ID V3ZU63_LOTGI Unreviewed; 395 AA.
AC V3ZU63;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE RecName: Full=E2F/DP family winged-helix DNA-binding domain-containing protein {ECO:0000259|SMART:SM01372};
GN ORFNames=LOTGIDRAFT_127203 {ECO:0000313|EMBL:ESO87892.1};
OS Lottia gigantea (Giant owl limpet).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Patellogastropoda; Lottioidea; Lottiidae; Lottia.
OX NCBI_TaxID=225164 {ECO:0000313|EMBL:ESO87892.1, ECO:0000313|Proteomes:UP000030746};
RN [1] {ECO:0000313|EMBL:ESO87892.1, ECO:0000313|Proteomes:UP000030746}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU003796}.
CC -!- SIMILARITY: Belongs to the E2F/DP family.
CC {ECO:0000256|ARBA:ARBA00010940, ECO:0000256|RuleBase:RU003796}.
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DR EMBL; KB202823; ESO87892.1; -; Genomic_DNA.
DR RefSeq; XP_009061493.1; XM_009063245.1.
DR AlphaFoldDB; V3ZU63; -.
DR STRING; 225164.V3ZU63; -.
DR EnsemblMetazoa; LotgiT127203; LotgiP127203; LotgiG127203.
DR GeneID; 20232685; -.
DR KEGG; lgi:LOTGIDRAFT_127203; -.
DR CTD; 20232685; -.
DR HOGENOM; CLU_032091_2_0_1; -.
DR OMA; THEDTCK; -.
DR OrthoDB; 1761at2759; -.
DR Proteomes; UP000030746; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005667; C:transcription regulator complex; IEA:InterPro.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR CDD; cd14660; E2F_DD; 1.
DR Gene3D; 6.10.250.540; -; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR015633; E2F.
DR InterPro; IPR037241; E2F-DP_heterodim.
DR InterPro; IPR032198; E2F_CC-MB.
DR InterPro; IPR003316; E2F_WHTH_DNA-bd_dom.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR12081; TRANSCRIPTION FACTOR E2F; 1.
DR PANTHER; PTHR12081:SF18; TRANSCRIPTION FACTOR E2F2; 1.
DR Pfam; PF16421; E2F_CC-MB; 1.
DR Pfam; PF02319; E2F_TDP; 1.
DR SMART; SM01372; E2F_TDP; 1.
DR SUPFAM; SSF144074; E2F-DP heterodimerization region; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU003796};
KW Nucleus {ECO:0000256|RuleBase:RU003796};
KW Reference proteome {ECO:0000313|Proteomes:UP000030746};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU003796};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU003796}.
FT DOMAIN 9..75
FT /note="E2F/DP family winged-helix DNA-binding"
FT /evidence="ECO:0000259|SMART:SM01372"
FT REGION 198..271
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 212..248
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 257..271
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 395 AA; 43631 MW; D102DA85DFD7FB9B CRC64;
MADQITPSRH EKSLGLLTTK FVSLLQEAKD GVLDLKVAAD QLAVRQKRRI YDITNVLEGI
GLIEKKSKNS IQWKGAGPGC NTREISDKLM TLKTDLAELT KREEEIDQHK MWVQQSIKNV
TDEVTNTRLA YVTHEDTCKC FSGDTLIAVQ APSGTQLEVP IPEIGADFKK NYQIHLKSHS
GAINVLLVNK DTEASSPVVV QVPPPVDDLI NKSENENPNP TSKSTRGAAK KTGPKSPLKT
TQQPASLDIF PVTRMATRSS PRKNNDSFQG KNSKLNFSPV FYIEDIKNCP LCTMHGVIMS
SLYFSATSSL SSRHSPSLPG LDPFSSDLPL LDPTRADMLG KYLIGFFTEC SNSSFFSAFA
PLLRLSPVPN DRDYYFNLDD SEGVCDLFDV PLISM
//
