ID V4A297_LOTGI Unreviewed; 3505 AA.
AC V4A297;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 08-NOV-2023, entry version 54.
DE RecName: Full=WD repeat and FYVE domain-containing protein 3 {ECO:0008006|Google:ProtNLM};
GN ORFNames=LOTGIDRAFT_154132 {ECO:0000313|EMBL:ESO89055.1};
OS Lottia gigantea (Giant owl limpet).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Patellogastropoda; Lottioidea; Lottiidae; Lottia.
OX NCBI_TaxID=225164 {ECO:0000313|EMBL:ESO89055.1, ECO:0000313|Proteomes:UP000030746};
RN [1] {ECO:0000313|EMBL:ESO89055.1, ECO:0000313|Proteomes:UP000030746}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KB202619; ESO89055.1; -; Genomic_DNA.
DR RefSeq; XP_009060099.1; XM_009061851.1.
DR STRING; 225164.V4A297; -.
DR EnsemblMetazoa; LotgiT154132; LotgiP154132; LotgiG154132.
DR GeneID; 20236220; -.
DR KEGG; lgi:LOTGIDRAFT_154132; -.
DR CTD; 20236220; -.
DR HOGENOM; CLU_000175_5_0_1; -.
DR OMA; GVCHLIE; -.
DR OrthoDB; 47483at2759; -.
DR Proteomes; UP000030746; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd06071; Beach; 1.
DR CDD; cd15719; FYVE_WDFY3; 1.
DR CDD; cd01201; PH_BEACH; 1.
DR Gene3D; 1.10.1540.10; BEACH domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR000409; BEACH_dom.
DR InterPro; IPR036372; BEACH_dom_sf.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR023362; PH-BEACH_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR InterPro; IPR000306; Znf_FYVE.
DR InterPro; IPR017455; Znf_FYVE-rel.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR46108; BLUE CHEESE; 1.
DR PANTHER; PTHR46108:SF4; BLUE CHEESE; 1.
DR Pfam; PF02138; Beach; 1.
DR Pfam; PF01363; FYVE; 1.
DR Pfam; PF14844; PH_BEACH; 1.
DR Pfam; PF00400; WD40; 2.
DR SMART; SM01026; Beach; 1.
DR SMART; SM00064; FYVE; 1.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF81837; BEACH domain; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50197; BEACH; 1.
DR PROSITE; PS51783; PH_BEACH; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 2.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
DR PROSITE; PS50178; ZF_FYVE; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000030746};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}; Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00091}.
FT DOMAIN 2417..2542
FT /note="BEACH-type PH"
FT /evidence="ECO:0000259|PROSITE:PS51783"
FT DOMAIN 2570..2863
FT /note="BEACH"
FT /evidence="ECO:0000259|PROSITE:PS50197"
FT REPEAT 3002..3036
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 3087..3126
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 3435..3495
FT /note="FYVE-type"
FT /evidence="ECO:0000259|PROSITE:PS50178"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2044..2077
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2365..2403
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3135..3172
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3208..3228
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3240..3269
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3287..3335
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2368..2402
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3149..3164
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3212..3228
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3240..3259
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3289..3303
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3311..3325
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3505 AA; 393661 MW; 360DEC766E4B354A CRC64;
MSFMRKLMGN KGAPDPKSNS PDNSLGLMHL RKLFAEFRHP TAKATQKDQE DKLYNMLPLF
CKVFENAPSN DMTDKWGDIL QFCSHVSKLM VTEIRRRASN QSTEAASCAI VKFLEIESNN
QVSNGWSLLG AINLLSLGKH ALIDCMTAAS LPSTLVKCLY LFFDLPKLEN EDDTPEGSDF
SPKEKRVLLQ RIFVQYVLVR ISNHSSPAEE LARKDDLSLL FSAITSWCPA YNSMWRKSAG
EVLVTLSRHG LTNSVVKYIH EKGCVRHCIE NMQRVQELSP LELVEMFVTV FCFLKDSSEV
SQTLVDDFKS CQGYVFLSEF LLKLESNDGE EAVQALRNLV LLVGSLTTCG FCEIKPNAGS
TGSLFQMPGF CMPQPAGKGV SVRNIHAFQV LQSVFLKSNT SHLCGTILDV ISSIYHQDNA
NYFILEPQHT LPTFIEKIHT KPPDIQAFVH ALGRRCLRNA WDAEFETTKG EESKLFELIE
FIVFNLNFVP CKELISLSIL IKSEHSISTS ILCMKTLLHI LRYHSVYRDV FREVGILEVM
VTCMHRYAAL LKEPHNDTEN ENIDPEQQEL GHLVMESLAL LLSGNSSNAG VFRECGGARC
AHNMVPYTNC RQMALNIVQQ LVLSPGGDDD MGTLLGLMPT ATITNLELKT HILKSLLNVL
RESHRTRTVF RRVGGFVYVM SVLVSMEGCL AEPPKSPWDS VPRKDILQML RTVFSTLTVA
MRYEPANAKF FASEVRYDSL TEAVRLLGCF STYIDIQTES EDTKPTDNTE LFTNLFQHSK
EDKIQKSIPV ILISACQMFR YLYDMALDAF DRPSSNYAKT DSPLLLKKHM SVIEEPCNNQ
TLNKPKRGST GSMNINISSL IDHPVIVHAG AVLSIFHLLP AVEHYSDSLD ALNLKSCISE
ILKSLLRPER NQQIMCDAGF PHELLSHGSV ALADESFPLH PPLQFMFERL ASQSLTPRDL
RDFLRLGSPL NCRPVEDVQD VGSNGTWNDP DLISKSVGIE DKTSTMEIEK KLKSAGRTVP
LTRVKCLVSM TTPRDARMHG ATVTPAFVEF DMSAEGFACL YLPSIAPQGP PTPSVVGGVV
GTSDPIVYGG VGSGERVFPP PSGLTYSSWF CVDKFSNPTL DAHPVRLLTV VRNIQGRDEN
LICLSVYLTS KDNALVVSTQ ETYMPTSVTG TEQEQEPVLN DNTVRFWHPE LTQEGQWHHL
VLVFHRAGIM KNSNVSLFVD GEHINTHKLH YISPNLGAGG TASPTAFTSV FCYIGTPPQL
RRLSRLTWRQ GPCHLLEDIV STNTITNVYN LGPTYIGSFQ AALMESSEVS LPFITEEKVV
FGVHAHALSQ MTVAKIRKIY NKYDSKSIAK QLAMSAHENA TPIRILHNSA GHLAGSARSL
GAILMGYLGV RTFCPRPVAK MLDNVGGTAA VLGLIAMAKD VEGLYAAVKT LVCVVNSSRS
ARWDMDRIRG YQMLAMLYKK KRSLLNSHIL HLTFSLVGTL DSGRESAVIP NRVAFEDLLC
DLEVWHEAPG DLQKSLYEHF YELLTDSSDA KGNGIMMRDI GLVSSLLFVL KDTCISYNTS
KIIANVIGEL LYTAPHHKSL LRYGQFILST IPPVNINEKT VDINQPSTDD NTNSIIQNVK
LRNTLLDVTL KLILSDSSNL NIHVCDDILK TLGFDWLMLF FQENLHPTTV VLALRILVTM
FRNNNNVQRF REGSCGGGWL EDTENVLKNQ MAAMLGFNLG ITNKTHDKEH STEVSHIPGF
TVLQWTLPKH NHISSVYFLL MALLLGQHNK DLPTDVELSL DAVWTVIFGV PASKPVSLLA
KEKVELCSEA AIVILAMIRN AVNEEIDDND KSKDYPLILL QFLLFLYHNQ TDFLNLCTTP
DFIMALSATL FSYPTPEIDS DVTTPTEEFK PFPDSEPIVL LKQPSKTSDS ILNGHPARRF
IIDFLRTIVI DSFSTKSTTV IDLMLDGYPE HASRAQQKQF QTEMLNILME HLLAADVYLE
YLQERLKKCS ILPIDSVSSQ TGVLDSLHKL TNNRNLVFGP GNYDQEFVGC LTYCLLQLTE
DPESSGANLS ESKARTTTWH VEPDSNDNVD NTTTSIEPNS VLSEGMQLVA NAARRVWDEL
YIFKKPALEE LFRITFNNNT NNKPISTPDL NSVRLMIQES ASRIWVTYAE SERKSPFTNT
DKLQTQIQSK LQKVGSGVLR LASRRTKREI PTKISPACNV HVNYYHGWVN SHITLVKDVI
NFQHKQFQQS QLHLERYLVE EWLTMENELL RVRGLWGPQY GCRLDKYTLD MTEGPSRMRK
KMILDDMFYV HYPYRPDLED SPLRYKVAIS FDSKEYSEQY RPCGILAVNK LPIIRNDNVD
ILSADTSTQN SPEVDISKMS KLISNKSGID DDGQDTDCNN TEEDKTDGQL DREGEGQHEE
QTTYNKGDNQ AILRLLGEGE KISHMFRCAR IQGLDTAEGL LLFGKDHYYV VDGFTLLKTR
EIRDIESLPP GYHEPIIPKS SMSSGGALKR MFSKFSYDEV CEVHKRRYLL QPIAIEVFST
DGRNYLLALP RKTRNKVFAK FQSMGTAITD NAQQSVSGQR QNVKVESGGG IISSLIGEKS
VTQRWERGEI NNFQYLMHLN TLAGRCYNDL MQYPVFPWIL ADYDSQELDL SNPSTFRDLS
KPMGAQTPER LKQFEKRYNE WDDPQGETPP YHYGTHYSSA MIVASYLVRM EPFTQHFLKL
QGGHFDLADR MFHSIRENWF SASKHNMADV KELIPEFFYL PDFLLNANNF DLGCKQSGVA
LSDVVLPPWA KSDPKEFIRI HREALECDYV SSHLHHWIDL IFGYKQSGQP AVEAVNVFHH
LFYEGNVDIY SIDDPLKKSA TIGFINNFGQ IAKQLFKRPH PQKKLNIRYL DPISGMSVTT
DRLFFHNVDN LKPSMQPVKE LKSAVGQIIH NEKSVLAVEQ NKVLIAPTYG RYLAWGFSDL
SVRIGNYESE KASAIFECLD NGVILCAACP NTKVFITGGT SCVVNVWEHI PKERKVVLKQ
PLYGHTEPVT CLAASQAYHI IVSGSRDRTC VIWDMSRLLF VTQLRRHIAP VAAVCINELT
GDIATCAGTY LHLWSINGEE IACVNTSTGR NQQILCVAFS QLKEWDSQNV IMTGSSDGVV
RMWSIEYVQV PDETKTKLKE DNTDSTNKDN SKSVRNTSIS PPVNVPKISR RESCDSYSEL
RSATDMLRDF KDPDFLVAKG CELGSSAESE SHLVQKMKDK DCESSRDRMS NDFSMLERLE
SNMSTTSSTS DIYKTDDGTS TNGDLEEYAP VEPNNESLAA LGEDALDKSF GSQPSQSEPC
LVSAVGDNNE VRSKSHGDLK SGGDSETDSI KSSSSGYVVI NDSDIQQVKF TERPKPTKNT
LRDGFKWLRQ IVFRSKLTMH TAIERKDNKE PAAVTALAVS RDHKTVFVGD ARGRIFNWTV
TDQPGRVVAD HWMKDEGVDS CLSCNVKFSF SERRHHCRNC GKVFCSRCSR YETEIRRLRI
VKPVRVCQAC YNIVKAADAI SIGKL
//
