ID V4A7K1_LOTGI Unreviewed; 1794 AA.
AC V4A7K1;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE RecName: Full=Dedicator of cytokinesis protein 1 {ECO:0008006|Google:ProtNLM};
GN ORFNames=LOTGIDRAFT_232874 {ECO:0000313|EMBL:ESO92727.1};
OS Lottia gigantea (Giant owl limpet).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Patellogastropoda; Lottioidea; Lottiidae; Lottia.
OX NCBI_TaxID=225164 {ECO:0000313|EMBL:ESO92727.1, ECO:0000313|Proteomes:UP000030746};
RN [1] {ECO:0000313|EMBL:ESO92727.1, ECO:0000313|Proteomes:UP000030746}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
CC -!- SIMILARITY: Belongs to the DOCK family. {ECO:0000256|PROSITE-
CC ProRule:PRU00983}.
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DR EMBL; KB202014; ESO92727.1; -; Genomic_DNA.
DR RefSeq; XP_009056417.1; XM_009058169.1.
DR STRING; 225164.V4A7K1; -.
DR EnsemblMetazoa; LotgiT232874; LotgiP232874; LotgiG232874.
DR GeneID; 20249072; -.
DR KEGG; lgi:LOTGIDRAFT_232874; -.
DR CTD; 20249072; -.
DR HOGENOM; CLU_000595_2_1_1; -.
DR OMA; LWDNQAF; -.
DR OrthoDB; 8258at2759; -.
DR Proteomes; UP000030746; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd11872; SH3_DOCK_AB; 1.
DR Gene3D; 1.20.58.740; -; 1.
DR Gene3D; 1.25.40.410; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 1.20.1270.350; Dedicator of cytokinesis N-terminal subdomain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR027007; C2_DOCK-type_domain.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR026791; DOCK.
DR InterPro; IPR043161; DOCK_C_lobe_A.
DR InterPro; IPR043162; DOCK_C_lobe_C.
DR InterPro; IPR032376; DOCK_N.
DR InterPro; IPR042455; DOCK_N_sub1.
DR InterPro; IPR027357; DOCKER_dom.
DR InterPro; IPR046769; DOCKER_Lobe_A.
DR InterPro; IPR046770; DOCKER_Lobe_B.
DR InterPro; IPR046773; DOCKER_Lobe_C.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR45653; DEDICATOR OF CYTOKINESIS; 1.
DR PANTHER; PTHR45653:SF10; MYOBLAST CITY, ISOFORM B; 1.
DR Pfam; PF06920; DHR-2_Lobe_A; 1.
DR Pfam; PF20422; DHR-2_Lobe_B; 1.
DR Pfam; PF20421; DHR-2_Lobe_C; 1.
DR Pfam; PF14429; DOCK-C2; 1.
DR Pfam; PF16172; DOCK_N; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS51650; C2_DOCK; 1.
DR PROSITE; PS51651; DOCKER; 1.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000030746};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 9..70
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 418..609
FT /note="C2 DOCK-type"
FT /evidence="ECO:0000259|PROSITE:PS51650"
FT DOMAIN 1217..1626
FT /note="DOCKER"
FT /evidence="ECO:0000259|PROSITE:PS51651"
FT REGION 1642..1794
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1642..1700
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1716..1751
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1794 AA; 207449 MW; F969A6E6086399B5 CRC64;
MTVWRKTDAK TKLCVAIYNF DGQGRCKLPL EVGDTLQIDE ECDGWYKGFA LKNKKLHGIF
PKSYVSIKES ITEIHGGMEI VTPREPAVAQ EISAVLKEWN QIWKMLYVLR GKDFDRVKEM
LNELLIWRQK ALSSKLTIEE LGALQQKVTK KIDFGNALLN QDLVVRDKMG NVLNHDKNSI
IEVFRRHVLA AENIKNIKLE DAGIENENES KFSWPSTFNL FVMLRNFVVK IGEDAEIIMN
LYDAKEAEFI SENYVVKWTK EGVPKDIDML NNFKVVFTDL GTKDRYRERV FLIFQIVRIG
VMDPKSLSPK NTQRVRRPFG VAAMDISEII AGTKEFNEDQ QHFIPFQQCG EEYMDSVVKK
VIVAKDINHK GQGLWVSMKL LPGDIKHVQE EFPHVITQGC SFARKIGFPE VIMPGDVRND
IFVTVMSGEF YKSATKTTDR NVEVTVLVCN SRGDALQEVI SYGSGDSMSG EYKSVVYYHE
DKPKWFETLK VTISSTEEEF RGLHLKFLFK HRSSAEAKDK SEKPFAMSYI RLMNENGTTM
EDCVHDLLVY KLECKKHEDR GYLNLPTTKR ELEHRFANHP TTGKVHLQSK SGSIVYSNKD
SFTIQTFVCS TKLTNNLDLL GLLKWQEVLH DTKNLQKHLE HLMKEGGEEI VKFLQDLLDS
LFNILMQNTN SELCDNLVFD ALVYIIALIS DRKYHQFRPV LDAYIDSNFS FAMAYNKLMA
ILKYYVDNAN EKSVHEQSLL CAMKSLEYIF KFIIKSRQLF ALINEGRGKQ QFEMTLKQLL
LSINGMMMYT SDQTLLIQGA ALKYISSIVA DVITVFDPIE LSTLMVQFIA NVPRDRLSRQ
KMKCINDLVH TDLFKRSDCR PVLITAIFQH TKTMMDRGVE VEECIDVLSD IMHCLYQPQT
GLHESDISIV TREILRTVIQ TAIGMDRKSK AVGKCVAVML SILRQMSENH YFNYIESFPT
NFDLLDFLME ILMVFQDLVG NSVFPKDWVE MMLIQNSIIL RALRFFANTI HDKFSNPFEQ
QLWSNFFHCA KDFLTQDALQ LERFSINKRN KIVTKYKDMR REAGFEIRSM WFNLGHNKIN
FIPDLVGPIL EVTLIPETEL RKATIPIFFD MMLCEYTQPI PKSNNRIQGN FNLVENEMIT
QLDILVEGGR GDEEYQELMY DILYSMCLGH STVREQGLAF VEMVRKLLQR LLEYRLIIKD
EVKEHRMSCI VNLLDFYHAI NRQEMYIRYL HKLYHLHLEC DNFTEAGYTL MLYAKLLNWS
EDNLPPMLHN NKYPDAITHR ELKEKLYYDI ISCFDKGKMW EKGIELCREL TLLYEQELFD
YVSLSKTHKR LAELYDNIMK QMRPEPEYFR VGYYGRGFPS FLQNKVFIYR GKEYERLVDF
SSRMQILFPN AELMRTLDPP GDDIKDSPKR HLQINAVTPI MELKHQFQGR DVGEQILKYY
RVNEVQKFTF SRKSDESPND IAKMWLERTN LVTSYPLPGI VGWYPVVSTC TFAVSPLETA
IETLENKNKK IHSAIEQHRI DPAIRVDNLS MLLKGVVDPA VNGGISMYKV FYNGEYILQS
DSMEKDSELV EKLKQLTFYQ VTLIREALMI HRRKVPEDLK PLHSNMEQRF AEMCNIIERE
YGIRVADKGF ASASLRRNQS IASTTSIRSS EFAQSPPAVD TNLLTPNKNS PGHRAQSVWV
RPDKTNSPSP GKSLQSKLNE QLVARRPPRP ESDKSPRPPS NQFRPDQFLS TSSLSLASNT
TVTSDTSDAF SSDEPPPLPE KTAYADYTNT NKPQPPLPVE AERDKPPPVP KKPH
//
