ID   V4A3R4_LOTGI            Unreviewed;       972 AA.
AC   V4A3R4;
DT   22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT   22-JAN-2014, sequence version 1.
DT   27-MAR-2024, entry version 44.
DE   RecName: Full=Kringle domain-containing protein {ECO:0008006|Google:ProtNLM};
GN   ORFNames=LOTGIDRAFT_166152 {ECO:0000313|EMBL:ESO87851.1};
OS   Lottia gigantea (Giant owl limpet).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Patellogastropoda; Lottioidea; Lottiidae; Lottia.
OX   NCBI_TaxID=225164 {ECO:0000313|EMBL:ESO87851.1, ECO:0000313|Proteomes:UP000030746};
RN   [1] {ECO:0000313|EMBL:ESO87851.1, ECO:0000313|Proteomes:UP000030746}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23254933; DOI=10.1038/nature11696;
RA   Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA   Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA   Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA   Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA   Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT   "Insights into bilaterian evolution from three spiralian genomes.";
RL   Nature 493:526-531(2013).
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00121}.
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DR   EMBL; KB202823; ESO87851.1; -; Genomic_DNA.
DR   RefSeq; XP_009061455.1; XM_009063207.1.
DR   AlphaFoldDB; V4A3R4; -.
DR   STRING; 225164.V4A3R4; -.
DR   EnsemblMetazoa; LotgiT166152; LotgiP166152; LotgiG166152.
DR   GeneID; 20240268; -.
DR   KEGG; lgi:LOTGIDRAFT_166152; -.
DR   CTD; 20240268; -.
DR   HOGENOM; CLU_334411_0_0_1; -.
DR   OrthoDB; 211181at2759; -.
DR   Proteomes; UP000030746; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.120.260; Galactose-binding domain-like; 2.
DR   Gene3D; 2.40.20.10; Plasminogen Kringle 4; 2.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   InterPro; IPR000001; Kringle.
DR   InterPro; IPR013806; Kringle-like.
DR   InterPro; IPR038178; Kringle_sf.
DR   InterPro; IPR035976; Sushi/SCR/CCP_sf.
DR   InterPro; IPR000436; Sushi_SCR_CCP_dom.
DR   PANTHER; PTHR19325; COMPLEMENT COMPONENT-RELATED SUSHI DOMAIN-CONTAINING; 1.
DR   PANTHER; PTHR19325:SF573; SUSHI DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF00051; Kringle; 1.
DR   SMART; SM00032; CCP; 3.
DR   SMART; SM00130; KR; 1.
DR   SUPFAM; SSF57535; Complement control module/SCR domain; 3.
DR   SUPFAM; SSF49785; Galactose-binding domain-like; 2.
DR   SUPFAM; SSF57440; Kringle-like; 2.
DR   PROSITE; PS50070; KRINGLE_2; 2.
DR   PROSITE; PS50923; SUSHI; 1.
PE   4: Predicted;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW   ProRule:PRU00121};
KW   Kringle {ECO:0000256|ARBA:ARBA00022572, ECO:0000256|PROSITE-
KW   ProRule:PRU00121}; Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000030746};
KW   Signal {ECO:0000256|ARBA:ARBA00022729};
KW   Sushi {ECO:0000256|PROSITE-ProRule:PRU00302};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        935..955
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          53..108
FT                   /note="Sushi"
FT                   /evidence="ECO:0000259|PROSITE:PS50923"
FT   DOMAIN          488..564
FT                   /note="Kringle"
FT                   /evidence="ECO:0000259|PROSITE:PS50070"
FT   DOMAIN          573..638
FT                   /note="Kringle"
FT                   /evidence="ECO:0000259|PROSITE:PS50070"
FT   DISULFID        79..106
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT   DISULFID        510..549
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00121"
FT   DISULFID        536..559
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00121"
SQ   SEQUENCE   972 AA;  107533 MW;  2B8739C6A476D30E CRC64;
     MATRACSGRL YNTLVKFSVI IWTCVYVIRG ELPINYGSLV IACVLFSVPG IRSNCEEPPP
     VPNAIRQGQW QGGDVSYSCY PHHVLVSGDL YRCCEEDIYD GDEPKCVYDC GAPRTIPGTL
     YSLGSTLQGS TISYDCDFPH EEFGSNSPDV QCDEETKQWT HTQFMCYDTS SANLALNKPA
     LHNGNSASYL VDGSDSTCNT VISDHHLIEI DLGQVVNVIK LEIIIGNELP LVNVSVLNSN
     NNILSTCKIS LTSIPPWTPT TLHCNPTYST RAPGDILYVA AKLLSPMQMS FCEMKVTATN
     YYGDCGKPPT QPGQEASYTT TGENSIATIS CVSPWHAKSG SNSIVCHLTQ WSQSSLECTL
     ESNIAENAVA MNVDGEAALD NDISTCYTGL NNGINNPNWQ IDLLALYSIS SISVTFGVNG
     MNIAHYIKIS DDNGGTRYCQ PEYPRDGVTL FDCPQGPVGK YINMTAAWPI HICDVKVHGM
     LHQGVLDCSM DSQGRDYKGY QTVTVFGKTC LPWLINSSFT AWLFPDVVAS NVANHCRNPQ
     TFEKERPWCL VSQTEWELCP VFECSSFCKT TTDGFQYDGE VSFAVSNKTC EMWRKSRFRH
     DFSGNVQHCQ NTYKDQTQPW CITDLATNTY EFCLIPDCPK TVPPTITVSE NSTGFDYENE
     LQTCMHWSPF PFMAPWNPLH IHLDYRGTIL NSFCPWSGMP IIRLFCIRHN LQLTFLDFIC
     DPGALAVENT ESSISSFFET TVALSSASPS VLTIDSSDMT SFTFTDQTLL SEAISMFETS
     SDNLQESTDV SLSDSLSEIQ SSTLIDIQPS TTIELLSITD ALSYYITTSS VASTHQLNTD
     TILEPSSQDS TTLQPSAFPL TDSVSESSPL VTSASSFLTN VTISRCPCLC NNNPFWDEAK
     IKVYKLRLFE LLHLDKRNLS STYRKKNCIR DNRPLAIATG GVGVTVIICV FLYLASSDVY
     LVYNQVIRIL KT
//