ID V4AGF6_LOTGI Unreviewed; 1195 AA.
AC V4AGF6;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE RecName: Full=Calcium-activated potassium channel BK alpha subunit domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=LOTGIDRAFT_232492 {ECO:0000313|EMBL:ESO94250.1};
OS Lottia gigantea (Giant owl limpet).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Patellogastropoda; Lottioidea; Lottiidae; Lottia.
OX NCBI_TaxID=225164 {ECO:0000313|EMBL:ESO94250.1, ECO:0000313|Proteomes:UP000030746};
RN [1] {ECO:0000313|EMBL:ESO94250.1, ECO:0000313|Proteomes:UP000030746}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; KB201847; ESO94250.1; -; Genomic_DNA.
DR RefSeq; XP_009055095.1; XM_009056847.1.
DR AlphaFoldDB; V4AGF6; -.
DR EnsemblMetazoa; LotgiT232492; LotgiP232492; LotgiG232492.
DR GeneID; 20248940; -.
DR KEGG; lgi:LOTGIDRAFT_232492; -.
DR CTD; 20248940; -.
DR HOGENOM; CLU_003370_0_0_1; -.
DR OMA; XRERENG; -.
DR OrthoDB; 49040at2759; -.
DR Proteomes; UP000030746; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0006813; P:potassium ion transport; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR InterPro; IPR003929; K_chnl_BK_asu.
DR InterPro; IPR013099; K_chnl_dom.
DR InterPro; IPR047871; K_chnl_Slo-like.
DR PANTHER; PTHR10027; CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA CHAIN; 1.
DR PANTHER; PTHR10027:SF10; SLOWPOKE 2, ISOFORM D; 1.
DR Pfam; PF03493; BK_channel_a; 1.
DR Pfam; PF07885; Ion_trans_2; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
PE 4: Predicted;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Potassium {ECO:0000256|ARBA:ARBA00022958};
KW Potassium channel {ECO:0000256|ARBA:ARBA00022826};
KW Potassium transport {ECO:0000256|ARBA:ARBA00022538};
KW Reference proteome {ECO:0000313|Proteomes:UP000030746};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 113..134
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 146..170
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 215..236
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 242..262
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 269..287
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 221..296
FT /note="Potassium channel"
FT /evidence="ECO:0000259|Pfam:PF07885"
FT DOMAIN 468..562
FT /note="Calcium-activated potassium channel BK alpha
FT subunit"
FT /evidence="ECO:0000259|Pfam:PF03493"
FT REGION 677..700
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1157..1195
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1157..1178
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1195 AA; 135329 MW; CC9FCE30F41A8A38 CRC64;
MVEDLQGWLG QKEEQNLSAP VKHFTHELSI RGRLRRLLIK NPTTRLCSTV FDVCVKCLVC
ILYVTRVCLD DHKQFSCYGE ICPSNINKST PVSEGFSSTN IHWHVLLWVH RPLALWLVQV
ILAVITLVKA SLQVYCHTKG TRLENLLFDG FLMEVACSFP VILTCCYPVL LQNMYLPVFM
NCWLGRGALA RLFNDLHLRK QRFQTISVTL SQQMMLLNIT LLCLVFTTIC GIQHIQRGSD
ETSLTMFESL YFVIVTFSTV GYGDISPDIW LGQLFMFVMI IVAFAFIPRQ LEEIGSTWIQ
QKKSGGEYKK GESPRHRHVV VCMRFPNTEM VMNFLNEFYA HPKLEQHTVV LISPNELEND
MQMILKDPKW ANRVVYIRGS ALKDVDLKRC RINQADACFF LAPKNTGDRN KAMKGGGAGK
KGAHNVLGSE RDQHTILRSW AVKDFAPQCR QYLQLFKAEN KMHVKFAEHV VCEDEFKYAL
LANNCLYPGL STLVTLLLHT SRGREGEVAN EPWQQIYGRH SGMEVYHIQL NKSSFFRKFE
GKKFTEASVV AHQRYGVCLV AVLDVNRSEP RLQLNPGSDH ILKGSDFCFY LGMTREEYSK
INACAETEAV DSARTKNIEL IASEIQKWLQ SEEEGDVDDD ESLFSTITSQ LGKTITHRLQ
HNNDVSTPLL SSPVEKDTIK KPVSSSTAAK GTETLERFSQ QESGKILQFY DMGQESFITG
PPPSTLYVGT KRTSCHLHRD RRPSCCTKWG EVCEHCSFKT AKDERWDQQL IILVAGYGST
GIYNFIVPLR SDYLNVNNLS PIILLLEQEP DKMFIETIAH FPLVYWMQGK MTSIDDLLVA
GINKATHLVV ANKENDSDIQ EDVLSDAETV VTVQKITNLF PATNVITELN DASNMRFMQF
QAHDAYSQSI SKLEKRLKEE TNSNLPHLFR LPFTSGQVFS AGMLDRLLYQ TFVKGYLISF
VRLLLGIDAE PNSGHLSSVR VRRATLAQFP TYNDLYQGLC STTGEIPIAI YRTEKRPALS
VAALEKMDNE EVLVNNNSKH FGLPSRPSIP AKLFAQSDTD FNRPSELVYS RMKSLDLSDD
IHCDTPLDSN ILSYVIVNPS PKRKLKSGDM IYVIQPSSMF AVPNKLKWRS PKMHRKNFVV
SPASTPVLAR TTRISWNLSP DQRKNSANSS STSAVKGEGE GRSRSKSESQ VNQSK
//
