ID V4A2P6_LOTGI Unreviewed; 1017 AA.
AC V4A2P6;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 03-MAY-2023, entry version 39.
DE RecName: Full=chitin synthase {ECO:0000256|ARBA:ARBA00012543};
DE EC=2.4.1.16 {ECO:0000256|ARBA:ARBA00012543};
GN ORFNames=LOTGIDRAFT_143023 {ECO:0000313|EMBL:ESO98138.1};
OS Lottia gigantea (Giant owl limpet).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Patellogastropoda; Lottioidea; Lottiidae; Lottia.
OX NCBI_TaxID=225164 {ECO:0000313|EMBL:ESO98138.1, ECO:0000313|Proteomes:UP000030746};
RN [1] {ECO:0000313|EMBL:ESO98138.1, ECO:0000313|Proteomes:UP000030746}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[(1->4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-
CC D-glucosamine = [(1->4)-N-acetyl-beta-D-glucosaminyl](n+1) + H(+) +
CC UDP; Xref=Rhea:RHEA:16637, Rhea:RHEA-COMP:9593, Rhea:RHEA-COMP:9595,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:17029, ChEBI:CHEBI:57705,
CC ChEBI:CHEBI:58223; EC=2.4.1.16;
CC Evidence={ECO:0000256|ARBA:ARBA00000319};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KB201266; ESO98138.1; -; Genomic_DNA.
DR RefSeq; XP_009051165.1; XM_009052917.1.
DR AlphaFoldDB; V4A2P6; -.
DR EnsemblMetazoa; LotgiT143023; LotgiP143023; LotgiG143023.
DR GeneID; 20234642; -.
DR KEGG; lgi:LOTGIDRAFT_143023; -.
DR CTD; 20234642; -.
DR HOGENOM; CLU_004002_0_0_1; -.
DR OMA; RFEIRKT; -.
DR OrthoDB; 1331060at2759; -.
DR Proteomes; UP000030746; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004100; F:chitin synthase activity; IEA:UniProtKB-EC.
DR CDD; cd04190; Chitin_synth_C; 1.
DR InterPro; IPR004835; Chitin_synth.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR PANTHER; PTHR22914; CHITIN SYNTHASE; 1.
DR PANTHER; PTHR22914:SF42; CHITIN SYNTHASE; 1.
DR Pfam; PF03142; Chitin_synth_2; 1.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000030746};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 64..85
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 97..121
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 127..148
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 168..189
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 195..215
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 346..368
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 403..423
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 629..645
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 839..864
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 876..898
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 904..924
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 931..954
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 966..985
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 1017 AA; 116365 MW; D4802EC8FFF97E20 CRC64;
MLCTTFFLLV LGTSTLSKLS FIFITFYINP GTGFGFSHQD QFVENTTHIY QLKKSITPTI
DIKWIWSLIL ILCAQYLFTF LHSLWKMIFK KTGSIRCIPF LVSMVTETLH SIGLCTFIFY
VLPSFDPLIG CMLTWNVASI PGLLKIFLPS VSSGSKPVKN DLKTKTYVRR FVDTVMVTLH
LGCIATWTYN SYYNHNIYVT ILLPISLFLI SISWWDNFVT TSKENDTQLN GCMSSVKDSL
EECKIRTTFI TSAWKIFLTI GLPALCFSYE HVECLETFFF TKRQYAKDCS VFTNIELRDS
RPPIIGVPVT ESCHNMLPLL VACLNILSSV ICYKTGKSAC KIMAQVPCFT VPVMLSGPLC
VAIIISTYTF PEEITRFFGC TLPWVHIGDS AISDFLLHFT LKWWIPIGLL GYITMLYIVG
HTFTPRSERL ARTETLFVKP LFCGALVEQS ILLNRRRDEE DNREYKVSGV WLSGDQIVDD
SEDIPDKKKD TIPLIYICAT MWHETEQEMI NMLKSIFRLD SDQSARKLAQ QFFDLTDPDY
YEFQGHIFFD DAFQSHSDDD YDYMVNDFVK QLVRTMQKAA NDVHGASMVI KPPKRILTPY
GGRLEWDLPG GNKIIAHIKD KAKIRHRKRW SQVMYMYYFL GFQLLNQKLS MKRKKVRAEN
TFLLALDGDV DFQPMAVQIL VDRMKTNPNL GAACGRIHPI GSGPMVWYQK FEYAVSHWLA
KATEHMLGCV LCSPGCFSLF RGSALMDDNV MKKYTTPPTE ARHYVQYDQG EDRWLCTLLL
QQGYKVEYAA ASDSYTFAPE GFYEFYNQRR RWTPSTMANI LDLLTTWNTT TKNNDDISWL
YMFYQASLMV SSIITPGTIF LLVLGALRTA YKDIPLYGAL VINLVPVVFF VFLCLKAPSK
YQLAYAGILS IFYSLLMMLV LVGLVRQAAE YGFCSVTTIF LTTVSSIFVV SAFLHPQEFT
CILHGFLYFL TIPSMSMLLV IYSLANLHNV SWGTREVKQA VPPPNKQVLT RIIYGLH
//
