ID V4AD74_LOTGI Unreviewed; 1094 AA.
AC V4AD74;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE RecName: Full=tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=LOTGIDRAFT_230512 {ECO:0000313|EMBL:ESP01939.1};
OS Lottia gigantea (Giant owl limpet).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Patellogastropoda; Lottioidea; Lottiidae; Lottia.
OX NCBI_TaxID=225164 {ECO:0000313|EMBL:ESP01939.1, ECO:0000313|Proteomes:UP000030746};
RN [1] {ECO:0000313|EMBL:ESP01939.1, ECO:0000313|Proteomes:UP000030746}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KB200329; ESP01939.1; -; Genomic_DNA.
DR RefSeq; XP_009047097.1; XM_009048849.1.
DR AlphaFoldDB; V4AD74; -.
DR STRING; 225164.V4AD74; -.
DR EnsemblMetazoa; LotgiT230512; LotgiP230512; LotgiG230512.
DR GeneID; 20248317; -.
DR KEGG; lgi:LOTGIDRAFT_230512; -.
DR CTD; 20248317; -.
DR HOGENOM; CLU_003433_9_1_1; -.
DR OMA; CATVDPQ; -.
DR OrthoDB; 5471897at2759; -.
DR Proteomes; UP000030746; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000049; F:tRNA binding; IEA:UniProtKB-KW.
DR GO; GO:0006400; P:tRNA modification; IEA:UniProt.
DR CDD; cd01993; Alpha_ANH_like_II; 1.
DR Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR Gene3D; 3.40.50.620; HUPs; 1.
DR Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR InterPro; IPR000192; Aminotrans_V_dom.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR InterPro; IPR011063; TilS/TtcA_N.
DR PANTHER; PTHR43686; SULFURTRANSFERASE-RELATED; 1.
DR PANTHER; PTHR43686:SF1; TRNA-CYTIDINE(32) 2-SULFURTRANSFERASE; 1.
DR Pfam; PF00266; Aminotran_5; 2.
DR Pfam; PF01171; ATP_bind_3; 1.
DR SUPFAM; SSF52402; Adenine nucleotide alpha hydrolases-like; 1.
DR SUPFAM; SSF53383; PLP-dependent transferases; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000030746};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884};
KW tRNA-binding {ECO:0000256|ARBA:ARBA00022555}.
FT DOMAIN 72..258
FT /note="Aminotransferase class V"
FT /evidence="ECO:0000259|Pfam:PF00266"
FT DOMAIN 288..449
FT /note="Aminotransferase class V"
FT /evidence="ECO:0000259|Pfam:PF00266"
FT DOMAIN 857..1027
FT /note="tRNA(Ile)-lysidine/2-thiocytidine synthase N-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF01171"
FT REGION 761..798
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 761..785
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1094 AA; 123913 MW; ABDEE25A83269660 CRC64;
MLFAIEEFFK EVKKMSESNE NRLFYTIPKH ELVEKNDESL TTKEKLLSYI RDNIIGSEKI
FGGPFGLRNV LYLDYIASGR SLKFIEDYIQ AEVLPEYGNT HTTTSVTALQ TTLYRHEARD
IIRNACNASE HDSVIFVGSG CTGAVHKLIC ALNLKHPPIV LVSPFEHHST FLPWLEGGAQ
VIRIKESLNG DVDLDHLKHM LQKYKESGRQ LIGCFSAVSN ITGIIVDINT ITISLHKYGA
LAFWDYATAA PYLQIDMNPV INRLIGFYLQ IDVNNVIKSE DQAYVYKDAI FISVHKFIGG
VSTPGVLLAK KNLFNNKRPD VCGGGTVFFV RREGHRYLQE PELKEEGGTP AIVESIRAGM
VFQLKQALTP SFIMEKEHLL YKKAISMWSQ CPNLVILGNP SAPRLPVFSF LIYNPLNGRF
LHHNFVSSIL NDVFGIQSRG GCACAGPYAM DLLGLSEEKA KQIEELLVED KRLDRTHLRR
YKEYSHREII RPGFTRLNLP YFLTEVQLDF TIKAVTMVAE HGWKLLPQYI FNPETGEWKQ
KNFQNFKDRK WLGHILYQNG QMEFKIPAAT VKGPLPTNFQ ECLKMAEVIF DKATKLKTTL
PDQSLLFDED TKPFRWFMLP SEAQDCLHGN HTPALTLTDL PFCPNVLKQR HGFPTEILHT
EILLNSKPLI PRENDELGNK EAFCDGMIQC LNLGYEEMDE NSQEKCNSNV YPSVKNCELT
SNTVAEDNGS ETVTPVFYSE AKSDNFTARL SSKDLNSAEE TLEKFDSDNS KHEISQKDRT
IGMQSDTSKE TELSSSKTNE SKAVGVVCPL LRKADNKISE EAEVKTKQVQ WFSPPRDIFK
PSVTAIEEYN MIHNGDKLLV CLSGGKDSLS LLHTIRQYQF YAKAKGIHFE FGAVTVDPQT
PAYDPSPLKD YLASLGVPYF FESQGILETA SNLPYECASI CSFCSRMKRG RIYACARREG
YNVLALGQHL DDLSESFLMS FFHNGSLRTM KACYTVKQGD LRVIRPFVYV REKLLRTFAE
KSKLPVIAEN CPACFEAPKE RHRSKQLLAS QELLFPQLYN SMMAAMKPLM AINTTKSSLS
NIFNQNNSTE ETDD
//
