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Database: UniProt
Entry: V4A048_LOTGI
LinkDB: V4A048_LOTGI
Original site: V4A048_LOTGI 
ID   V4A048_LOTGI            Unreviewed;       529 AA.
AC   V4A048;
DT   22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT   22-JAN-2014, sequence version 1.
DT   24-JAN-2024, entry version 34.
DE   RecName: Full=Lysosomal cobalamin transporter {ECO:0008006|Google:ProtNLM};
GN   ORFNames=LOTGIDRAFT_235253 {ECO:0000313|EMBL:ESO86626.1};
OS   Lottia gigantea (Giant owl limpet).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Patellogastropoda; Lottioidea; Lottiidae; Lottia.
OX   NCBI_TaxID=225164 {ECO:0000313|EMBL:ESO86626.1, ECO:0000313|Proteomes:UP000030746};
RN   [1] {ECO:0000313|EMBL:ESO86626.1, ECO:0000313|Proteomes:UP000030746}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23254933; DOI=10.1038/nature11696;
RA   Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA   Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA   Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA   Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA   Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT   "Insights into bilaterian evolution from three spiralian genomes.";
RL   Nature 493:526-531(2013).
CC   -!- SUBCELLULAR LOCATION: Lysosome membrane
CC       {ECO:0000256|ARBA:ARBA00004155}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004155}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the LIMR family. LMBRD1 subfamily.
CC       {ECO:0000256|ARBA:ARBA00009901}.
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DR   EMBL; KB203019; ESO86626.1; -; Genomic_DNA.
DR   RefSeq; XP_009062609.1; XM_009064361.1.
DR   AlphaFoldDB; V4A048; -.
DR   STRING; 225164.V4A048; -.
DR   EnsemblMetazoa; LotgiT235253; LotgiP235253; LotgiG235253.
DR   GeneID; 20249794; -.
DR   KEGG; lgi:LOTGIDRAFT_235253; -.
DR   CTD; 20249794; -.
DR   HOGENOM; CLU_028341_1_0_1; -.
DR   OMA; FWAQFVF; -.
DR   OrthoDB; 8533at2759; -.
DR   Proteomes; UP000030746; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR006876; LMBR1-like_membr_prot.
DR   PANTHER; PTHR16130:SF2; LYSOSOMAL COBALAMIN TRANSPORT ESCORT PROTEIN LMBD1; 1.
DR   PANTHER; PTHR16130; LYSOSOMAL COBALAMIN TRANSPORTER-RELATED; 1.
DR   Pfam; PF04791; LMBR1; 1.
PE   3: Inferred from homology;
KW   Cobalamin {ECO:0000256|ARBA:ARBA00022628};
KW   Cobalt {ECO:0000256|ARBA:ARBA00023285};
KW   Lysosome {ECO:0000256|ARBA:ARBA00023228};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000030746};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   TRANSMEM        12..33
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        45..71
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        96..120
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        140..158
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        189..211
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        303..322
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        364..386
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        407..426
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        481..503
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   529 AA;  60136 MW;  00842CE33F364A90 CRC64;
     MAIPSFVLAA SWIPFVVILV LILLFSIGYV RYYMSKYDSE VSSTLAAIFA LAVGLFTTAL
     IPVDIFLVSY MKDSDGEFKD WANDSTVRTE IEHSVLYAYL TLYGLVSFCI FILLPFMYFF
     YEEKDEDSTC KSRCCTALKY LCVFIIFAAV LFCIGAFVPT KTLPNKNDTE WKQIEALIEE
     MGSNGGEDAI SFTISVLSLI GMLLLILYTA YGMSSLPIGL IVGRLNVKKE RLEVQSQITD
     TEGQIDSIKQ RHVGRKKMSK KDERRVEKLQ ESDHLMERRL RHLIEKENSC VNKCMKVLRP
     FEMIFGILFG LLAVLIYFSL LLSNIDKAVH SKGYSIGYAL PQRTLPNPID IALVYSQKVF
     PLDYILMSCI VVYFVFCSMS GIRNIGIWFF CVKMYKIRVR RTKPQGLLML CMILMFIILA
     INIILYELTP QYSSFGSQHY KLNSTNEIKA CTTAVSSDNC TVTQMVTLLT SFFYKMNFFG
     AAYYFGTWAF LGVYLIGLII AIIRGRKSAI STEVEDSDFE ESDEELLTG
//
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