ID V4AI07_LOTGI Unreviewed; 248 AA.
AC V4AI07;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=Fucolectin tachylectin-4 pentraxin-1 domain-containing protein {ECO:0000259|SMART:SM00607};
GN ORFNames=LOTGIDRAFT_159958 {ECO:0000313|EMBL:ESO96542.1};
OS Lottia gigantea (Giant owl limpet).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Patellogastropoda; Lottioidea; Lottiidae; Lottia.
OX NCBI_TaxID=225164 {ECO:0000313|EMBL:ESO96542.1, ECO:0000313|Proteomes:UP000030746};
RN [1] {ECO:0000313|EMBL:ESO96542.1, ECO:0000313|Proteomes:UP000030746}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
CC -!- FUNCTION: Acts as a defensive agent. Recognizes blood group fucosylated
CC oligosaccharides including A, B, H and Lewis B-type antigens. Does not
CC recognize Lewis A antigen and has low affinity for monovalent haptens.
CC {ECO:0000256|ARBA:ARBA00002219}.
CC -!- SUBUNIT: Homotrimer. {ECO:0000256|ARBA:ARBA00011233}.
CC -!- SIMILARITY: Belongs to the fucolectin family.
CC {ECO:0000256|ARBA:ARBA00010147}.
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DR EMBL; KB201459; ESO96542.1; -; Genomic_DNA.
DR RefSeq; XP_009052895.1; XM_009054647.1.
DR AlphaFoldDB; V4AI07; -.
DR EnsemblMetazoa; LotgiT159958; LotgiP159958; LotgiG159958.
DR GeneID; 20238229; -.
DR KEGG; lgi:LOTGIDRAFT_159958; -.
DR CTD; 20238229; -.
DR HOGENOM; CLU_096944_0_0_1; -.
DR OrthoDB; 2971490at2759; -.
DR Proteomes; UP000030746; Unassembled WGS sequence.
DR GO; GO:0042806; F:fucose binding; IEA:UniProt.
DR GO; GO:0010185; P:regulation of cellular defense response; IEA:UniProt.
DR GO; GO:0001868; P:regulation of complement activation, lectin pathway; IEA:UniProt.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR InterPro; IPR000421; FA58C.
DR InterPro; IPR006585; FTP1.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR PANTHER; PTHR45713:SF6; F5_8 TYPE C DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR45713; FTP DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00754; F5_F8_type_C; 1.
DR SMART; SM00607; FTP; 1.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
PE 3: Inferred from homology;
KW Lectin {ECO:0000256|ARBA:ARBA00022734};
KW Reference proteome {ECO:0000313|Proteomes:UP000030746}.
FT DOMAIN 20..174
FT /note="Fucolectin tachylectin-4 pentraxin-1"
FT /evidence="ECO:0000259|SMART:SM00607"
SQ SEQUENCE 248 AA; 27799 MW; 5B1ECCEFC0FE471C CRC64;
MRVVTYYKLW LNTDMPEGRR RNLALNKPAT QISQYLGFEA GKANDGIDGI SVDTGGCSHT
AGYAALVPET HPWWEVDLSQ EYYISAVAIS HPVYDLPQLA HNFSIEIYTD GETINDAVLC
YYHPGLATTN STELYWCKTT IKGRHVRITI NGNRAEMLLL CEVKVIGSEY LTTTSFIKFD
NADLESPDMT YSVQGYGQCA MKCYVLPMCH IFSVKSVSDY YLCNIFTNMY PKLVGNSTGR
PGIVAFIM
//
