ID V4A486_LOTGI Unreviewed; 127 AA.
AC V4A486;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=Bcl-2 Bcl-2 homology region 1-3 domain-containing protein {ECO:0000259|SMART:SM00337};
GN ORFNames=LOTGIDRAFT_114161 {ECO:0000313|EMBL:ESO98728.1};
OS Lottia gigantea (Giant owl limpet).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Patellogastropoda; Lottioidea; Lottiidae; Lottia.
OX NCBI_TaxID=225164 {ECO:0000313|EMBL:ESO98728.1, ECO:0000313|Proteomes:UP000030746};
RN [1] {ECO:0000313|EMBL:ESO98728.1, ECO:0000313|Proteomes:UP000030746}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
CC -!- SIMILARITY: Belongs to the Bcl-2 family.
CC {ECO:0000256|ARBA:ARBA00009458}.
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DR EMBL; KB201205; ESO98728.1; -; Genomic_DNA.
DR RefSeq; XP_009050370.1; XM_009052122.1.
DR AlphaFoldDB; V4A486; -.
DR STRING; 225164.V4A486; -.
DR EnsemblMetazoa; LotgiT114161; LotgiP114161; LotgiG114161.
DR GeneID; 20231054; -.
DR KEGG; lgi:LOTGIDRAFT_114161; -.
DR CTD; 20231054; -.
DR HOGENOM; CLU_085401_4_0_1; -.
DR OMA; PRARWAC; -.
DR OrthoDB; 2909137at2759; -.
DR Proteomes; UP000030746; Unassembled WGS sequence.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR CDD; cd06845; Bcl-2_like; 1.
DR Gene3D; 1.10.437.10; Blc2-like; 1.
DR InterPro; IPR036834; Bcl-2-like_sf.
DR InterPro; IPR046371; Bcl-2_BH1-3.
DR InterPro; IPR026298; Bcl-2_fam.
DR InterPro; IPR002475; Bcl2-like.
DR PANTHER; PTHR11256; BCL-2 RELATED; 1.
DR PANTHER; PTHR11256:SF48; BCL-2-RELATED OVARIAN KILLER PROTEIN; 1.
DR Pfam; PF00452; Bcl-2; 1.
DR PRINTS; PR01862; BCL2FAMILY.
DR SMART; SM00337; BCL; 1.
DR SUPFAM; SSF56854; Bcl-2 inhibitors of programmed cell death; 1.
DR PROSITE; PS50062; BCL2_FAMILY; 1.
PE 3: Inferred from homology;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Reference proteome {ECO:0000313|Proteomes:UP000030746}.
FT DOMAIN 18..119
FT /note="Bcl-2 Bcl-2 homology region 1-3"
FT /evidence="ECO:0000259|SMART:SM00337"
SQ SEQUENCE 127 AA; 14219 MW; 67592B9305D88048 CRC64;
MTFKVRLKPS DDELSNFVAT AGETLEKHYP HVYSDVSRKM ATTMSSPEVV KSAITTILEA
IFRCDINWGK LLSLLAITSS FALECVLQGH AEYVDNLVEC VVYFVSYNIN EWLQVQGGWV
GILLLIS
//
