ID V4A281_LOTGI Unreviewed; 514 AA.
AC V4A281;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE RecName: Full=SEC7 domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=LOTGIDRAFT_209989 {ECO:0000313|EMBL:ESO89040.1};
OS Lottia gigantea (Giant owl limpet).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Patellogastropoda; Lottioidea; Lottiidae; Lottia.
OX NCBI_TaxID=225164 {ECO:0000313|EMBL:ESO89040.1, ECO:0000313|Proteomes:UP000030746};
RN [1] {ECO:0000313|EMBL:ESO89040.1, ECO:0000313|Proteomes:UP000030746}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
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DR EMBL; KB202619; ESO89040.1; -; Genomic_DNA.
DR RefSeq; XP_009060086.1; XM_009061838.1.
DR AlphaFoldDB; V4A281; -.
DR STRING; 225164.V4A281; -.
DR EnsemblMetazoa; LotgiT209989; LotgiP209989; LotgiG209989.
DR GeneID; 20246183; -.
DR KEGG; lgi:LOTGIDRAFT_209989; -.
DR CTD; 20246183; -.
DR HOGENOM; CLU_011021_1_1_1; -.
DR OMA; YIQVRPP; -.
DR OrthoDB; 204547at2759; -.
DR Proteomes; UP000030746; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0005543; F:phospholipid binding; IEA:InterPro.
DR GO; GO:0032012; P:regulation of ARF protein signal transduction; IEA:InterPro.
DR CDD; cd13295; PH_EFA6; 1.
DR CDD; cd00171; Sec7; 1.
DR Gene3D; 1.10.1000.11; Arf Nucleotide-binding Site Opener,domain 2; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR041681; PH_9.
DR InterPro; IPR001605; PH_dom-spectrin-type.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR023394; Sec7_C_sf.
DR InterPro; IPR000904; Sec7_dom.
DR InterPro; IPR035999; Sec7_dom_sf.
DR PANTHER; PTHR10663; GUANYL-NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR10663:SF376; PH AND SEC7 DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF15410; PH_9; 1.
DR Pfam; PF01369; Sec7; 1.
DR PRINTS; PR00683; SPECTRINPH.
DR SMART; SM00233; PH; 1.
DR SMART; SM00222; Sec7; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF48425; Sec7 domain; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50190; SEC7; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000030746}.
FT DOMAIN 50..217
FT /note="SEC7"
FT /evidence="ECO:0000259|PROSITE:PS50190"
FT DOMAIN 246..359
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT COILED 387..414
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 514 AA; 58663 MW; 4D06EEAAFA241D74 CRC64;
MSGTELNSNL NSVSEKTVLS SLAGVQSNVL PKHQANVDSS VDSNLDLSGL SEADSIYHQP
LKSVDRPSAS RLAKRLYALD GFRKSDVSRH LFKKNEFSNL VAEEYLKNFE FTGDTLDVSL
RKFLKQFCLT GETQERERVL AHFSHRYMEC NPGTFNSEDA CHTLTCAMML LNTDLHGQTV
GRKMTCSEFI ENLADLNDGE NFPKDILKTV FNSIKGEQLE WAMVSVPQQF IGQNPFLDVP
DPSKTIEYKK GYVMRKCCMD ADGRRTGLGK RSWKMFYAVL RDLILYLYKD EHQYKKGNLV
EVASNAIRVH HCLVTKATDY TKKQHVFRLQ SAEWAEFLFQ TSNSKELQEW MDTLNFVAAA
FSAEPLPGAL GSKTGFQRPL LPVSYTRKTL REQFKNHEEK VESLEQELHQ HRAGAPEKGA
KSRDIQDYLA KETYLDFELK RYKTYVLLLQ SKITALPEME SSLVETTIGE DDEVTSTTQF
NSPTNKPVQR SLSDRYSYRA AIYQTDPRVD YDLV
//
