ID V4A396_LOTGI Unreviewed; 3370 AA.
AC V4A396;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=VWFD domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=LOTGIDRAFT_166089 {ECO:0000313|EMBL:ESO87791.1};
OS Lottia gigantea (Giant owl limpet).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Patellogastropoda; Lottioidea; Lottiidae; Lottia.
OX NCBI_TaxID=225164 {ECO:0000313|EMBL:ESO87791.1, ECO:0000313|Proteomes:UP000030746};
RN [1] {ECO:0000313|EMBL:ESO87791.1, ECO:0000313|Proteomes:UP000030746}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KB202823; ESO87791.1; -; Genomic_DNA.
DR RefSeq; XP_009061402.1; XM_009063154.1.
DR STRING; 225164.V4A396; -.
DR EnsemblMetazoa; LotgiT166089; LotgiP166089; LotgiG166089.
DR GeneID; 20240254; -.
DR KEGG; lgi:LOTGIDRAFT_166089; -.
DR CTD; 20240254; -.
DR HOGENOM; CLU_225048_0_0_1; -.
DR OMA; DICRING; -.
DR OrthoDB; 2970897at2759; -.
DR Proteomes; UP000030746; Unassembled WGS sequence.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR CDD; cd01099; PAN_AP_HGF; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 3.50.4.10; Hepatocyte Growth Factor; 3.
DR Gene3D; 2.10.25.10; Laminin; 3.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000421; FA58C.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR003609; Pan_app.
DR InterPro; IPR001846; VWF_type-D.
DR PANTHER; PTHR14949; EGF-LIKE-DOMAIN, MULTIPLE 7, 8; 1.
DR PANTHER; PTHR14949:SF49; VWFD DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00024; PAN_1; 3.
DR Pfam; PF00094; VWD; 4.
DR SMART; SM00181; EGF; 3.
DR SMART; SM00473; PAN_AP; 3.
DR SMART; SM00216; VWD; 4.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR SUPFAM; SSF57414; Hairpin loop containing domain-like; 2.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS01186; EGF_2; 1.
DR PROSITE; PS50022; FA58C_3; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS50948; PAN; 3.
DR PROSITE; PS51233; VWFD; 4.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000030746};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 23..176
FT /note="F5/8 type C"
FT /evidence="ECO:0000259|PROSITE:PS50022"
FT DOMAIN 190..260
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 425..609
FT /note="VWFD"
FT /evidence="ECO:0000259|PROSITE:PS51233"
FT DOMAIN 964..1048
FT /note="Apple"
FT /evidence="ECO:0000259|PROSITE:PS50948"
FT DOMAIN 1396..1591
FT /note="VWFD"
FT /evidence="ECO:0000259|PROSITE:PS51233"
FT DOMAIN 1958..2042
FT /note="Apple"
FT /evidence="ECO:0000259|PROSITE:PS50948"
FT DOMAIN 2047..2131
FT /note="Apple"
FT /evidence="ECO:0000259|PROSITE:PS50948"
FT DOMAIN 2385..2572
FT /note="VWFD"
FT /evidence="ECO:0000259|PROSITE:PS51233"
FT DOMAIN 3183..3370
FT /note="VWFD"
FT /evidence="ECO:0000259|PROSITE:PS51233"
SQ SEQUENCE 3370 AA; 377745 MW; 7F6B9D0E60A7D644 CRC64;
MFRITRTSIG LFSVRVTCFA PDCNAPLGLE SESIKNEQIK ASSLSLDQSL SKLRYGCCDG
ESFAAWCPAE NQNGEWVEVS FYGPTLVSGI KLQAPQSIEE VTSNLTKFSV QFELATSPPG
VLTTYIDDNN QTVFESHLDT ESKSNLTFPS VLIRKIRIVV EEFNVNPCFR LEVLGCSSTE
TVVPVGIKEP KLRLDYISED DIKLVCETTD LPSLSIQYQV TWFRDNIAIQ TSLLPSLSTS
QTLQVTIQDF KNQKSHQCSI KACHSLDCSK DIFTDKVESD VFMPGVTLET EDSLQICEGE
QGSFKVVGNA PPSFICLINN LKEDCQIYLQ TTVADDNPVR CTNDRILPQI TVPSASSQSQ
CKWTYSNENW MSPIEIPVMA NQDLLIDGTR MSSITVTVVP GECLSCMSKS AQMIKVETCD
KDEISVCKSL PTGHITTFDN VVYTSQLNGE QILYQSKEMP YSVHVFNTEC DGVADAVCSC
AVAIRSNDDV VVISGCKGND HLEVDMYLNG DLEPDTTIYS FNSGREYEVY LPTGTEVSVK
QFNDFISVWI YSSPLDFNNT LGLCGLYDNS DSNEYIKQDG VMVNDNVNND FSKTWRVDRK
DTIFYGICPD QMTSAPKDVR ESCECRSADS TRCHSSHVLT CPALKAYFPD YEVTSDLVKY
TASAPVNCLM GVQVIDEYIQ KPDPVNVPVW RNGWNEANAT EFCQTISNSK ISTICNSVVQ
NYTDDELTNC INNIKYTGDR TFFRLLEDGL EERCSKQIYK NLTNLVPDST INSLCPNSCS
NNGNCINGIC YCAGFIGDDC SVKAKDKPVI TRLNNDGLCN TRNQPCDSVV VEGYHFVKGT
NFKCQFKKIE VNATHYSSIG EWIDSTDIEY INIGLVSCSL PKAGYYMIRA SNNGLDYSNE
VFYFANDRDC YNCNTTEGTC AQRDNVCIID GKCYFENVFN DRNHTLICKP DKDADGWTYT
DSPCIESTAT WNTTESRAIG FHNHKTYNNV VDLEACQKLC AGELEFSCRS VDYNTENQSC
HLSKYRRTDV QSYYSNFGSN ITNSEWNCEK EHCSGLKVEW KMKSALVPKK SNFTEIADVW
SYDVCRLRCL AMETCTYVIH NAMRGLCLWS TDEISEDQEM VSAPGWSYHL IECKPGSPSD
REGPSVSSAK IIPTFNGVGN KDQYECQYSE VVSNNKRFVR FDILWNFNGQ WIYENTKEDN
VTESYLPEKY IDKVVYGTKI MCAVSVCYYD NCEDTRSTLA VSDAYEIGIL VSTNEDLVLR
EGEEGENIQL HATAPPYILC REKGVSNMTV CKVKLTIKAE DNGKLDCPGG YKVAQTAIRI
TNDKDEEMSV CNMELTNSDW QNMYNINIKA ATDNKYDGDA IGSLNISAHY MVEEKSEVTE
ALIESKLTIV DVDRSAVCFS VNDPHMTTFD SRYYNNYHQG EYVLYKHSEL PHSVHAFYRS
CNGRVSCTCA VAIKVDDDVV IIDKCGESAD NIYGFTPISV KLFRNGLLTP GFQIFSEYGG
REYRVVLPTG TVVYVSRSVI RGYNYVNVWI KASASDFNHT KGLCGSYDDD VDNDLMKRDG
TLSTDTSETP DDFSLSWRVD KKDTLYTGAC PEENAKPTPK VRETYCYCHD DSDSCNPGNH
LQICPFENKG SDITLRLQKE SLFPTKCRKE NTGFSYPEFE YDINAVPGEY NFPTKSGMSE
DYVNGICKFS LEFLDSDSNC KDVPNVLYDY SFKSCVEDIK ITGELAWNKA AFENIKVQCE
IQLASNVSLW TTNADGALAP PTSITDHLCI AACGGAGKCV KGVCECKEGF SGPDCFLDEN
EAPNLFYLGN KGLCDLQKDP CDRVHVFNNN TIDNEALFCH YYKVESNETT YNIIGEEETR
QAEYISVNEL ICPLPEKSSY VIKISNNRTV YSSPALLLVY DSLCYNCSLN SGACMIKDSA
CLIDGTCFET GEYNPDNSRE FCDPMLNTTG WQVANDSCET LDLLWLQTKD KYYINSTVLS
SSTSNYSDCQ NLCLAEDNNG CLSFQHNMTT NKCSLNAQSR STAFELFVQD DNQETYYSEW
ICDNNPCATR GITWIRHAGF AILGEKILKE ISGVSSLSAC RNLCLREKDF VCRAYQLLVE
AKTCSLSAAS SADANNDFVR WPGYIFEEWT CKSGNDLPIA SKNPTAKIET DMNSNYTLSC
EFPAIENRVN KTFKYLVEFW LDRQHVIQMT NVSLEESADT GKVFLNPEQA RGHEYGTKLS
CAVQTCLQEK DGSCMLGALR SSNNIELKIE FENQDEMELV EGQPSKSIVI RSNMPPSFVC
QSTEDCSFMV YGKLQEDEND TLCFGGEVMS QAVLGFKSMC GIKIDSQNWQ DKHEIPLKAK
VDSLKDGNKD RHLNFWLDVM NEDMSVFKTD LNTFKLSIID KDRSAVCSSM SGAHLITFDG
RYYDILSSGE FVMYKHTTLP LEVRTYYRAC FKNGMCNCAV TVKAGDDVIL IDRCGADLKT
SDKQPMIAKI ILNDDLTPGV YIDQIGAGMK YKITLPTGTV VIVGLDNQHL SAYLNVWIVP
STQDWMKTQG LCGDFDGDNT NDLINNFDGK SPVVMSPNAF TASWRSAKDS SLYNGYCKTD
SDIQIEDMIY CDCINNNTSP CTSNGDIKPC PHQNRLTFSE GEDVTQLFVK IAEKSTCSKT
PEFQYSADYK LQEYDWPTLS GITEGNATAY CDEVISNSKP ANMCLAIDNI HADFIMKSCL
SDIKMNNNRK WLGTTVNSLL QACVIELKLQ GADAGKEDDG GRNRTEVNQS LYDIICLNDC
SGNGTCVQST CVCNEGFIGP DCSVEDNEPP EIYRLVNDGI CDISQAACDQ VTVYGNKFVK
SDNLTCKFQR ILIQDMNYTV IADENTVEVA AMFVSFSHIV CKLPTVYSYL ISISNNEVLY
STETVFSVIH PNCHDCDTAG FCSIKPETCF FGLECHKFGE KNPENDTLIC DPFENYYDWS
TVKDFPYLEL TPTVKAEQDG ENFKFVCEFQ LPQRSDLKLF LKWFHDDAEI KMLDLNLEDT
MAEIDIKYVT GFKFGSKIEC GVLACYAASC ESTYSPPKKT IISFMAEIKL LTTKLSLIEG
QDPGFIETQL SVPLKYMCSQ DQECQIQVGV ILPEEDELQC SDSQYYYQTV FLSTDETQTC
LKKISDYPDT LKLELKASID GLVDGTTRSQ VMIGARVTAG EEVVYNDTIG STSISIKDRD
TIALCGSLIH PHMTTFDGTT YNVFREGEFV LYKHTTMPYE VRAFFRQCDG KVSCNCAVSV
KSGDDVIIVD RCGASRTNQE KQPTTVTIYK NGDLTPGTRI YRYSEGKKYK IQLPTGTLVF
IQPGKKRHEK GYLNVWIQAS PTDYERTQGL CGTFDEDVDN DLQQPDGQVY AGQEREPDAF
SLQWRQVFMI
//
