ID V3ZXT7_LOTGI Unreviewed; 713 AA.
AC V3ZXT7;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 24-JAN-2024, entry version 55.
DE RecName: Full=TIR domain-containing protein {ECO:0000259|PROSITE:PS50104};
GN ORFNames=LOTGIDRAFT_167776 {ECO:0000313|EMBL:ESO85801.1};
OS Lottia gigantea (Giant owl limpet).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Patellogastropoda; Lottioidea; Lottiidae; Lottia.
OX NCBI_TaxID=225164 {ECO:0000313|EMBL:ESO85801.1, ECO:0000313|Proteomes:UP000030746};
RN [1] {ECO:0000313|EMBL:ESO85801.1, ECO:0000313|Proteomes:UP000030746}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC {ECO:0000256|ARBA:ARBA00009634}.
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DR EMBL; KB203251; ESO85801.1; -; Genomic_DNA.
DR RefSeq; XP_009063532.1; XM_009065284.1.
DR AlphaFoldDB; V3ZXT7; -.
DR STRING; 225164.V3ZXT7; -.
DR EnsemblMetazoa; LotgiT167776; LotgiP167776; LotgiG167776.
DR GeneID; 20240693; -.
DR KEGG; lgi:LOTGIDRAFT_167776; -.
DR CTD; 20240693; -.
DR HOGENOM; CLU_387474_0_0_1; -.
DR OMA; ANDCRID; -.
DR OrthoDB; 2958469at2759; -.
DR Proteomes; UP000030746; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 3.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR24373:SF370; GH01279P-RELATED; 1.
DR PANTHER; PTHR24373; SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN; 1.
DR Pfam; PF13855; LRR_8; 1.
DR Pfam; PF01582; TIR; 1.
DR SMART; SM00364; LRR_BAC; 3.
DR SMART; SM00369; LRR_TYP; 4.
DR SMART; SM00082; LRRCT; 2.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 2.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS50104; TIR; 1.
PE 3: Inferred from homology;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000030746};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..713
FT /note="TIR domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004716186"
FT TRANSMEM 505..527
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 560..713
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
SQ SEQUENCE 713 AA; 83316 MW; 260B2B177215035B CRC64;
MTSLCTLSLT VFFCCFYQID TSCVYDDYTD ILVNDVTKLK SIVESNRIYL DLSNRNLTDI
KDISRMIKES GVGHTIIKLD ISYNNIENLP SDIFQHLPQV RSLNISNNNL TSLHPDTFIH
NYCLRTLDIS YNNLENLPSG LLGSKDISLL GLTFFDVSHN KIKTMGYELF YEGLNSLRHV
NISYNKLEYF EPWPYSTNQT ISKPIDGYVF NFSHNNIRDF SNKMKYYVGH EQPFSVDLNF
NNLSRLRMDS FKVLFKPSND FTEYNLAHLN IDIRYNPWIC DCEMYPFVRS FVDSFLRTHP
LLAGINCASP PLLAGKSFTY LVDNPQVLVC NITYNCPDRC FCEDRPDDRL ILIDCSHTNQ
LTMPLNLPRV SKCSPNSRVN LMMDLSHNKI NNIIWTNYTQ NIIYLNISNN VIDKIESKFL
KHAHSNLSLD IGNNMFKSLP NAIQNIHYNN LYFDNNPLEC NCDFLWFNDW IRLHAKHNNY
TCTIKNDKHY IKDVTYNSLH CYTDLAILLC SILIPIFAIV VFAVLVYHKW IYETKVILSH
ILEIASKSHT NLDKSEKALY KYDVYISSNV ESTDTRLWIR DNLLKKLDKY GLKVYYPPRN
NPANDCRIDV MVENIATSRK ILIILDESYL HGGWCIEEFD QAHQNMCEEN KRKIIVFLCS
NNINLDDIQQ ESLKTYIKHE QLIKRDDFLC WSKLRYEISN KCDEDKKVKV IHA
//