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Database: UniProt
Entry: V3ZXT7_LOTGI
LinkDB: V3ZXT7_LOTGI
Original site: V3ZXT7_LOTGI 
ID   V3ZXT7_LOTGI            Unreviewed;       713 AA.
AC   V3ZXT7;
DT   22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT   22-JAN-2014, sequence version 1.
DT   24-JAN-2024, entry version 55.
DE   RecName: Full=TIR domain-containing protein {ECO:0000259|PROSITE:PS50104};
GN   ORFNames=LOTGIDRAFT_167776 {ECO:0000313|EMBL:ESO85801.1};
OS   Lottia gigantea (Giant owl limpet).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Patellogastropoda; Lottioidea; Lottiidae; Lottia.
OX   NCBI_TaxID=225164 {ECO:0000313|EMBL:ESO85801.1, ECO:0000313|Proteomes:UP000030746};
RN   [1] {ECO:0000313|EMBL:ESO85801.1, ECO:0000313|Proteomes:UP000030746}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23254933; DOI=10.1038/nature11696;
RA   Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA   Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA   Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA   Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA   Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT   "Insights into bilaterian evolution from three spiralian genomes.";
RL   Nature 493:526-531(2013).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC       pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC   -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC       {ECO:0000256|ARBA:ARBA00009634}.
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DR   EMBL; KB203251; ESO85801.1; -; Genomic_DNA.
DR   RefSeq; XP_009063532.1; XM_009065284.1.
DR   AlphaFoldDB; V3ZXT7; -.
DR   STRING; 225164.V3ZXT7; -.
DR   EnsemblMetazoa; LotgiT167776; LotgiP167776; LotgiG167776.
DR   GeneID; 20240693; -.
DR   KEGG; lgi:LOTGIDRAFT_167776; -.
DR   CTD; 20240693; -.
DR   HOGENOM; CLU_387474_0_0_1; -.
DR   OMA; ANDCRID; -.
DR   OrthoDB; 2958469at2759; -.
DR   Proteomes; UP000030746; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 3.
DR   Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR   InterPro; IPR000483; Cys-rich_flank_reg_C.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR000157; TIR_dom.
DR   InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR   PANTHER; PTHR24373:SF370; GH01279P-RELATED; 1.
DR   PANTHER; PTHR24373; SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN; 1.
DR   Pfam; PF13855; LRR_8; 1.
DR   Pfam; PF01582; TIR; 1.
DR   SMART; SM00364; LRR_BAC; 3.
DR   SMART; SM00369; LRR_TYP; 4.
DR   SMART; SM00082; LRRCT; 2.
DR   SMART; SM00255; TIR; 1.
DR   SUPFAM; SSF52058; L domain-like; 2.
DR   SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR   PROSITE; PS50104; TIR; 1.
PE   3: Inferred from homology;
KW   Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000030746};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           22..713
FT                   /note="TIR domain-containing protein"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5004716186"
FT   TRANSMEM        505..527
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          560..713
FT                   /note="TIR"
FT                   /evidence="ECO:0000259|PROSITE:PS50104"
SQ   SEQUENCE   713 AA;  83316 MW;  260B2B177215035B CRC64;
     MTSLCTLSLT VFFCCFYQID TSCVYDDYTD ILVNDVTKLK SIVESNRIYL DLSNRNLTDI
     KDISRMIKES GVGHTIIKLD ISYNNIENLP SDIFQHLPQV RSLNISNNNL TSLHPDTFIH
     NYCLRTLDIS YNNLENLPSG LLGSKDISLL GLTFFDVSHN KIKTMGYELF YEGLNSLRHV
     NISYNKLEYF EPWPYSTNQT ISKPIDGYVF NFSHNNIRDF SNKMKYYVGH EQPFSVDLNF
     NNLSRLRMDS FKVLFKPSND FTEYNLAHLN IDIRYNPWIC DCEMYPFVRS FVDSFLRTHP
     LLAGINCASP PLLAGKSFTY LVDNPQVLVC NITYNCPDRC FCEDRPDDRL ILIDCSHTNQ
     LTMPLNLPRV SKCSPNSRVN LMMDLSHNKI NNIIWTNYTQ NIIYLNISNN VIDKIESKFL
     KHAHSNLSLD IGNNMFKSLP NAIQNIHYNN LYFDNNPLEC NCDFLWFNDW IRLHAKHNNY
     TCTIKNDKHY IKDVTYNSLH CYTDLAILLC SILIPIFAIV VFAVLVYHKW IYETKVILSH
     ILEIASKSHT NLDKSEKALY KYDVYISSNV ESTDTRLWIR DNLLKKLDKY GLKVYYPPRN
     NPANDCRIDV MVENIATSRK ILIILDESYL HGGWCIEEFD QAHQNMCEEN KRKIIVFLCS
     NNINLDDIQQ ESLKTYIKHE QLIKRDDFLC WSKLRYEISN KCDEDKKVKV IHA
//
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