ID V4AGJ6_LOTGI Unreviewed; 823 AA.
AC V4AGJ6;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE RecName: Full=DNA mismatch repair proteins mutS family domain-containing protein {ECO:0000259|PROSITE:PS00486};
GN ORFNames=LOTGIDRAFT_233005 {ECO:0000313|EMBL:ESO92536.1};
OS Lottia gigantea (Giant owl limpet).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Patellogastropoda; Lottioidea; Lottiidae; Lottia.
OX NCBI_TaxID=225164 {ECO:0000313|EMBL:ESO92536.1, ECO:0000313|Proteomes:UP000030746};
RN [1] {ECO:0000313|EMBL:ESO92536.1, ECO:0000313|Proteomes:UP000030746}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KB202050; ESO92536.1; -; Genomic_DNA.
DR RefSeq; XP_009056678.1; XM_009058430.1.
DR AlphaFoldDB; V4AGJ6; -.
DR STRING; 225164.V4AGJ6; -.
DR EnsemblMetazoa; LotgiT233005; LotgiP233005; LotgiG233005.
DR GeneID; 20249120; -.
DR KEGG; lgi:LOTGIDRAFT_233005; -.
DR CTD; 20249120; -.
DR HOGENOM; CLU_002472_8_0_1; -.
DR OMA; METHQDG; -.
DR OrthoDB; 9867at2759; -.
DR Proteomes; UP000030746; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0007127; P:meiosis I; IEA:UniProt.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR CDD; cd03281; ABC_MSH5_euk; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR011184; DNA_mismatch_repair_Msh2.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR PANTHER; PTHR11361:SF20; MUTS PROTEIN HOMOLOG 5; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF005813; MSH2; 2.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000030746}.
FT DOMAIN 658..674
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT REGION 1..40
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 823 AA; 92860 MW; F40292A20F9B8992 CRC64;
MYNHSSCQSD GSSSSTSIRS NNISRPKSRT PTTTSSNTIE DIIRPDDITS IRNVIEGSTD
SETEQLYLSV VWYGGKLGLA YYDVDTLQIH VMLDTMETDD FSYLKRAIKQ IEPAEIILSS
KQDDRLLKAL KKTVEEVYCG KRTDSNPASD TSSILQYMPS IDFSLEICKR RILSIDLPAM
PKHYTDTERI LYMSSLISFD NVSMVKATGG LLKFLEKKRI GVELESHDVR VPVLGFKNFS
LEDQMILDDS AYNALLIFHK ECHPSVYKSG TAYSGKEGLS LFAVSFFSLP RNIEVLSTLQ
DCMKHIRNIP RILSKMVLAQ ASIADWQVMY KTVYHAIYIG DICRSQAANI AIFKKVATSF
SDDLHRIATL ISKIIDFDES VTQSRFVVKP NVDAELDEKK RTYNGLPDFM TKVAREELNK
LGNNITECSV IYLPHLCYLL AIPKTDAMVN EEDYEIPGLD FKFMSNNMLH YKSPRTRELD
TLLGDTQCEI IDHETNIMHR LQNTILEHSK VLNDVMEYTA ELDCLMSLST CAREFGYIKP
EMVEDNIIDV EGGRHPIQEL CCSPFVPNDY CSNNTDGRIK ILTGPNACGK SVYLKQIALI
VYMAHIGSFV PAEKATIGTV DRIFTRIKSL ESVSVGLSTF MLDITQMSEA LNSAMSRSLI
LVDEFGKGTQ TIDGLSLLCA TLRYWLAMQN ACPHVMVSTH FHSIVHEQLL PKSPQLKFLT
LDTLHNGEDL VFLYQVVNGT TSSSYASHVA SKVGLPEALV KRGIEVSELI RKKQPIQRLD
SESTAVKFKK CRKIVKKFCE LDFEKDDVEQ FLNEVVLPIY NKE
//
