64;
MTSPLSSIFS FTSPAVKRLL GWKQGDEEEK WAEKAVDSLV KKLKKTKGAL ENLEKALSQP
GQLSKCVTIP RSLDGRLQVS HRKGLPHVIY CRVWRWPDLQ SHHELKPLEC CEYPFSAKQK
DVCINPYHYK RVESPVLPPV LVPRYSEFPA HHGGPNHMPL LPFQQVPEPS MPHNVTYPFQ
QPQATPPQQQ PNSPQSSGPG SPYGLPADTP PPAYQPPEDN NQNNININQI MLENYFISDV
QPVTYQEPQY WCSIVYYELN NRVGEAFHAS RSSIVVDGFT DPSNNADRFC LGLLSNVNRN
STIENTRRHI SKGVHLYYVG GEVFAECLSD SSIFVQSRNC NYHHGFHPTT VCKIPPGCSL
KIFNNQEFAT LLSQSVNHGF EAVYELTKMC TIRMSFVKGW GAEYHRQDVT STPCWIELHL
NGPLQWLDKV LTQMGSPHNP ISSVS
//
