ID V3ZY22_LOTGI Unreviewed; 413 AA.
AC V3ZY22;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=ceramide glucosyltransferase {ECO:0000256|ARBA:ARBA00012699};
DE EC=2.4.1.80 {ECO:0000256|ARBA:ARBA00012699};
GN ORFNames=LOTGIDRAFT_235024 {ECO:0000313|EMBL:ESO87535.1};
OS Lottia gigantea (Giant owl limpet).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Patellogastropoda; Lottioidea; Lottiidae; Lottia.
OX NCBI_TaxID=225164 {ECO:0000313|EMBL:ESO87535.1, ECO:0000313|Proteomes:UP000030746};
RN [1] {ECO:0000313|EMBL:ESO87535.1, ECO:0000313|Proteomes:UP000030746}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
CC -!- PATHWAY: Lipid metabolism; sphingolipid metabolism.
CC {ECO:0000256|ARBA:ARBA00004760}.
CC -!- PATHWAY: Sphingolipid metabolism. {ECO:0000256|ARBA:ARBA00004991}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 2 family.
CC {ECO:0000256|ARBA:ARBA00006739}.
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DR EMBL; KB202883; ESO87535.1; -; Genomic_DNA.
DR RefSeq; XP_009061731.1; XM_009063483.1.
DR AlphaFoldDB; V3ZY22; -.
DR STRING; 225164.V3ZY22; -.
DR EnsemblMetazoa; LotgiT235024; LotgiP235024; LotgiG235024.
DR GeneID; 20249726; -.
DR KEGG; lgi:LOTGIDRAFT_235024; -.
DR CTD; 20249726; -.
DR HOGENOM; CLU_030898_1_0_1; -.
DR OMA; DIAMITT; -.
DR OrthoDB; 2950638at2759; -.
DR UniPathway; UPA00222; -.
DR Proteomes; UP000030746; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008120; F:ceramide glucosyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0102769; F:dihydroceramide glucosyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0006665; P:sphingolipid metabolic process; IEA:UniProtKB-UniPathway.
DR CDD; cd02520; Glucosylceramide_synthase; 1.
DR InterPro; IPR025993; Ceramide_glucosylTrfase.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR PANTHER; PTHR12726; CERAMIDE GLUCOSYLTRANSFERASE; 1.
DR PANTHER; PTHR12726:SF0; CERAMIDE GLUCOSYLTRANSFERASE; 1.
DR Pfam; PF13506; Glyco_transf_21; 1.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
PE 3: Inferred from homology;
KW Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000030746};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..38
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 293..315
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 321..341
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 413 AA; 47334 MW; D2F81DEE6E2F5984 CRC64;
MIYFEPQTWS NITLIFGILA LVLYCLSTFM IFLSLVYAKC KLHKKSAFRP NILYNGNPNG
NQGVSVIKPL LGTDPLLRIN LESHFQLDYP KFELLFCFHD ENDPAVTLVN ELRECYPHVS
TRLFFGGCDG IVNPMVNNIL PAYNAASYGY IWISTSRIMA STEILLDMVE KLADPKVGLV
HQLPFVTDQP GLAGMLEKVY FGCVVSRYYL SINALGLLCA TGMSYTFRKS IVDEINGLEY
FGQYLAEDFF LTSKVFQAGY HLIVSAYPAQ QNVANPTISK FSDRIIRWLR LRLTMMTFTT
LLIEPAVECL VLGAYSAFFL HYYFGFNPYL FFIGHVTLWI IRDYIQLSIV QNAKLPFSKL
TFVLVWFLRE FLQIVMLMKA IMQPRTIKWG NRTYLVHFGG VTEIKREKSS MTT
//
