ID V4A8J1_LOTGI Unreviewed; 677 AA.
AC V4A8J1;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE RecName: Full=RING-type domain-containing protein {ECO:0008006|Google:ProtNLM};
DE Flags: Fragment;
GN ORFNames=LOTGIDRAFT_182605 {ECO:0000313|EMBL:ESO91335.1};
OS Lottia gigantea (Giant owl limpet).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Patellogastropoda; Lottioidea; Lottiidae; Lottia.
OX NCBI_TaxID=225164 {ECO:0000313|EMBL:ESO91335.1, ECO:0000313|Proteomes:UP000030746};
RN [1] {ECO:0000313|EMBL:ESO91335.1, ECO:0000313|Proteomes:UP000030746}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the TRIM/RBCC family.
CC {ECO:0000256|ARBA:ARBA00008518}.
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DR EMBL; KB202283; ESO91335.1; -; Genomic_DNA.
DR RefSeq; XP_009058031.1; XM_009059783.1.
DR AlphaFoldDB; V4A8J1; -.
DR EnsemblMetazoa; LotgiT182605; LotgiP182605; LotgiG182605.
DR GeneID; 20244503; -.
DR KEGG; lgi:LOTGIDRAFT_182605; -.
DR CTD; 20244503; -.
DR HOGENOM; CLU_015209_0_0_1; -.
DR OMA; LESCKMD; -.
DR OrthoDB; 5387006at2759; -.
DR Proteomes; UP000030746; Unassembled WGS sequence.
DR GO; GO:0000932; C:P-body; IEA:UniProtKB-SubCell.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0031047; P:regulatory ncRNA-mediated gene silencing; IEA:UniProtKB-KW.
DR CDD; cd19756; Bbox2; 1.
DR CDD; cd14961; NHL_TRIM32_like; 1.
DR CDD; cd16579; RING-HC_PML_C-V; 1.
DR Gene3D; 2.40.10.500; -; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR017868; Filamin/ABP280_repeat-like.
DR InterPro; IPR001298; Filamin/ABP280_rpt.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR001258; NHL_repeat.
DR InterPro; IPR047153; TRIM45/56/19.
DR InterPro; IPR027370; Znf-RING_euk.
DR InterPro; IPR000315; Znf_B-box.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR25462:SF285; B BOX-TYPE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR25462; BONUS, ISOFORM C-RELATED; 1.
DR Pfam; PF00630; Filamin; 1.
DR Pfam; PF01436; NHL; 2.
DR Pfam; PF00643; zf-B_box; 1.
DR Pfam; PF13445; zf-RING_UBOX; 1.
DR SMART; SM00557; IG_FLMN; 1.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF57845; B-box zinc-binding domain; 1.
DR SUPFAM; SSF81296; E set domains; 1.
DR SUPFAM; SSF101898; NHL repeat; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50194; FILAMIN_REPEAT; 1.
DR PROSITE; PS51125; NHL; 3.
DR PROSITE; PS50119; ZF_BBOX; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000030746};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00024}.
FT DOMAIN 24..72
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT DOMAIN 109..149
FT /note="B box-type"
FT /evidence="ECO:0000259|PROSITE:PS50119"
FT REPEAT 336..408
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 417..458
FT /note="NHL"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00504"
FT REPEAT 513..544
FT /note="NHL"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00504"
FT REPEAT 548..588
FT /note="NHL"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00504"
FT COILED 168..195
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 249..276
FT /evidence="ECO:0000256|SAM:Coils"
FT NON_TER 677
FT /evidence="ECO:0000313|EMBL:ESO91335.1"
SQ SEQUENCE 677 AA; 75075 MW; 79DD773B148BE214 CRC64;
MMSSTLVETV SINYDDFNDS FLTCGTCLCL YDSVEHNPKL LPCSHTVCKH CLERIVAAQN
LDTGSFRCPI CRENIHLPQG GVIAFPPSFL VNQLLDLMAS QRRDVVPKCS VHSNQELLFC
ETCDIVFCSL CSDNNHNGRG ASEHTVIPFA IAIKRMSEIL LYKAHLCIKN LNGAYENISD
ELRSLEQSVD KTLDSINRSF QDVMTIIEKR RHECLQWVRK IREDKRTVLK EQLDLIQAEK
DKVQLDCGNL EYQVEVRNIT KRISDLNEKL DSTSNLAEPR ENAFIKYEFK HNDSLKQIET
AVAKFGQIKI STTFPALCTG KIGEAISHLR SSAQVMTVDY HGNPRLTGSD PVTADLRTDK
GVLVESKVKD NDNGTYDIIF VPPTLGRLKL SVNIFNRAIK NSPFMIEVSD HINPVWKLGS
RGSGIDNLNQ PVRIASGPNG LIFVLDTGNS RIKIINSDGQ VEKHIGPIGL ENQSATGLCL
MNEGNLAVIN WRSKQVSIIT PEGELVRQFT TTEFVEPTDI AVNSRGEIIV ADSGASKIFI
FGSAGNLITT FGSKGIKDGQ FKLISSVTVG KCDEIFVTDH RIQVFSKDGK FSRCLSDSGK
GQYGGIVVDN GGLLLATKTE KGRSFVQVMI MNSNGKLHNI IDSNEEKLKR PSGIAILPNF
HVVVADLGND CVKKYRY
//
