ID V4A048_LOTGI Unreviewed; 529 AA.
AC V4A048;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 24-JAN-2024, entry version 34.
DE RecName: Full=Lysosomal cobalamin transporter {ECO:0008006|Google:ProtNLM};
GN ORFNames=LOTGIDRAFT_235253 {ECO:0000313|EMBL:ESO86626.1};
OS Lottia gigantea (Giant owl limpet).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Patellogastropoda; Lottioidea; Lottiidae; Lottia.
OX NCBI_TaxID=225164 {ECO:0000313|EMBL:ESO86626.1, ECO:0000313|Proteomes:UP000030746};
RN [1] {ECO:0000313|EMBL:ESO86626.1, ECO:0000313|Proteomes:UP000030746}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
CC -!- SUBCELLULAR LOCATION: Lysosome membrane
CC {ECO:0000256|ARBA:ARBA00004155}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004155}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the LIMR family. LMBRD1 subfamily.
CC {ECO:0000256|ARBA:ARBA00009901}.
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DR EMBL; KB203019; ESO86626.1; -; Genomic_DNA.
DR RefSeq; XP_009062609.1; XM_009064361.1.
DR AlphaFoldDB; V4A048; -.
DR STRING; 225164.V4A048; -.
DR EnsemblMetazoa; LotgiT235253; LotgiP235253; LotgiG235253.
DR GeneID; 20249794; -.
DR KEGG; lgi:LOTGIDRAFT_235253; -.
DR CTD; 20249794; -.
DR HOGENOM; CLU_028341_1_0_1; -.
DR OMA; FWAQFVF; -.
DR OrthoDB; 8533at2759; -.
DR Proteomes; UP000030746; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR InterPro; IPR006876; LMBR1-like_membr_prot.
DR PANTHER; PTHR16130:SF2; LYSOSOMAL COBALAMIN TRANSPORT ESCORT PROTEIN LMBD1; 1.
DR PANTHER; PTHR16130; LYSOSOMAL COBALAMIN TRANSPORTER-RELATED; 1.
DR Pfam; PF04791; LMBR1; 1.
PE 3: Inferred from homology;
KW Cobalamin {ECO:0000256|ARBA:ARBA00022628};
KW Cobalt {ECO:0000256|ARBA:ARBA00023285};
KW Lysosome {ECO:0000256|ARBA:ARBA00023228};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000030746};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 12..33
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 45..71
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 96..120
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 140..158
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 189..211
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 303..322
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 364..386
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 407..426
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 481..503
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 529 AA; 60136 MW; 00842CE33F364A90 CRC64;
MAIPSFVLAA SWIPFVVILV LILLFSIGYV RYYMSKYDSE VSSTLAAIFA LAVGLFTTAL
IPVDIFLVSY MKDSDGEFKD WANDSTVRTE IEHSVLYAYL TLYGLVSFCI FILLPFMYFF
YEEKDEDSTC KSRCCTALKY LCVFIIFAAV LFCIGAFVPT KTLPNKNDTE WKQIEALIEE
MGSNGGEDAI SFTISVLSLI GMLLLILYTA YGMSSLPIGL IVGRLNVKKE RLEVQSQITD
TEGQIDSIKQ RHVGRKKMSK KDERRVEKLQ ESDHLMERRL RHLIEKENSC VNKCMKVLRP
FEMIFGILFG LLAVLIYFSL LLSNIDKAVH SKGYSIGYAL PQRTLPNPID IALVYSQKVF
PLDYILMSCI VVYFVFCSMS GIRNIGIWFF CVKMYKIRVR RTKPQGLLML CMILMFIILA
INIILYELTP QYSSFGSQHY KLNSTNEIKA CTTAVSSDNC TVTQMVTLLT SFFYKMNFFG
AAYYFGTWAF LGVYLIGLII AIIRGRKSAI STEVEDSDFE ESDEELLTG
//