ID V4A7Y8_LOTGI Unreviewed; 677 AA.
AC V4A7Y8;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 13-SEP-2023, entry version 38.
DE RecName: Full=Threonine synthase N-terminal domain-containing protein {ECO:0000259|Pfam:PF14821};
GN ORFNames=LOTGIDRAFT_105242 {ECO:0000313|EMBL:ESO91165.1};
OS Lottia gigantea (Giant owl limpet).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Patellogastropoda; Lottioidea; Lottiidae; Lottia.
OX NCBI_TaxID=225164 {ECO:0000313|EMBL:ESO91165.1, ECO:0000313|Proteomes:UP000030746};
RN [1] {ECO:0000313|EMBL:ESO91165.1, ECO:0000313|Proteomes:UP000030746}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000256|ARBA:ARBA00001933,
CC ECO:0000256|PIRSR:PIRSR604450-51};
CC -!- SIMILARITY: Belongs to the threonine synthase family.
CC {ECO:0000256|ARBA:ARBA00005517}.
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DR EMBL; KB202283; ESO91165.1; -; Genomic_DNA.
DR RefSeq; XP_009057871.1; XM_009059623.1.
DR AlphaFoldDB; V4A7Y8; -.
DR STRING; 225164.V4A7Y8; -.
DR EnsemblMetazoa; LotgiT105242; LotgiP105242; LotgiG105242.
DR GeneID; 20229959; -.
DR KEGG; lgi:LOTGIDRAFT_105242; -.
DR CTD; 20229959; -.
DR HOGENOM; CLU_015170_3_2_1; -.
DR OMA; FNRCQHL; -.
DR OrthoDB; 5309433at2759; -.
DR Proteomes; UP000030746; Unassembled WGS sequence.
DR CDD; cd01560; Thr-synth_2; 1.
DR Gene3D; 3.40.50.1100; -; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.90.1380.10; Threonine synthase, N-terminal domain; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR031322; Shikimate/glucono_kinase.
DR InterPro; IPR029144; Thr_synth_N.
DR InterPro; IPR037158; Thr_synth_N_sf.
DR InterPro; IPR004450; Thr_synthase-like.
DR InterPro; IPR036052; TrpB-like_PALP_sf.
DR NCBIfam; TIGR00260; thrC; 1.
DR PANTHER; PTHR43515; THREONINE SYNTHASE-LIKE 1; 1.
DR PANTHER; PTHR43515:SF1; THREONINE SYNTHASE-LIKE 1; 1.
DR Pfam; PF01202; SKI; 1.
DR Pfam; PF14821; Thr_synth_N; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF53686; Tryptophan synthase beta subunit-like PLP-dependent enzymes; 1.
PE 3: Inferred from homology;
KW Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898,
KW ECO:0000256|PIRSR:PIRSR604450-51};
KW Reference proteome {ECO:0000313|Proteomes:UP000030746}.
FT DOMAIN 170..251
FT /note="Threonine synthase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF14821"
FT MOD_RES 285
FT /note="N6-(pyridoxal phosphate)lysine"
FT /evidence="ECO:0000256|PIRSR:PIRSR604450-51"
SQ SEQUENCE 677 AA; 75968 MW; E1F3B6038A84948B CRC64;
MGNPGCGKTT VGKILGEKLN RTVIDVDDDV LEPTWRMSVS EKLFDVGGER FLEEEGQALC
NFPTPTKSVI SLSGSNPLHQ KAMRHTKQNG VMIFLDVPQT DILDRLEKMK VDRIVGQEAG
IGMAEILNYR QSFYEKQHDI RVTCCSGDTP EIIASKLLSA LKNVHNDPGY VSTRGSDCDQ
PSTFLDTVLQ GLAKDGGLFV RSTELPTMPR YEQQRLIDMN YSDRALRILH RWINPLEIPG
GQLRDFVLKA YSKEAFQDAH VAPVRHLEKN QYLLELFHGP TASFKDYALQ LMPQLFSKAV
RNNDKHSKYL ILVATSGDTG GAVLDGFRRH SGTVFNDTGV IVLYPLSGIS ELQKHQMTTM
DGRNISVVGV NSNFDFCQST IKQIFNDIEF NKTMKEQFNT KLSAANSLNW GRLIPQIVYH
ASGYLDLVKQ RVIALGDEID ICVPTGNFGN ILAAYYVKMM GFPIRKLICA SNSNDVLTEF
FITGCYNLRS RHLLKTSSPA IDILKSSNLE RLLYHTSGNN GELIKNLYQD LQDHNHFSVS
EEHLRKLQSM FVVGSCSEEE CKSTIVQTLK NTGYLLDPHT AVAKTVADRY TSDVPTLITA
TAHYGKFGDS MLPWVDRHCV SDYTSEVVLN RLNDMSSHPP LHLGLKDMCQ KPITHTVQCQ
PDIQDITKYV VDIARKM
//
