ID   V3ZWW2_LOTGI            Unreviewed;       645 AA.
AC   V3ZWW2;
DT   22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT   22-JAN-2014, sequence version 1.
DT   24-JAN-2024, entry version 38.
DE   RecName: Full=Peptidase M4 C-terminal domain-containing protein {ECO:0008006|Google:ProtNLM};
GN   ORFNames=LOTGIDRAFT_154924 {ECO:0000313|EMBL:ESO85431.1};
OS   Lottia gigantea (Giant owl limpet).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Patellogastropoda; Lottioidea; Lottiidae; Lottia.
OX   NCBI_TaxID=225164 {ECO:0000313|EMBL:ESO85431.1, ECO:0000313|Proteomes:UP000030746};
RN   [1] {ECO:0000313|EMBL:ESO85431.1, ECO:0000313|Proteomes:UP000030746}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23254933; DOI=10.1038/nature11696;
RA   Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA   Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA   Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA   Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA   Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT   "Insights into bilaterian evolution from three spiralian genomes.";
RL   Nature 493:526-531(2013).
CC   -!- SIMILARITY: Belongs to the peptidase M4 family.
CC       {ECO:0000256|ARBA:ARBA00009388}.
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DR   EMBL; KB203274; ESO85431.1; -; Genomic_DNA.
DR   RefSeq; XP_009063677.1; XM_009065429.1.
DR   AlphaFoldDB; V3ZWW2; -.
DR   STRING; 225164.V3ZWW2; -.
DR   EnsemblMetazoa; LotgiT154924; LotgiP154924; LotgiG154924.
DR   GeneID; 20236450; -.
DR   KEGG; lgi:LOTGIDRAFT_154924; -.
DR   CTD; 20236450; -.
DR   HOGENOM; CLU_008590_4_2_1; -.
DR   OMA; MDIVAHE; -.
DR   OrthoDB; 2679274at2759; -.
DR   Proteomes; UP000030746; Unassembled WGS sequence.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   CDD; cd09597; M4_TLP; 1.
DR   Gene3D; 3.10.170.10; -; 1.
DR   Gene3D; 3.10.450.40; -; 1.
DR   Gene3D; 1.10.390.10; Neutral Protease Domain 2; 1.
DR   InterPro; IPR011096; FTP_domain.
DR   InterPro; IPR023612; Peptidase_M4.
DR   InterPro; IPR027268; Peptidase_M4/M1_CTD_sf.
DR   InterPro; IPR001570; Peptidase_M4_C_domain.
DR   InterPro; IPR013856; Peptidase_M4_domain.
DR   PANTHER; PTHR33794; BACILLOLYSIN; 1.
DR   PANTHER; PTHR33794:SF1; BACILLOLYSIN; 1.
DR   Pfam; PF07504; FTP; 1.
DR   Pfam; PF01447; Peptidase_M4; 1.
DR   Pfam; PF02868; Peptidase_M4_C; 1.
DR   PRINTS; PR00730; THERMOLYSIN.
DR   SUPFAM; SSF55486; Metalloproteases ('zincins'), catalytic domain; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW   Protease {ECO:0000256|ARBA:ARBA00022670};
KW   Reference proteome {ECO:0000313|Proteomes:UP000030746};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           20..645
FT                   /note="Peptidase M4 C-terminal domain-containing protein"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5004716366"
FT   DOMAIN          64..110
FT                   /note="FTP"
FT                   /evidence="ECO:0000259|Pfam:PF07504"
FT   DOMAIN          230..357
FT                   /note="Peptidase M4"
FT                   /evidence="ECO:0000259|Pfam:PF01447"
FT   DOMAIN          360..503
FT                   /note="Peptidase M4 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF02868"
SQ   SEQUENCE   645 AA;  74807 MW;  B7B0526047977E1C CRC64;
     MELFVLTLWF GILIVSTEAA IKVDPRTRLR RCFSNSFRNR RRSVEDDKPI SLREVLDFEK
     KLDFSPQNIF KSSQGNTIIK FKETVNGKNV FDGEVTAMLD KNGVGIDVSG LFFEDINAKE
     LNDQRKISIT EAFKLAKQIH GHTGEKIHRF SHELDIFIGN DSISHLAYFI DYFVVVQNIP
     QRPITVVDSK DGKILLKFNN LETCKYSKTI YGGNRKLGRI PYSHFFNCQN VDREGNMCSL
     ENEFVRVIDM NSTVNDSITE SATFRCNETY IDSVNGAYSP AFDAFFYGTT IARMLHEWYD
     VTPKRRPLLL RVHYSKNLTD AFWDGRYCSF GDSEKNKFYP MVSMDIVAHE IGHSITEQYS
     NLLYMGESGG INEAFSDMMG ETAEYYVGML DWMVGYYVTR QQKALRYFDD PTMDNRSITH
     IRDYYEGMDT HSSSGIFRKV FYDLVKRHHI PIKKVFQVFL HANQIYWHKM SSFVSAACDV
     MKAALDLGTW VNRFAKAFRQ VGIEGCNVEE HIFWLRSDEV YSDIYVSEDT KPLFGFSAPP
     WARKILIETM GDVTIDITLY HAGLLSEEYY ILKSDINFLE YDINGSEGSH YFIQLGSSQE
     EVTLGVRIRV RYECVEVYKT EDILNYLNYQ KDCKKGRFFV SQKLF
//